Beyond Conventional: The New Horizon of Anti-Angiogenic microRNAs in Non-Small Cell Lung Cancer Therapy
GLOBOCAN 2018 identified lung cancer as the leading oncological pathology in terms of incidence and mortality rates. Angiogenesis is a key adaptive mechanism of numerous malignancies that promotes metastatic spread in view of the dependency of cancer cells on nutrients and oxygen, favoring invasion....
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-10-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/21/8002 |
| _version_ | 1797549685339062272 |
|---|---|
| author | Alexandru Tirpe Diana Gulei George Razvan Tirpe Andreea Nutu Alexandru Irimie Paola Campomenosi Laura Ancuta Pop Ioana Berindan-Neagoe |
| author_facet | Alexandru Tirpe Diana Gulei George Razvan Tirpe Andreea Nutu Alexandru Irimie Paola Campomenosi Laura Ancuta Pop Ioana Berindan-Neagoe |
| author_sort | Alexandru Tirpe |
| collection | DOAJ |
| description | GLOBOCAN 2018 identified lung cancer as the leading oncological pathology in terms of incidence and mortality rates. Angiogenesis is a key adaptive mechanism of numerous malignancies that promotes metastatic spread in view of the dependency of cancer cells on nutrients and oxygen, favoring invasion. Limitation of the angiogenic process could significantly hamper the disease advancement through starvation of the primary tumor and impairment of metastatic spread. This review explores the basic molecular mechanisms of non-small cell lung cancer (NSCLC) angiogenesis, and discusses the influences of the key proangiogenic factors—the vascular endothelial growth factor-A (VEGF-A), basic fibroblast growth factor (FGF2), several matrix metalloproteinases (MMPs—MMP-2, MMP-7, MMP-9) and hypoxia—and the therapeutic implications of microRNAs (miRNAs, miRs) throughout the entire process, while also providing critical reviews of a number of microRNAs, with a focus on miR-126, miR-182, miR-155, miR-21 and let-7b. Finally, current conventional NSCLC anti-angiogenics—bevacizumab, ramucirumab and nintedanib—are briefly summarized through the lens of evidence-based medicine. |
| first_indexed | 2024-03-10T15:17:58Z |
| format | Article |
| id | doaj.art-8d1b6731315a46d6a49aecad6cea16ce |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:17:58Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8d1b6731315a46d6a49aecad6cea16ce2023-11-20T18:46:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-012121800210.3390/ijms21218002Beyond Conventional: The New Horizon of Anti-Angiogenic microRNAs in Non-Small Cell Lung Cancer TherapyAlexandru Tirpe0Diana Gulei1George Razvan Tirpe2Andreea Nutu3Alexandru Irimie4Paola Campomenosi5Laura Ancuta Pop6Ioana Berindan-Neagoe7Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, RomaniaResearch Center for Advanced Medicine-Medfuture, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Marinescu Street, 400337 Cluj-Napoca, RomaniaCounty Emergency Hospital Cluj-Napoca, 3-5 Clinicilor Street, 400000 Cluj-Napoca, RomaniaResearch Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Marinescu Street, 400337 Cluj-Napoca, Romania11th Department of Oncological Surgery and Gynecological Oncology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400015 Cluj-Napoca, RomaniaDepartment of Biotechnology and Life Sciences, DBSV, University of Insubria, 21100 Varese, ItalyResearch Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Marinescu Street, 400337 Cluj-Napoca, RomaniaResearch Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Marinescu Street, 400337 Cluj-Napoca, RomaniaGLOBOCAN 2018 identified lung cancer as the leading oncological pathology in terms of incidence and mortality rates. Angiogenesis is a key adaptive mechanism of numerous malignancies that promotes metastatic spread in view of the dependency of cancer cells on nutrients and oxygen, favoring invasion. Limitation of the angiogenic process could significantly hamper the disease advancement through starvation of the primary tumor and impairment of metastatic spread. This review explores the basic molecular mechanisms of non-small cell lung cancer (NSCLC) angiogenesis, and discusses the influences of the key proangiogenic factors—the vascular endothelial growth factor-A (VEGF-A), basic fibroblast growth factor (FGF2), several matrix metalloproteinases (MMPs—MMP-2, MMP-7, MMP-9) and hypoxia—and the therapeutic implications of microRNAs (miRNAs, miRs) throughout the entire process, while also providing critical reviews of a number of microRNAs, with a focus on miR-126, miR-182, miR-155, miR-21 and let-7b. Finally, current conventional NSCLC anti-angiogenics—bevacizumab, ramucirumab and nintedanib—are briefly summarized through the lens of evidence-based medicine.https://www.mdpi.com/1422-0067/21/21/8002microRNAmiRNAncRNAlung cancerNSCLCangiogenesis |
| spellingShingle | Alexandru Tirpe Diana Gulei George Razvan Tirpe Andreea Nutu Alexandru Irimie Paola Campomenosi Laura Ancuta Pop Ioana Berindan-Neagoe Beyond Conventional: The New Horizon of Anti-Angiogenic microRNAs in Non-Small Cell Lung Cancer Therapy International Journal of Molecular Sciences microRNA miRNA ncRNA lung cancer NSCLC angiogenesis |
| title | Beyond Conventional: The New Horizon of Anti-Angiogenic microRNAs in Non-Small Cell Lung Cancer Therapy |
| title_full | Beyond Conventional: The New Horizon of Anti-Angiogenic microRNAs in Non-Small Cell Lung Cancer Therapy |
| title_fullStr | Beyond Conventional: The New Horizon of Anti-Angiogenic microRNAs in Non-Small Cell Lung Cancer Therapy |
| title_full_unstemmed | Beyond Conventional: The New Horizon of Anti-Angiogenic microRNAs in Non-Small Cell Lung Cancer Therapy |
| title_short | Beyond Conventional: The New Horizon of Anti-Angiogenic microRNAs in Non-Small Cell Lung Cancer Therapy |
| title_sort | beyond conventional the new horizon of anti angiogenic micrornas in non small cell lung cancer therapy |
| topic | microRNA miRNA ncRNA lung cancer NSCLC angiogenesis |
| url | https://www.mdpi.com/1422-0067/21/21/8002 |
| work_keys_str_mv | AT alexandrutirpe beyondconventionalthenewhorizonofantiangiogenicmicrornasinnonsmallcelllungcancertherapy AT dianagulei beyondconventionalthenewhorizonofantiangiogenicmicrornasinnonsmallcelllungcancertherapy AT georgerazvantirpe beyondconventionalthenewhorizonofantiangiogenicmicrornasinnonsmallcelllungcancertherapy AT andreeanutu beyondconventionalthenewhorizonofantiangiogenicmicrornasinnonsmallcelllungcancertherapy AT alexandruirimie beyondconventionalthenewhorizonofantiangiogenicmicrornasinnonsmallcelllungcancertherapy AT paolacampomenosi beyondconventionalthenewhorizonofantiangiogenicmicrornasinnonsmallcelllungcancertherapy AT lauraancutapop beyondconventionalthenewhorizonofantiangiogenicmicrornasinnonsmallcelllungcancertherapy AT ioanaberindanneagoe beyondconventionalthenewhorizonofantiangiogenicmicrornasinnonsmallcelllungcancertherapy |