Long noncoding RNA: a dazzling dancer in tumor immune microenvironment
Abstract Long noncoding RNAs (lncRNAs) are a class of endogenous, non-protein coding RNAs that are highly linked to various cellular functions and pathological process. Emerging evidence indicates that lncRNAs participate in crosstalk between tumor and stroma, and reprogramming of tumor immune micro...
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| Format: | Article |
| Language: | English |
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BMC
2020-11-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13046-020-01727-3 |
| _version_ | 1818187962010042368 |
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| author | Yalu Zhang Qiaofei Liu Quan Liao |
| author_facet | Yalu Zhang Qiaofei Liu Quan Liao |
| author_sort | Yalu Zhang |
| collection | DOAJ |
| description | Abstract Long noncoding RNAs (lncRNAs) are a class of endogenous, non-protein coding RNAs that are highly linked to various cellular functions and pathological process. Emerging evidence indicates that lncRNAs participate in crosstalk between tumor and stroma, and reprogramming of tumor immune microenvironment (TIME). TIME possesses distinct populations of myeloid cells and lymphocytes to influence the immune escape of cancer, the response to immunotherapy, and the survival of patients. However, hitherto, a comprehensive review aiming at relationship between lncRNAs and TIME is missing. In this review, we focus on the functional roles and molecular mechanisms of lncRNAs within the TIME. Furthermore, we discussed the potential immunotherapeutic strategies based on lncRNAs and their limitations. |
| first_indexed | 2024-12-11T23:19:21Z |
| format | Article |
| id | doaj.art-8d138e6486aa4bac9fa1d23c2bf5f69f |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-12-11T23:19:21Z |
| publishDate | 2020-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-8d138e6486aa4bac9fa1d23c2bf5f69f2022-12-22T00:46:23ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662020-11-0139112510.1186/s13046-020-01727-3Long noncoding RNA: a dazzling dancer in tumor immune microenvironmentYalu Zhang0Qiaofei Liu1Quan Liao2Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeAbstract Long noncoding RNAs (lncRNAs) are a class of endogenous, non-protein coding RNAs that are highly linked to various cellular functions and pathological process. Emerging evidence indicates that lncRNAs participate in crosstalk between tumor and stroma, and reprogramming of tumor immune microenvironment (TIME). TIME possesses distinct populations of myeloid cells and lymphocytes to influence the immune escape of cancer, the response to immunotherapy, and the survival of patients. However, hitherto, a comprehensive review aiming at relationship between lncRNAs and TIME is missing. In this review, we focus on the functional roles and molecular mechanisms of lncRNAs within the TIME. Furthermore, we discussed the potential immunotherapeutic strategies based on lncRNAs and their limitations.http://link.springer.com/article/10.1186/s13046-020-01727-3LncRNATumor immune microenvironmentCancer immunotherapy |
| spellingShingle | Yalu Zhang Qiaofei Liu Quan Liao Long noncoding RNA: a dazzling dancer in tumor immune microenvironment Journal of Experimental & Clinical Cancer Research LncRNA Tumor immune microenvironment Cancer immunotherapy |
| title | Long noncoding RNA: a dazzling dancer in tumor immune microenvironment |
| title_full | Long noncoding RNA: a dazzling dancer in tumor immune microenvironment |
| title_fullStr | Long noncoding RNA: a dazzling dancer in tumor immune microenvironment |
| title_full_unstemmed | Long noncoding RNA: a dazzling dancer in tumor immune microenvironment |
| title_short | Long noncoding RNA: a dazzling dancer in tumor immune microenvironment |
| title_sort | long noncoding rna a dazzling dancer in tumor immune microenvironment |
| topic | LncRNA Tumor immune microenvironment Cancer immunotherapy |
| url | http://link.springer.com/article/10.1186/s13046-020-01727-3 |
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