Burden of respiratory syncytial virus infections in China: Systematic review and meta–analysis
Respiratory syncytial virus (RSV) is the most important cause of acute respiratory tract infection (ARTI) related morbidity and mortality worldwide. However, the disease burden due to RSV has not been systematically summarized in China. A systematic search was performed in the Chinese BioMedical...
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| Format: | Article |
| Language: | English |
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Edinburgh University Global Health Society
2015-12-01
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| Series: | Journal of Global Health |
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| Online Access: | http://jogh.org/pdfviewer.aspx?pdf=documents/issue201502/jogh-05-020417.pdf |
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| author | Yaowen Zhang Lichao Yuan Yongming Zhang Xiuping Zhang Minghuan Zheng Moe H Kyaw |
| author_facet | Yaowen Zhang Lichao Yuan Yongming Zhang Xiuping Zhang Minghuan Zheng Moe H Kyaw |
| author_sort | Yaowen Zhang |
| collection | DOAJ |
| description | Respiratory syncytial virus (RSV) is the most important cause of acute respiratory tract infection (ARTI) related morbidity and mortality worldwide. However, the disease burden due to RSV has not been systematically summarized in China.
A systematic search was performed in the Chinese BioMedical Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang database and PubMed to identify available published RSV studies in China.
A total of 489 641 patients with ARTIs from 135 studies were included in the analysis. Among patients with ARTIs, RSV accounted for 18.7% (95% confidence interval CI 17.1–20.5%). The prevalence of RSV was highest in infants (26.5%, 95% CI 23.7–29.5%) and lowest in those aged 16 years (2.8%, 95% CI 1.3–6.1). A higher prevalence of RSV was seen in inpatients (22%, 95% CI 19.9–24.2%) than in outpatients (14%, 95% CI 9.6–19.9%). RSV type A accounted for 63.1% (95% CI 52.3–72.8%) of all RSV infections. RSV infections occurred mainly in winter and spring. The most common clinical manifestations were cough, production of sputum, wheezing and fever.
RSV is the leading cause of viral ARTIs in China, particularly in infants and young children. Our findings are valuable for guiding the selection of appropriate therapies for ARTIs and implementation of preventive measures against RSV infections. Our data further supports the development of a successful RSV vaccine as a high priority. |
| first_indexed | 2024-12-16T23:09:23Z |
| format | Article |
| id | doaj.art-8d152f832d0c41ed852a155ebb4d2aeb |
| institution | Directory Open Access Journal |
| issn | 2047-2978 2047-2986 |
| language | English |
| last_indexed | 2024-12-16T23:09:23Z |
| publishDate | 2015-12-01 |
| publisher | Edinburgh University Global Health Society |
| record_format | Article |
| series | Journal of Global Health |
| spelling | doaj.art-8d152f832d0c41ed852a155ebb4d2aeb2022-12-21T22:12:28ZengEdinburgh University Global Health SocietyJournal of Global Health2047-29782047-29862015-12-015210.7189/jogh.05.020421Burden of respiratory syncytial virus infections in China: Systematic review and meta–analysisYaowen Zhang0Lichao Yuan1Yongming Zhang2Xiuping Zhang3Minghuan Zheng4Moe H Kyaw5Infection Management and Disease Prevention Department, China–Japan Friendship Hospital, Beijing, ChinaDepartment of Infectious Diseases, China–Japan Friendship Hospital, Beijing, ChinaDepartment of Respiratory Diseases, China–Japan Friendship Hospital, Beijing, ChinaChina–Japan Friendship Clinical College, Beijing University of Chinese Medicine, Beijing, ChinaSanofi Pasteur, Beijing, ChinaSanofi Pasteur, Swiftwater, PA, USARespiratory syncytial virus (RSV) is the most important cause of acute respiratory tract infection (ARTI) related morbidity and mortality worldwide. However, the disease burden due to RSV has not been systematically summarized in China. A systematic search was performed in the Chinese BioMedical Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang database and PubMed to identify available published RSV studies in China. A total of 489 641 patients with ARTIs from 135 studies were included in the analysis. Among patients with ARTIs, RSV accounted for 18.7% (95% confidence interval CI 17.1–20.5%). The prevalence of RSV was highest in infants (26.5%, 95% CI 23.7–29.5%) and lowest in those aged 16 years (2.8%, 95% CI 1.3–6.1). A higher prevalence of RSV was seen in inpatients (22%, 95% CI 19.9–24.2%) than in outpatients (14%, 95% CI 9.6–19.9%). RSV type A accounted for 63.1% (95% CI 52.3–72.8%) of all RSV infections. RSV infections occurred mainly in winter and spring. The most common clinical manifestations were cough, production of sputum, wheezing and fever. RSV is the leading cause of viral ARTIs in China, particularly in infants and young children. Our findings are valuable for guiding the selection of appropriate therapies for ARTIs and implementation of preventive measures against RSV infections. Our data further supports the development of a successful RSV vaccine as a high priority.http://jogh.org/pdfviewer.aspx?pdf=documents/issue201502/jogh-05-020417.pdfRSVburdenChina |
| spellingShingle | Yaowen Zhang Lichao Yuan Yongming Zhang Xiuping Zhang Minghuan Zheng Moe H Kyaw Burden of respiratory syncytial virus infections in China: Systematic review and meta–analysis Journal of Global Health RSV burden China |
| title | Burden of respiratory syncytial virus infections in China: Systematic review and meta–analysis |
| title_full | Burden of respiratory syncytial virus infections in China: Systematic review and meta–analysis |
| title_fullStr | Burden of respiratory syncytial virus infections in China: Systematic review and meta–analysis |
| title_full_unstemmed | Burden of respiratory syncytial virus infections in China: Systematic review and meta–analysis |
| title_short | Burden of respiratory syncytial virus infections in China: Systematic review and meta–analysis |
| title_sort | burden of respiratory syncytial virus infections in china systematic review and meta analysis |
| topic | RSV burden China |
| url | http://jogh.org/pdfviewer.aspx?pdf=documents/issue201502/jogh-05-020417.pdf |
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