Smart‐Responsive Multifunctional Therapeutic System for Improved Regenerative Microenvironment and Accelerated Bone Regeneration via Mild Photothermal Therapy
Abstract The treatment of bone defects remains a substantial clinical challenge due to the lack of spatiotemporal management of the immune microenvironment, revascularization, and osteogenic differentiation. Herein, deferoxamine (DFO)‐loaded black phosphorus nanosheets decorated by polydopamine laye...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202304641 |
| _version_ | 1797356413787308032 |
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| author | Minhao Wu Huifan Liu Dan Li Yufan Zhu Ping Wu Zhe Chen Feixiang Chen Yun Chen Zhouming Deng Lin Cai |
| author_facet | Minhao Wu Huifan Liu Dan Li Yufan Zhu Ping Wu Zhe Chen Feixiang Chen Yun Chen Zhouming Deng Lin Cai |
| author_sort | Minhao Wu |
| collection | DOAJ |
| description | Abstract The treatment of bone defects remains a substantial clinical challenge due to the lack of spatiotemporal management of the immune microenvironment, revascularization, and osteogenic differentiation. Herein, deferoxamine (DFO)‐loaded black phosphorus nanosheets decorated by polydopamine layer are prepared (BPPD) and compounded into gelatin methacrylate/sodium alginate methacrylate (GA) hybrid hydrogel as a smart‐responsive therapeutic system (GA/BPPD) for accelerated bone regeneration. The BPPD nanocomposites served as bioactive components and near‐infrared (NIR) photothermal agents, which conferred the hydrogel with excellent NIR/pH dual‐responsive properties, realizing the stimuli‐responsive release of DFO and PO43 − during bone regeneration. Under the action of NIR‐triggered mild photothermal therapy, the GA/BPPD hydrogel exhibited a positive effect on promoting osteogenesis and angiogenesis, eliminating excessive reactive oxygen species, and inducing macrophage polarization to the M2 phenotype. More significantly, through macrophage M2 polarization‐induced osteoimmune microenvironment, this hydrogel platform could also drive functional cytokine secretion for enhanced angiogenesis and osteogenesis. In vivo experiments further demonstrated that the GA/BPPD system could facilitate bone healing by attenuating the local inflammatory response, increasing the secretion of pro‐healing factors, stimulating endogenous cell recruitment, and accelerating revascularization. Collectively, the proposed intelligent photothermal hydrogel platform provides a promising strategy to reshape the damaged tissue microenvironment for augmented bone regeneration. |
| first_indexed | 2024-03-08T14:26:18Z |
| format | Article |
| id | doaj.art-8d10027356bf47f9a9b7b9dc9b6902d7 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-08T14:26:18Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-8d10027356bf47f9a9b7b9dc9b6902d72024-01-13T04:23:06ZengWileyAdvanced Science2198-38442024-01-01112n/an/a10.1002/advs.202304641Smart‐Responsive Multifunctional Therapeutic System for Improved Regenerative Microenvironment and Accelerated Bone Regeneration via Mild Photothermal TherapyMinhao Wu0Huifan Liu1Dan Li2Yufan Zhu3Ping Wu4Zhe Chen5Feixiang Chen6Yun Chen7Zhouming Deng8Lin Cai9Department of Spine Surgery and Musculoskeletal Tumor Zhongnan Hospital of Wuhan University 168 Donghu Street, Wuchang District Wuhan Hubei 430071 P. R. ChinaDepartment of Anesthesiology Research Centre of Anesthesiology and Critical Care Medicine Zhongnan Hospital of Wuhan University Wuhan Hubei P. R. ChinaDepartment of Neonatology, Xianning Central hospital School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology Xianning Hubei 437100 P. R. ChinaDepartment of Spine Surgery and Musculoskeletal Tumor Zhongnan Hospital of Wuhan University 168 Donghu Street, Wuchang District Wuhan Hubei 430071 P. R. ChinaResearch Units of Clinical Translation of Cell Growth Factors and Diseases Research Chinese Academy of Medical Science Zhejiang 325000 P. R. ChinaDepartment of Spine Surgery and Musculoskeletal Tumor Zhongnan Hospital of Wuhan University 168 Donghu Street, Wuchang District Wuhan Hubei 430071 P. R. ChinaDepartment of Biomedical Engineering and Hubei Province Key Laboratory of Allergy