The contribution of gut-brain axis to development of neurological symptoms in COVID-19 recovered patients: A hypothesis and review of literature
The gut microbiota undergoes significant alterations in response to viral infections, particularly the novel SARS-CoV-2. As impaired gut microbiota can trigger numerous neurological disorders, we suggest that the long-term neurological symptoms of COVID-19 may be related to intestinal microbiota dis...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.983089/full |
| _version_ | 1797979113097527296 |
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| author | Kimia Vakili Mobina Fathi Shirin Yaghoobpoor Fatemeh Sayehmiri Yasaman Nazerian Amirhossein Nazerian Ashraf Mohamadkhani Pariya Khodabakhsh Gislaine Z. Réus Ramtin Hajibeygi Mostafa Rezaei-Tavirani |
| author_facet | Kimia Vakili Mobina Fathi Shirin Yaghoobpoor Fatemeh Sayehmiri Yasaman Nazerian Amirhossein Nazerian Ashraf Mohamadkhani Pariya Khodabakhsh Gislaine Z. Réus Ramtin Hajibeygi Mostafa Rezaei-Tavirani |
| author_sort | Kimia Vakili |
| collection | DOAJ |
| description | The gut microbiota undergoes significant alterations in response to viral infections, particularly the novel SARS-CoV-2. As impaired gut microbiota can trigger numerous neurological disorders, we suggest that the long-term neurological symptoms of COVID-19 may be related to intestinal microbiota disorders in these patients. Thus, we have gathered available information on how the virus can affect the microbiota of gastrointestinal systems, both in the acute and the recovery phase of the disease, and described several mechanisms through which this gut dysbiosis can lead to long-term neurological disorders, such as Guillain-Barre syndrome, chronic fatigue, psychiatric disorders such as depression and anxiety, and even neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. These mechanisms may be mediated by inflammatory cytokines, as well as certain chemicals such as gastrointestinal hormones (e.g., CCK), neurotransmitters (e.g., 5-HT), etc. (e.g., short-chain fatty acids), and the autonomic nervous system. In addition to the direct influences of the virus, repurposed medications used for COVID-19 patients can also play a role in gut dysbiosis. In conclusion, although there are many dark spots in our current knowledge of the mechanism of COVID-19-related gut-brain axis disturbance, based on available evidence, we can hypothesize that these two phenomena are more than just a coincidence and highly recommend large-scale epidemiologic studies in the future. |
| first_indexed | 2024-04-11T05:33:53Z |
| format | Article |
| id | doaj.art-8d1d8b206f9c4961a400e2c202af6cb8 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-11T05:33:53Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-8d1d8b206f9c4961a400e2c202af6cb82022-12-22T15:34:14ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-12-011210.3389/fcimb.2022.983089983089The contribution of gut-brain axis to development of neurological symptoms in COVID-19 recovered patients: A hypothesis and review of literatureKimia Vakili0Mobina Fathi1Shirin Yaghoobpoor2Fatemeh Sayehmiri3Yasaman Nazerian4Amirhossein Nazerian5Ashraf Mohamadkhani6Pariya Khodabakhsh7Gislaine Z. Réus8Ramtin Hajibeygi9Mostafa Rezaei-Tavirani10Student Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranStudent Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranStudent Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranStudent Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranSchool of Medicine, Iran University of Medical Sciences, Tehran, IranDigestive Disease Research Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranTranslational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, BrazilDepartment of Cardiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, IranProteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranThe gut microbiota undergoes significant alterations in response to viral infections, particularly the novel SARS-CoV-2. As impaired gut microbiota can trigger numerous neurological disorders, we suggest that the long-term neurological symptoms of COVID-19 may be related to intestinal microbiota disorders in these patients. Thus, we have gathered available information on how the virus can affect the microbiota of gastrointestinal systems, both in the acute and the recovery phase of the disease, and described several mechanisms through which this gut dysbiosis can lead to long-term neurological disorders, such as Guillain-Barre syndrome, chronic fatigue, psychiatric disorders such as depression and anxiety, and even neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. These mechanisms may be mediated by inflammatory cytokines, as well as certain chemicals such as gastrointestinal hormones (e.g., CCK), neurotransmitters (e.g., 5-HT), etc. (e.g., short-chain fatty acids), and the autonomic nervous system. In addition to the direct influences of the virus, repurposed medications used for COVID-19 patients can also play a role in gut dysbiosis. In conclusion, although there are many dark spots in our current knowledge of the mechanism of COVID-19-related gut-brain axis disturbance, based on available evidence, we can hypothesize that these two phenomena are more than just a coincidence and highly recommend large-scale epidemiologic studies in the future.https://www.frontiersin.org/articles/10.3389/fcimb.2022.983089/fullSARS-CoV-2COVID-19gastrointestinal microbiomegut-brain axisneurological disorders |
| spellingShingle | Kimia Vakili Mobina Fathi Shirin Yaghoobpoor Fatemeh Sayehmiri Yasaman Nazerian Amirhossein Nazerian Ashraf Mohamadkhani Pariya Khodabakhsh Gislaine Z. Réus Ramtin Hajibeygi Mostafa Rezaei-Tavirani The contribution of gut-brain axis to development of neurological symptoms in COVID-19 recovered patients: A hypothesis and review of literature Frontiers in Cellular and Infection Microbiology SARS-CoV-2 COVID-19 gastrointestinal microbiome gut-brain axis neurological disorders |
| title | The contribution of gut-brain axis to development of neurological symptoms in COVID-19 recovered patients: A hypothesis and review of literature |
| title_full | The contribution of gut-brain axis to development of neurological symptoms in COVID-19 recovered patients: A hypothesis and review of literature |
| title_fullStr | The contribution of gut-brain axis to development of neurological symptoms in COVID-19 recovered patients: A hypothesis and review of literature |
| title_full_unstemmed | The contribution of gut-brain axis to development of neurological symptoms in COVID-19 recovered patients: A hypothesis and review of literature |
| title_short | The contribution of gut-brain axis to development of neurological symptoms in COVID-19 recovered patients: A hypothesis and review of literature |
| title_sort | contribution of gut brain axis to development of neurological symptoms in covid 19 recovered patients a hypothesis and review of literature |
| topic | SARS-CoV-2 COVID-19 gastrointestinal microbiome gut-brain axis neurological disorders |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.983089/full |
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