Battle royale: Immune response on biofilms – host-pathogen interactions
The research interest of the scientific community in biofilm-forming microorganisms is growing due to the problems caused by their infections affecting humans and animals, mainly because of the difficulty of the host immune system in eradicating these microbial complex communities and the increasing...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Current Research in Immunology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590255523000033 |
| _version_ | 1797422511194898432 |
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| author | Sandra Pamela Cangui-Panchi Anahí Lizbeth Ñacato-Toapanta Leonardo Joshué Enríquez-Martínez Gabriela Alexandra Salinas-Delgado Jorge Reyes Daniel Garzon-Chavez António Machado |
| author_facet | Sandra Pamela Cangui-Panchi Anahí Lizbeth Ñacato-Toapanta Leonardo Joshué Enríquez-Martínez Gabriela Alexandra Salinas-Delgado Jorge Reyes Daniel Garzon-Chavez António Machado |
| author_sort | Sandra Pamela Cangui-Panchi |
| collection | DOAJ |
| description | The research interest of the scientific community in biofilm-forming microorganisms is growing due to the problems caused by their infections affecting humans and animals, mainly because of the difficulty of the host immune system in eradicating these microbial complex communities and the increasing antimicrobial resistance rates worldwide. This review describes the virulence factors and their interaction with the microbial communities of four well-known and highly biofilm-forming pathogens, more exactly, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus spp., and Candida spp. The innate and adaptive immune responses caused by the infection with these microorganisms and their evasion to the host immune system by biofilm formation are discussed in the present work. The relevance of the differences in the expression of certain virulence factors and the immune response in biofilm-associated infections when compared to planktonic infections is usually described as the biofilm architecture protects the pathogen and alters the host immune responses, here we extensively discussed these mechanisms. |
| first_indexed | 2024-03-09T07:34:24Z |
| format | Article |
| id | doaj.art-8d1d8794517d404c8c22af2642252e06 |
| institution | Directory Open Access Journal |
| issn | 2590-2555 |
| language | English |
| last_indexed | 2024-03-09T07:34:24Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Immunology |
| spelling | doaj.art-8d1d8794517d404c8c22af2642252e062023-12-03T05:42:48ZengElsevierCurrent Research in Immunology2590-25552023-01-014100057Battle royale: Immune response on biofilms – host-pathogen interactionsSandra Pamela Cangui-Panchi0Anahí Lizbeth Ñacato-Toapanta1Leonardo Joshué Enríquez-Martínez2Gabriela Alexandra Salinas-Delgado3Jorge Reyes4Daniel Garzon-Chavez5António Machado6Universidad San Francisco de Quito USFQ, Colegio de Ciencias Biológicas y Ambientales COCIBA, Instituto de Microbiología, Laboratorio de Bacteriología, Quito, EcuadorUniversidad San Francisco de Quito USFQ, Colegio de Ciencias Biológicas y Ambientales COCIBA, Instituto de Microbiología, Laboratorio de Bacteriología, Quito, EcuadorUniversidad San Francisco de Quito USFQ, Colegio de Ciencias Biológicas y Ambientales COCIBA, Instituto de Microbiología, Laboratorio de Bacteriología, Quito, EcuadorUniversidad San Francisco de Quito USFQ, Colegio de Ciencias Biológicas y Ambientales COCIBA, Instituto de Microbiología, Laboratorio de Bacteriología, Quito, EcuadorHospital del Instituto Ecuatoriano de Seguridad Social (IESS) Quito-Sur, Quito, Ecuador; Facultad de Ciencias Químicas, Universidad Central del Ecuador, Quito, EcuadorUniversidad San Francisco de Quito USFQ, Colegio de Ciencias de la Salud, Quito, EcuadorUniversidad San Francisco de Quito USFQ, Colegio de Ciencias Biológicas y Ambientales COCIBA, Instituto de Microbiología, Laboratorio de Bacteriología, Quito, Ecuador; Corresponding author.The research interest of the scientific community in biofilm-forming microorganisms is growing due to the problems caused by their infections affecting humans and animals, mainly because of the difficulty of the host immune system in eradicating these microbial complex communities and the increasing antimicrobial resistance rates worldwide. This review describes the virulence factors and their interaction with the microbial communities of four well-known and highly biofilm-forming pathogens, more exactly, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus spp., and Candida spp. The innate and adaptive immune responses caused by the infection with these microorganisms and their evasion to the host immune system by biofilm formation are discussed in the present work. The relevance of the differences in the expression of certain virulence factors and the immune response in biofilm-associated infections when compared to planktonic infections is usually described as the biofilm architecture protects the pathogen and alters the host immune responses, here we extensively discussed these mechanisms.http://www.sciencedirect.com/science/article/pii/S2590255523000033BiofilmsPseudomonas aeruginosaEscherichia coliStaphylococcus spp.Candida speciesVirulence factors |
| spellingShingle | Sandra Pamela Cangui-Panchi Anahí Lizbeth Ñacato-Toapanta Leonardo Joshué Enríquez-Martínez Gabriela Alexandra Salinas-Delgado Jorge Reyes Daniel Garzon-Chavez António Machado Battle royale: Immune response on biofilms – host-pathogen interactions Current Research in Immunology Biofilms Pseudomonas aeruginosa Escherichia coli Staphylococcus spp. Candida species Virulence factors |
| title | Battle royale: Immune response on biofilms – host-pathogen interactions |
| title_full | Battle royale: Immune response on biofilms – host-pathogen interactions |
| title_fullStr | Battle royale: Immune response on biofilms – host-pathogen interactions |
| title_full_unstemmed | Battle royale: Immune response on biofilms – host-pathogen interactions |
| title_short | Battle royale: Immune response on biofilms – host-pathogen interactions |
| title_sort | battle royale immune response on biofilms host pathogen interactions |
| topic | Biofilms Pseudomonas aeruginosa Escherichia coli Staphylococcus spp. Candida species Virulence factors |
| url | http://www.sciencedirect.com/science/article/pii/S2590255523000033 |
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