and Immune Related Disease TaiKang Medical School (School of Basic Medicine Sciences) Wuhan University Wuhan 430071 P. R. ChinaDepartment of Biomedical Engineering and Hubei Province Key Laboratory of Allergy and Immune Related Disease TaiKang Medical School (School of Basic Medicine Sciences) Wuhan University Wuhan 430071 P. R. ChinaDepartment of Spine Surgery and Musculoskeletal Tumor Zhongnan Hospital of Wuhan University 168 Donghu Street, Wuchang District Wuhan Hubei 430071 P. R. ChinaDepartment of Spine Surgery and Musculoskeletal Tumor Zhongnan Hospital of Wuhan University 168 Donghu Street, Wuchang District Wuhan Hubei 430071 P. R. ChinaAbstract The treatment of bone defects remains a substantial clinical challenge due to the lack of spatiotemporal management of the immune microenvironment, revascularization, and osteogenic differentiation. Herein, deferoxamine (DFO)‐loaded black phosphorus nanosheets decorated by polydopamine layer are prepared (BPPD) and compounded into gelatin methacrylate/sodium alginate methacrylate (GA) hybrid hydrogel as a smart‐responsive therapeutic system (GA/BPPD) for accelerated bone regeneration. The BPPD nanocomposites served as bioactive components and near‐infrared (NIR) photothermal agents, which conferred the hydrogel with excellent NIR/pH dual‐responsive properties, realizing the stimuli‐responsive release of DFO and PO43 − during bone regeneration. Under the action of NIR‐triggered mild photothermal therapy, the GA/BPPD hydrogel exhibited a positive effect on promoting osteogenesis and angiogenesis, eliminating excessive reactive oxygen species, and inducing macrophage polarization to the M2 phenotype. More significantly, through macrophage M2 polarization‐induced osteoimmune microenvironment, this hydrogel platform could also drive functional cytokine secretion for enhanced angiogenesis and osteogenesis. In vivo experiments further demonstrated that the GA/BPPD system could facilitate bone healing by attenuating the local inflammatory response, increasing the secretion of pro‐healing factors, stimulating endogenous cell recruitment, and accelerating revascularization. Collectively, the proposed intelligent photothermal hydrogel platform provides a promising strategy to reshape the damaged tissue microenvironment for augmented bone regeneration.https://doi.org/10.1002/advs.202304641angiogenesisbone regenerationimmune microenvironmentmild photothermal activityon‐demand deliverysmart release hydrogel |
| spellingShingle | Minhao Wu Huifan Liu Dan Li Yufan Zhu Ping Wu Zhe Chen Feixiang Chen Yun Chen Zhouming Deng Lin Cai Smart‐Responsive Multifunctional Therapeutic System for Improved Regenerative Microenvironment and Accelerated Bone Regeneration via Mild Photothermal Therapy Advanced Science angiogenesis bone regeneration immune microenvironment mild photothermal activity on‐demand delivery smart release hydrogel |
| title | Smart‐Responsive Multifunctional Therapeutic System for Improved Regenerative Microenvironment and Accelerated Bone Regeneration via Mild Photothermal Therapy |
| title_full | Smart‐Responsive Multifunctional Therapeutic System for Improved Regenerative Microenvironment and Accelerated Bone Regeneration via Mild Photothermal Therapy |
| title_fullStr | Smart‐Responsive Multifunctional Therapeutic System for Improved Regenerative Microenvironment and Accelerated Bone Regeneration via Mild Photothermal Therapy |
| title_full_unstemmed | Smart‐Responsive Multifunctional Therapeutic System for Improved Regenerative Microenvironment and Accelerated Bone Regeneration via Mild Photothermal Therapy |
| title_short | Smart‐Responsive Multifunctional Therapeutic System for Improved Regenerative Microenvironment and Accelerated Bone Regeneration via Mild Photothermal Therapy |
| title_sort | smart responsive multifunctional therapeutic system for improved regenerative microenvironment and accelerated bone regeneration via mild photothermal therapy |
| topic | angiogenesis bone regeneration immune microenvironment mild photothermal activity on‐demand delivery smart release hydrogel |
| url | https://doi.org/10.1002/advs.202304641 |
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