Plexin B3 guides axons to cross the midline in vivo
During the development of neural circuits, axons are guided by a variety of molecular cues to navigate through the brain and establish precise connections with correct partners at the right time and place. Many axon guidance cues have been identified and they play pleiotropic roles in not only axon...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2024.1292969/full |
| _version_ | 1797230539047960576 |
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| author | Zhi-Zhi Liu Zhi-Zhi Liu Zhi-Zhi Liu Zhi-Zhi Liu Ling-Yan Liu Ling-Yan Liu Ling-Yan Liu Ling-Yan Liu Lou-Yin Zhu Lou-Yin Zhu Jian Zhu Jian Zhu Jia-Yu Luo Jia-Yu Luo Jia-Yu Luo Jia-Yu Luo Ye-Fan Wang Ye-Fan Wang Hong A. Xu Hong A. Xu Hong A. Xu Hong A. Xu |
| author_facet | Zhi-Zhi Liu Zhi-Zhi Liu Zhi-Zhi Liu Zhi-Zhi Liu Ling-Yan Liu Ling-Yan Liu Ling-Yan Liu Ling-Yan Liu Lou-Yin Zhu Lou-Yin Zhu Jian Zhu Jian Zhu Jia-Yu Luo Jia-Yu Luo Jia-Yu Luo Jia-Yu Luo Ye-Fan Wang Ye-Fan Wang Hong A. Xu Hong A. Xu Hong A. Xu Hong A. Xu |
| author_sort | Zhi-Zhi Liu |
| collection | DOAJ |
| description | During the development of neural circuits, axons are guided by a variety of molecular cues to navigate through the brain and establish precise connections with correct partners at the right time and place. Many axon guidance cues have been identified and they play pleiotropic roles in not only axon guidance but also axon fasciculation, axon pruning, and synaptogenesis as well as cell migration, angiogenesis, and bone formation. In search of receptors for Sema3E in axon guidance, we unexpectedly found that Plexin B3 is highly expressed in retinal ganglion cells of zebrafish embryos when retinal axons are crossing the midline to form the chiasm. Plexin B3 has been characterized to be related to neurodevelopmental disorders. However, the investigation of its pathological mechanisms is hampered by the lack of appropriate animal model. We provide evidence that Plexin B3 is critical for axon guidance in vivo. Plexin B3 might function as a receptor for Sema3E while Neuropilin1 could be a co-receptor. The intracellular domain of Plexin B3 is required for Semaphorin signaling transduction. Our data suggest that zebrafish could be an ideal animal model for investigating the role and mechanisms of Sema3E and Plexin B3 in vivo. |
| first_indexed | 2024-04-24T15:30:05Z |
| format | Article |
| id | doaj.art-8d13f5651b5e4d638c32e4eee7590672 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-24T15:30:05Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-8d13f5651b5e4d638c32e4eee75906722024-04-02T04:30:19ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022024-04-011810.3389/fncel.2024.12929691292969Plexin B3 guides axons to cross the midline in vivoZhi-Zhi Liu0Zhi-Zhi Liu1Zhi-Zhi Liu2Zhi-Zhi Liu3Ling-Yan Liu4Ling-Yan Liu5Ling-Yan Liu6Ling-Yan Liu7Lou-Yin Zhu8Lou-Yin Zhu9Jian Zhu10Jian Zhu11Jia-Yu Luo12Jia-Yu Luo13Jia-Yu Luo14Jia-Yu Luo15Ye-Fan Wang16Ye-Fan Wang17Hong A. Xu18Hong A. Xu19Hong A. Xu20Hong A. Xu21Institute of Biomedical Innovation, Nanchang University, Nanchang, ChinaSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang, ChinaThe Second Affiliated Hospital of Nanchang University, Nanchang, ChinaJiangxi Provincial Collaborative Innovation Center for Cardiovascular, Digestive and Neuropsychiatric diseases, Nanchang, ChinaInstitute of Biomedical Innovation, Nanchang University, Nanchang, ChinaSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang, ChinaThe Second Affiliated Hospital of Nanchang University, Nanchang, ChinaJiangxi Provincial Collaborative Innovation Center for