Differential Disrupting Effects of Prolonged Low-Dose Exposure to Dichlorodiphenyltrichloroethane on Androgen and Estrogen Production in Males
Dichlorodiphenyltrichloroethane (DDT) is the most widespread, persistent pollutant and endocrine disruptor on the planet. Although DDT has been found to block androgen receptors, the effects of its low-dose exposure in different periods of ontogeny on the male reproductive system remain unclear. We...
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2021-03-01
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| Series: | International Journal of Molecular Sciences |
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| author | Nataliya V. Yaglova Dibakhan A. Tsomartova Sergey S. Obernikhin Valentin V. Yaglov Svetlana V. Nazimova Elina S. Tsomartova Elizaveta V. Chereshneva Marina Y. Ivanova Tatiana A. Lomanovskaya |
| author_facet | Nataliya V. Yaglova Dibakhan A. Tsomartova Sergey S. Obernikhin Valentin V. Yaglov Svetlana V. Nazimova Elina S. Tsomartova Elizaveta V. Chereshneva Marina Y. Ivanova Tatiana A. Lomanovskaya |
| author_sort | Nataliya V. Yaglova |
| collection | DOAJ |
| description | Dichlorodiphenyltrichloroethane (DDT) is the most widespread, persistent pollutant and endocrine disruptor on the planet. Although DDT has been found to block androgen receptors, the effects of its low-dose exposure in different periods of ontogeny on the male reproductive system remain unclear. We evaluate sex steroid hormone production in the pubertal period and after maturation in male Wistar rats exposed to low doses of o,p’-DDT, either during prenatal and postnatal development or postnatal development alone. Prenatally and postnatally exposed rats exhibit lower testosterone production and increased estradiol and estriol serum levels after maturation, associated with the delayed growth of gonads. Postnatally exposed rats demonstrate accelerated growth of gonads and higher testosterone production in the pubertal period. In contrast to the previous group, they do not present raised estradiol production. All of the exposed animals exhibit a reduced conversion of progesterone to 17OH-progesterone after sexual maturation, which indicates putative attenuation of sex steroid production. Thus, the study reveals age-dependent outcomes of low-dose exposure to DDT. Prenatal onset of exposure results in the later onset of androgen production and the enhanced conversion of androgens to estrogens after puberty, while postnatal exposure induces the earlier onset of androgen secretion. |
| first_indexed | 2024-03-10T13:04:59Z |
| format | Article |
| id | doaj.art-8d1540d0f4034327941baaadd76a3811 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:04:59Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8d1540d0f4034327941baaadd76a38112023-11-21T11:13:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01226315510.3390/ijms22063155Differential Disrupting Effects of Prolonged Low-Dose Exposure to Dichlorodiphenyltrichloroethane on Androgen and Estrogen Production in MalesNataliya V. Yaglova0Dibakhan A. Tsomartova1Sergey S. Obernikhin2Valentin V. Yaglov3Svetlana V. Nazimova4Elina S. Tsomartova5Elizaveta V. Chereshneva6Marina Y. Ivanova7Tatiana A. Lomanovskaya8Laboratory of Endocrine System Development, Federal State Budgetary Scientific Institution “Research Institute of Human Morphology”, 117418 Moscow, RussiaLaboratory of Endocrine System Development, Federal State Budgetary Scientific Institution “Research Institute of Human Morphology”, 117418 Moscow, RussiaLaboratory of Endocrine System Development, Federal State Budgetary Scientific Institution “Research Institute of Human Morphology”, 117418 Moscow, RussiaLaboratory of Endocrine System Development, Federal State Budgetary Scientific Institution “Research Institute of Human Morphology”, 117418 Moscow, RussiaLaboratory of Endocrine System Development, Federal State Budgetary Scientific Institution “Research Institute of Human Morphology”, 117418 Moscow, RussiaLaboratory of Endocrine System Development, Federal State Budgetary Scientific Institution “Research Institute of Human Morphology”, 117418 Moscow, RussiaDepartment of Histology, Cytology, and Embryology, Federal State Funded Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, 119435 Moscow, RussiaDepartment of Histology, Cytology, and Embryology, Federal State Funded Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, 119435 Moscow, RussiaDepartment of Histology, Cytology, and Embryology, Federal State Funded Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, 119435 Moscow, RussiaDichlorodiphenyltrichloroethane (DDT) is the most widespread, persistent pollutant and endocrine disruptor on the planet. Although DDT has been found to block androgen receptors, the effects of its low-dose exposure in different periods of ontogeny on the male reproductive system remain unclear. We evaluate sex steroid hormone production in the pubertal period and after maturation in male Wistar rats exposed to low doses of o,p’-DDT, either during prenatal and postnatal development or postnatal development alone. Prenatally and postnatally exposed rats exhibit lower testosterone production and increased estradiol and estriol serum levels after maturation, associated with the delayed growth of gonads. Postnatally exposed rats demonstrate accelerated growth of gonads and higher testosterone production in the pubertal period. In contrast to the previous group, they do not present raised estradiol production. All of the exposed animals exhibit a reduced conversion of progesterone to 17OH-progesterone after sexual maturation, which indicates putative attenuation of sex steroid production. Thus, the study reveals age-dependent outcomes of low-dose exposure to DDT. Prenatal onset of exposure results in the later onset of androgen production and the enhanced conversion of androgens to estrogens after puberty, while postnatal exposure induces the earlier onset of androgen secretion.https://www.mdpi.com/1422-0067/22/6/3155DDTlow-dose exposureendocrine disruptorandrogenestrogenprogesterone |
| spellingShingle | Nataliya V. Yaglova Dibakhan A. Tsomartova Sergey S. Obernikhin Valentin V. Yaglov Svetlana V. Nazimova Elina S. Tsomartova Elizaveta V. Chereshneva Marina Y. Ivanova Tatiana A. Lomanovskaya Differential Disrupting Effects of Prolonged Low-Dose Exposure to Dichlorodiphenyltrichloroethane on Androgen and Estrogen Production in Males International Journal of Molecular Sciences DDT low-dose exposure endocrine disruptor androgen estrogen progesterone |
| title | Differential Disrupting Effects of Prolonged Low-Dose Exposure to Dichlorodiphenyltrichloroethane on Androgen and Estrogen Production in Males |
| title_full | Differential Disrupting Effects of Prolonged Low-Dose Exposure to Dichlorodiphenyltrichloroethane on Androgen and Estrogen Production in Males |
| title_fullStr | Differential Disrupting Effects of Prolonged Low-Dose Exposure to Dichlorodiphenyltrichloroethane on Androgen and Estrogen Production in Males |
| title_full_unstemmed | Differential Disrupting Effects of Prolonged Low-Dose Exposure to Dichlorodiphenyltrichloroethane on Androgen and Estrogen Production in Males |
| title_short | Differential Disrupting Effects of Prolonged Low-Dose Exposure to Dichlorodiphenyltrichloroethane on Androgen and Estrogen Production in Males |
| title_sort | differential disrupting effects of prolonged low dose exposure to dichlorodiphenyltrichloroethane on androgen and estrogen production in males |
| topic | DDT low-dose exposure endocrine disruptor androgen estrogen progesterone |
| url | https://www.mdpi.com/1422-0067/22/6/3155 |
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