Blood and Salivary Inflammatory Biomarkers Profile in Patients with Chronic Kidney Disease and Periodontal Disease: A Systematic Review
<b>Introduction:</b> Periodontitis is the most prevalent inflammatory disease worldwide. Its inflammatory levels spread systemically, which can be associated with chronic kidney disease. Biomarkers have the potential to diagnose and correlate periodontitis and chronic kidney disease, hel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Diseases |
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| Online Access: | https://www.mdpi.com/2079-9721/10/1/12 |
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| author | Lisandra Taísa Reginaldo Tavares Mariana Saavedra-Silva Joaquín Francisco López-Marcos Nélio Jorge Veiga Rogerio de Moraes Castilho Gustavo Vicentis de Oliveira Fernandes |
| author_facet | Lisandra Taísa Reginaldo Tavares Mariana Saavedra-Silva Joaquín Francisco López-Marcos Nélio Jorge Veiga Rogerio de Moraes Castilho Gustavo Vicentis de Oliveira Fernandes |
| author_sort | Lisandra Taísa Reginaldo Tavares |
| collection | DOAJ |
| description | <b>Introduction:</b> Periodontitis is the most prevalent inflammatory disease worldwide. Its inflammatory levels spread systemically, which can be associated with chronic kidney disease. Biomarkers have the potential to diagnose and correlate periodontitis and chronic kidney disease, helping to monitor systemic inflammation. Thereby, this study aimed to analyze the association between chronic kidney disease and periodontitis by conducting a biomarker analysis on blood and saliva. <b>Material and methods:</b> An electronic search through PubMed/MEDLINE, EMBASE, and Web of Science databases was conducted to identify clinical studies published in the last ten years, with no language restrictions. Twelve articles met all the inclusion criteria, two randomized controlled trials, one cohort study, and nine observational studies. <b>Results:</b> The studies included a total of 117 patients for saliva biomarkers, with a mean age of approximately 57 years old, and 56.68% of the subjects were female. After analyzing all the included studies, it was possible to verify the following biomarkers assessed: CRP, WBC, fibrinogen, IL-4 and -6, cardiac troponin T, NOx, ADMA, albumin, osteocalcin, cystatin C, PGLYRP1, cholesterol, HDL, LDL, triglycerides, and hemoglobin. <b>Conclusion:</b> A direct cause–effect association between periodontitis and CKD could not be established. However, it was possible to conclude that there was a correlating effect present, through the analyzed biomarkers. |
| first_indexed | 2024-03-09T13:46:18Z |
| format | Article |
| id | doaj.art-8d1e495260a54d478e3f2b3ffd25892e |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-03-09T13:46:18Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-8d1e495260a54d478e3f2b3ffd25892e2023-11-30T20:59:35ZengMDPI AGDiseases2079-97212022-02-011011210.3390/diseases10010012Blood and Salivary Inflammatory Biomarkers Profile in Patients with Chronic Kidney Disease and Periodontal Disease: A Systematic ReviewLisandra Taísa Reginaldo Tavares0Mariana Saavedra-Silva1Joaquín Francisco López-Marcos2Nélio Jorge Veiga3Rogerio de Moraes Castilho4Gustavo Vicentis de Oliveira Fernandes5Departamento de Cirurgía (Área de Estomatología), Facultad de Medicina, Universidad de Salamanca, 37007 Salamanca, SpainBiomedicine at the Medical Science Department, University of Beira Interior, 6201-506 Covilhã, PortugalDepartamento de Cirurgía (Área de Estomatología), Facultad de Medicina, Universidad de Salamanca, 37007 Salamanca, SpainCenter for Interdisciplinary Research in Health (CIIS), Facultade de Medicina Dentária, Universidade Católica, 3504-505 Viseu, PortugalPeriodontics and Oral Medicine Department, University of Michigan, Ann Arbor, MI 48109, USAPeriodontics and Oral Medicine Department, University of Michigan, Ann Arbor, MI 48109, USA<b>Introduction:</b> Periodontitis is the most prevalent inflammatory disease worldwide. Its inflammatory levels spread systemically, which can be associated with chronic kidney disease. Biomarkers have the potential to diagnose and correlate periodontitis and chronic kidney disease, helping to monitor systemic inflammation. Thereby, this study aimed to analyze the association between chronic kidney disease and periodontitis by conducting a biomarker analysis on blood and saliva. <b>Material and methods:</b> An electronic search through PubMed/MEDLINE, EMBASE, and Web of Science databases was conducted to identify clinical studies published in the last ten years, with no language restrictions. Twelve articles met all the inclusion criteria, two randomized controlled trials, one cohort study, and nine observational studies. <b>Results:</b> The studies included a total of 117 patients for saliva biomarkers, with a mean age of approximately 57 years old, and 56.68% of the subjects were female. After analyzing all the included studies, it was possible to verify the following biomarkers assessed: CRP, WBC, fibrinogen, IL-4 and -6, cardiac troponin T, NOx, ADMA, albumin, osteocalcin, cystatin C, PGLYRP1, cholesterol, HDL, LDL, triglycerides, and hemoglobin. <b>Conclusion:</b> A direct cause–effect association between periodontitis and CKD could not be established. However, it was possible to conclude that there was a correlating effect present, through the analyzed biomarkers.https://www.mdpi.com/2079-9721/10/1/12chronic kidney diseaseperiodontitisbiomarkerssystematic reviewproteins |
| spellingShingle | Lisandra Taísa Reginaldo Tavares Mariana Saavedra-Silva Joaquín Francisco López-Marcos Nélio Jorge Veiga Rogerio de Moraes Castilho Gustavo Vicentis de Oliveira Fernandes Blood and Salivary Inflammatory Biomarkers Profile in Patients with Chronic Kidney Disease and Periodontal Disease: A Systematic Review Diseases chronic kidney disease periodontitis biomarkers systematic review proteins |
| title | Blood and Salivary Inflammatory Biomarkers Profile in Patients with Chronic Kidney Disease and Periodontal Disease: A Systematic Review |
| title_full | Blood and Salivary Inflammatory Biomarkers Profile in Patients with Chronic Kidney Disease and Periodontal Disease: A Systematic Review |
| title_fullStr | Blood and Salivary Inflammatory Biomarkers Profile in Patients with Chronic Kidney Disease and Periodontal Disease: A Systematic Review |
| title_full_unstemmed | Blood and Salivary Inflammatory Biomarkers Profile in Patients with Chronic Kidney Disease and Periodontal Disease: A Systematic Review |
| title_short | Blood and Salivary Inflammatory Biomarkers Profile in Patients with Chronic Kidney Disease and Periodontal Disease: A Systematic Review |
| title_sort | blood and salivary inflammatory biomarkers profile in patients with chronic kidney disease and periodontal disease a systematic review |
| topic | chronic kidney disease periodontitis biomarkers systematic review proteins |
| url | https://www.mdpi.com/2079-9721/10/1/12 |
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