Cardiovascular, Digestive and Neuropsychiatric diseases, Nanchang, ChinaInstitute of Biomedical Innovation, Nanchang University, Nanchang, ChinaSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang, ChinaInstitute of Biomedical Innovation, Nanchang University, Nanchang, ChinaSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang, ChinaInstitute of Biomedical Innovation, Nanchang University, Nanchang, ChinaSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang, ChinaThe Second Affiliated Hospital of Nanchang University, Nanchang, ChinaJiangxi Provincial Collaborative Innovation Center for Cardiovascular, Digestive and Neuropsychiatric diseases, Nanchang, ChinaInstitute of Biomedical Innovation, Nanchang University, Nanchang, ChinaSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang, ChinaInstitute of Biomedical Innovation, Nanchang University, Nanchang, ChinaSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang, ChinaThe Second Affiliated Hospital of Nanchang University, Nanchang, ChinaJiangxi Provincial Collaborative Innovation Center for Cardiovascular, Digestive and Neuropsychiatric diseases, Nanchang, ChinaDuring the development of neural circuits, axons are guided by a variety of molecular cues to navigate through the brain and establish precise connections with correct partners at the right time and place. Many axon guidance cues have been identified and they play pleiotropic roles in not only axon guidance but also axon fasciculation, axon pruning, and synaptogenesis as well as cell migration, angiogenesis, and bone formation. In search of receptors for Sema3E in axon guidance, we unexpectedly found that Plexin B3 is highly expressed in retinal ganglion cells of zebrafish embryos when retinal axons are crossing the midline to form the chiasm. Plexin B3 has been characterized to be related to neurodevelopmental disorders. However, the investigation of its pathological mechanisms is hampered by the lack of appropriate animal model. We provide evidence that Plexin B3 is critical for axon guidance in vivo. Plexin B3 might function as a receptor for Sema3E while Neuropilin1 could be a co-receptor. The intracellular domain of Plexin B3 is required for Semaphorin signaling transduction. Our data suggest that zebrafish could be an ideal animal model for investigating the role and mechanisms of Sema3E and Plexin B3 in vivo.https://www.frontiersin.org/articles/10.3389/fncel.2024.1292969/fullaxon guidanceSemaphorin-Plexin signalingPlexin B3Sema3ENeuropilin1retinal ganglion cells |
| spellingShingle | Zhi-Zhi Liu Zhi-Zhi Liu Zhi-Zhi Liu Zhi-Zhi Liu Ling-Yan Liu Ling-Yan Liu Ling-Yan Liu Ling-Yan Liu Lou-Yin Zhu Lou-Yin Zhu Jian Zhu Jian Zhu Jia-Yu Luo Jia-Yu Luo Jia-Yu Luo Jia-Yu Luo Ye-Fan Wang Ye-Fan Wang Hong A. Xu Hong A. Xu Hong A. Xu Hong A. Xu Plexin B3 guides axons to cross the midline in vivo Frontiers in Cellular Neuroscience axon guidance Semaphorin-Plexin signaling Plexin B3 Sema3E Neuropilin1 retinal ganglion cells |
| title | Plexin B3 guides axons to cross the midline in vivo |
| title_full | Plexin B3 guides axons to cross the midline in vivo |
| title_fullStr | Plexin B3 guides axons to cross the midline in vivo |
| title_full_unstemmed | Plexin B3 guides axons to cross the midline in vivo |
| title_short | Plexin B3 guides axons to cross the midline in vivo |
| title_sort | plexin b3 guides axons to cross the midline in vivo |
| topic | axon guidance Semaphorin-Plexin signaling Plexin B3 Sema3E Neuropilin1 retinal ganglion cells |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2024.1292969/full |
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