Multidrug-resistant Disseminated Tuberculosis Related to Infliximab in a Patient with Ulcerative Colitis and Negative Evaluation for Latent Tuberculosis
Anti-tumor necrosis factor (anti-TNF) is an effective biological agent for the treatment of moderate-to-severe active ulcerative colitis (UC) refractory to conventional therapy. On the other hand, anti-TNF therapy is strongly associated with a potential risk of tuberculosis (TB). Active TB is a crit...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Jin Publishing & Printing Co.
2019-09-01
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| Series: | The Korean Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.kjg.or.kr/journal/view.html?uid=5496&vmd=Full& |
| _version_ | 1819035340582682624 |
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| author | Yu Kyung Jun Jaeyoung Chun Eun Ae Kang Hyun Jung Lee Jong Pil Im Joo Sung Kim |
| author_facet | Yu Kyung Jun Jaeyoung Chun Eun Ae Kang Hyun Jung Lee Jong Pil Im Joo Sung Kim |
| author_sort | Yu Kyung Jun |
| collection | DOAJ |
| description | Anti-tumor necrosis factor (anti-TNF) is an effective biological agent for the treatment of moderate-to-severe active ulcerative colitis (UC) refractory to conventional therapy. On the other hand, anti-TNF therapy is strongly associated with a potential risk of tuberculosis (TB). Active TB is a critical complication that makes it difficult to treat patients who require anti-TNF for the treatment of UC refractory to conventional therapy. Based on the clinical guidelines, patients with inflammatory bowel disease (IBD) are strongly recommended to screen for latent TB before anti-TNF administration. Considering the possibility of active or reactivated TB related to anti-TNF therapy, all patients with IBD should be monitored closely for TB during anti-TNF therapy, irrespective of the screening results for latent TB. In particular, the risk of anti-TNF-related multidrug-resistant TB (MDR-TB) in patients with IBD has not been elucidated. This paper
reports the first case of disseminated MDR-TB that developed in a UC patient receiving infliximab despite the negative evaluation for latent TB screening. |
| first_indexed | 2024-12-21T07:48:04Z |
| format | Article |
| id | doaj.art-8d184f41ed294ff9892837d693314ddf |
| institution | Directory Open Access Journal |
| issn | 1598-9992 2233-6869 |
| language | English |
| last_indexed | 2024-12-21T07:48:04Z |
| publishDate | 2019-09-01 |
| publisher | Jin Publishing & Printing Co. |
| record_format | Article |
| series | The Korean Journal of Gastroenterology |
| spelling | doaj.art-8d184f41ed294ff9892837d693314ddf2022-12-21T19:11:10ZengJin Publishing & Printing Co.The Korean Journal of Gastroenterology1598-99922233-68692019-09-0174316817410.4166/kjg.2019.74.3.168Multidrug-resistant Disseminated Tuberculosis Related to Infliximab in a Patient with Ulcerative Colitis and Negative Evaluation for Latent TuberculosisYu Kyung Jun0Jaeyoung Chun1Eun Ae Kang2Hyun Jung Lee3Jong Pil Im4Joo Sung Kim5Department of Internal Medicine, Seoul National University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Seoul National University College of Medicine; Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, KoreaAnti-tumor necrosis factor (anti-TNF) is an effective biological agent for the treatment of moderate-to-severe active ulcerative colitis (UC) refractory to conventional therapy. On the other hand, anti-TNF therapy is strongly associated with a potential risk of tuberculosis (TB). Active TB is a critical complication that makes it difficult to treat patients who require anti-TNF for the treatment of UC refractory to conventional therapy. Based on the clinical guidelines, patients with inflammatory bowel disease (IBD) are strongly recommended to screen for latent TB before anti-TNF administration. Considering the possibility of active or reactivated TB related to anti-TNF therapy, all patients with IBD should be monitored closely for TB during anti-TNF therapy, irrespective of the screening results for latent TB. In particular, the risk of anti-TNF-related multidrug-resistant TB (MDR-TB) in patients with IBD has not been elucidated. This paper reports the first case of disseminated MDR-TB that developed in a UC patient receiving infliximab despite the negative evaluation for latent TB screening.http://www.kjg.or.kr/journal/view.html?uid=5496&vmd=Full&Inflammatory bowel diseasesInfliximabTuberculosismultidrug-resistantColitisulcerative |
| spellingShingle | Yu Kyung Jun Jaeyoung Chun Eun Ae Kang Hyun Jung Lee Jong Pil Im Joo Sung Kim Multidrug-resistant Disseminated Tuberculosis Related to Infliximab in a Patient with Ulcerative Colitis and Negative Evaluation for Latent Tuberculosis The Korean Journal of Gastroenterology Inflammatory bowel diseases Infliximab Tuberculosis multidrug-resistant Colitis ulcerative |
| title | Multidrug-resistant Disseminated Tuberculosis Related to Infliximab in a Patient with Ulcerative Colitis and Negative Evaluation for Latent Tuberculosis |
| title_full | Multidrug-resistant Disseminated Tuberculosis Related to Infliximab in a Patient with Ulcerative Colitis and Negative Evaluation for Latent Tuberculosis |
| title_fullStr | Multidrug-resistant Disseminated Tuberculosis Related to Infliximab in a Patient with Ulcerative Colitis and Negative Evaluation for Latent Tuberculosis |
| title_full_unstemmed | Multidrug-resistant Disseminated Tuberculosis Related to Infliximab in a Patient with Ulcerative Colitis and Negative Evaluation for Latent Tuberculosis |
| title_short | Multidrug-resistant Disseminated Tuberculosis Related to Infliximab in a Patient with Ulcerative Colitis and Negative Evaluation for Latent Tuberculosis |
| title_sort | multidrug resistant disseminated tuberculosis related to infliximab in a patient with ulcerative colitis and negative evaluation for latent tuberculosis |
| topic | Inflammatory bowel diseases Infliximab Tuberculosis multidrug-resistant Colitis ulcerative |
| url | http://www.kjg.or.kr/journal/view.html?uid=5496&vmd=Full& |
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