Post COVID-19 Infection with Staphylococcus Aureus Bacteraemia: A Case Series
Staphylococcus aureus (S.aureus) is a leading bacterial pathogen, that causes deadly infections such as bacteraemia, Toxic Shock Syndrome (TSS) and endocarditis. It has been the main contributor to secondary bacterial infections during viral pandemics, greatly raising patient morbidity and fatality...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2023-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/17962/61840_CE[Ra1]_F(IS)_PF1(HB_KM)_PN(KM).pdf |
| _version_ | 1797815444282802176 |
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| author | Meruva Karthik Alekhya Abburu Kainat Aftab |
| author_facet | Meruva Karthik Alekhya Abburu Kainat Aftab |
| author_sort | Meruva Karthik |
| collection | DOAJ |
| description | Staphylococcus aureus (S.aureus) is a leading bacterial pathogen, that causes deadly infections such as bacteraemia, Toxic Shock Syndrome (TSS) and endocarditis. It has been the main contributor to secondary bacterial infections during viral pandemics, greatly raising patient morbidity and fatality rates. It is unknown how this secondary bacteraemia would affect people who have Severe Acute Respiratory Distress Syndrome Coronavirus 2 (SARS-CoV2). Herein, the authors present a series of case studies of 8 patients, (4 males and 4 females) infected with Coronavirus Disease-2019 (COVID-19) at tertiary hospital, Hyderabad, India, who eventually developed S.aureus bacteraemia with widespread seeding of secondary infections including cellulitis and abscess formation. Adult patients aged 20-60 years of age who were infected with COVID-19 from June’2022-August’2022 and had positive bacterial cultures for S.aureus during admission were included in the study. A total of eight patients hospitalised for COVID-19 with secondary bacteraemia were identified. Of these patients admitted with severe limb infections, three patients expired after a week of ongoing treatment from their blood cultures. Multivariate analysis identified the onset of bacteraemia (>4 days from date of admission) and age as significant predictors of mortality in admitted patients. Systemic Inflammatory Response Syndrome (SIRS) scoring and blood cultures were used to identify the mortality risk with p-value=0.05 statistical significance. The patients were subsequently treated with antibiotics and given conservative management, some of the patients admitted to Intensive Care Unit (ICU) who had critical co-morbidities, expired within a week of ongoing treatment. The final outcome of the present case series was that bacteraemia caused by S.aureus is associated with a high mortality rate in COVID-19 patients. More research is needed to understand the relationship between COVID-19 and secondary S.aureus bacteraemia. |
| first_indexed | 2024-03-13T08:22:47Z |
| format | Article |
| id | doaj.art-8d1e471c51e34569ae7efa5a2f4f30ce |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-03-13T08:22:47Z |
| publishDate | 2023-05-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-8d1e471c51e34569ae7efa5a2f4f30ce2023-05-31T05:52:07ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-05-01175OR01OR0410.7860/JCDR/2023/61840.17962Post COVID-19 Infection with Staphylococcus Aureus Bacteraemia: A Case SeriesMeruva Karthik0Alekhya Abburu1Kainat Aftab2Assistant Professor, Department of Internal Medicine, Kamineni Academy of Medical Sciences, Hyderabad, Telangana, India.Postgraduate Intern, Department of Internal Medicine, Kamineni Academy of Medical Sciences, Hyderabad, Telangana, India.Postgraduate Intern, Department of Internal Medicine, Kamineni Academy of Medical Sciences, Hyderabad, Telangana, India.Staphylococcus aureus (S.aureus) is a leading bacterial pathogen, that causes deadly infections such as bacteraemia, Toxic Shock Syndrome (TSS) and endocarditis. It has been the main contributor to secondary bacterial infections during viral pandemics, greatly raising patient morbidity and fatality rates. It is unknown how this secondary bacteraemia would affect people who have Severe Acute Respiratory Distress Syndrome Coronavirus 2 (SARS-CoV2). Herein, the authors present a series of case studies of 8 patients, (4 males and 4 females) infected with Coronavirus Disease-2019 (COVID-19) at tertiary hospital, Hyderabad, India, who eventually developed S.aureus bacteraemia with widespread seeding of secondary infections including cellulitis and abscess formation. Adult patients aged 20-60 years of age who were infected with COVID-19 from June’2022-August’2022 and had positive bacterial cultures for S.aureus during admission were included in the study. A total of eight patients hospitalised for COVID-19 with secondary bacteraemia were identified. Of these patients admitted with severe limb infections, three patients expired after a week of ongoing treatment from their blood cultures. Multivariate analysis identified the onset of bacteraemia (>4 days from date of admission) and age as significant predictors of mortality in admitted patients. Systemic Inflammatory Response Syndrome (SIRS) scoring and blood cultures were used to identify the mortality risk with p-value=0.05 statistical significance. The patients were subsequently treated with antibiotics and given conservative management, some of the patients admitted to Intensive Care Unit (ICU) who had critical co-morbidities, expired within a week of ongoing treatment. The final outcome of the present case series was that bacteraemia caused by S.aureus is associated with a high mortality rate in COVID-19 patients. More research is needed to understand the relationship between COVID-19 and secondary S.aureus bacteraemia.https://jcdr.net/articles/PDF/17962/61840_CE[Ra1]_F(IS)_PF1(HB_KM)_PN(KM).pdfcoronavirus disease-2019severe acute respiratory distress syndrome coronavirus 2systemic inflammatory response syndrome |
| spellingShingle | Meruva Karthik Alekhya Abburu Kainat Aftab Post COVID-19 Infection with Staphylococcus Aureus Bacteraemia: A Case Series Journal of Clinical and Diagnostic Research coronavirus disease-2019 severe acute respiratory distress syndrome coronavirus 2 systemic inflammatory response syndrome |
| title | Post COVID-19 Infection with Staphylococcus Aureus Bacteraemia: A Case Series |
| title_full | Post COVID-19 Infection with Staphylococcus Aureus Bacteraemia: A Case Series |
| title_fullStr | Post COVID-19 Infection with Staphylococcus Aureus Bacteraemia: A Case Series |
| title_full_unstemmed | Post COVID-19 Infection with Staphylococcus Aureus Bacteraemia: A Case Series |
| title_short | Post COVID-19 Infection with Staphylococcus Aureus Bacteraemia: A Case Series |
| title_sort | post covid 19 infection with staphylococcus aureus bacteraemia a case series |
| topic | coronavirus disease-2019 severe acute respiratory distress syndrome coronavirus 2 systemic inflammatory response syndrome |
| url | https://jcdr.net/articles/PDF/17962/61840_CE[Ra1]_F(IS)_PF1(HB_KM)_PN(KM).pdf |
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