Diversity of respiratory impedance based on quantitative computed tomography in patients with COPD
Yosuke Wada,1 Yoshiaki Kitaguchi,1 Masanori Yasuo,1 Fumika Ueno,1 Satoshi Kawakami,2 Kiyoyasu Fukushima,3 Keisaku Fujimoto,4 Masayuki Hanaoka1 1First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan; 2Department of Radiology, Shinshu University School...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2018-06-01
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| Series: | International Journal of COPD |
| Subjects: | |
| Online Access: | https://www.dovepress.com/diversity-of-respiratory-impedance-based-on-quantitative-computed-tomo-peer-reviewed-article-COPD |
| _version_ | 1818498093597851648 |
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| author | Wada Y Kitaguchi Y Yasuo M Ueno F Kawakami S Fukushima K Fujimoto K Hanaoka M |
| author_facet | Wada Y Kitaguchi Y Yasuo M Ueno F Kawakami S Fukushima K Fujimoto K Hanaoka M |
| author_sort | Wada Y |
| collection | DOAJ |
| description | Yosuke Wada,1 Yoshiaki Kitaguchi,1 Masanori Yasuo,1 Fumika Ueno,1 Satoshi Kawakami,2 Kiyoyasu Fukushima,3 Keisaku Fujimoto,4 Masayuki Hanaoka1 1First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan; 2Department of Radiology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan; 3Department of Respiratory Medicine, Japanese Red Cross Nagasaki Genbaku Isahaya Hospital, Isahaya, Nagasaki, Japan; 4Departments of Clinical Laboratory Sciences, Shinshu University School of Health Sciences, Matsumoto, Nagano, Japan Introduction: This study was conducted in order to investigate the diversity of respiratory physiology, including the respiratory impedance and reversibility of airway obstruction, based on quantitative computed tomography (CT) in patients with COPD. Patients and methods: Medical records of 174 stable COPD patients were retrospectively reviewed to obtain the patients’ clinical data, including the pulmonary function and imaging data. According to the software-based quantification of the degree of emphysema and airway wall thickness, the patients were classified into the “normal by CT” phenotype, the airway-dominant phenotype, the emphysema-dominant phenotype, and the mixed phenotype. The pulmonary function, including the respiratory impedance evaluated by using the forced oscillation technique (FOT) and the reversibility of airway obstruction in response to inhaled short-acting β2-agonists, was then compared among the four phenotypes. Results: The respiratory system resistance at 5 and 20 Hz (R5 and R20) was significantly higher, and the respiratory system reactance at 5 Hz (X5) was significantly more negative in the airway-dominant and mixed phenotypes than in the other phenotypes. The within-breath changes of X5 (ΔX5) were significantly greater in the mixed phenotype than in the “normal by CT” and emphysema-dominant phenotypes. The FOT parameters (R5, R20, and X5) were significantly correlated with indices of the degree of airway wall thickness and significantly but weakly correlated with the reversibility of airway obstruction. There was no significant correlation between the FOT parameters (R5, R20, and X5) and the degree of emphysema. Conclusion: There is a diversity of respiratory physiology, including the respiratory impedance and reversibility of airway obstruction, based on quantitative CT in patients with COPD. The FOT measurements may reflect the degree of airway disease and aid in detecting airway remodeling in patients with COPD. Keywords: FOT, respiratory impedance, MostGraph, AWT-Pi10 |
| first_indexed | 2024-12-10T18:53:39Z |
| format | Article |
| id | doaj.art-8d1f19e35baf4d3db3a450362b1e1aae |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-12-10T18:53:39Z |
| publishDate | 2018-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-8d1f19e35baf4d3db3a450362b1e1aae2022-12-22T01:37:14ZengDove Medical PressInternational Journal of COPD1178-20052018-06-01Volume 131841184938658Diversity of respiratory impedance based on quantitative computed tomography in patients with COPDWada YKitaguchi YYasuo MUeno FKawakami SFukushima KFujimoto KHanaoka MYosuke Wada,1 Yoshiaki Kitaguchi,1 Masanori Yasuo,1 Fumika Ueno,1 Satoshi Kawakami,2 Kiyoyasu Fukushima,3 Keisaku Fujimoto,4 Masayuki Hanaoka1 1First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan; 2Department of Radiology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan; 3Department of Respiratory Medicine, Japanese Red Cross Nagasaki Genbaku Isahaya Hospital, Isahaya, Nagasaki, Japan; 4Departments of Clinical Laboratory Sciences, Shinshu University School of Health Sciences, Matsumoto, Nagano, Japan Introduction: This study was conducted in order to investigate the diversity of respiratory physiology, including the respiratory impedance and reversibility of airway obstruction, based on quantitative computed tomography (CT) in patients with COPD. Patients and methods: Medical records of 174 stable COPD patients were retrospectively reviewed to obtain the patients’ clinical data, including the pulmonary function and imaging data. According to the software-based quantification of the degree of emphysema and airway wall thickness, the patients were classified into the “normal by CT” phenotype, the airway-dominant phenotype, the emphysema-dominant phenotype, and the mixed phenotype. The pulmonary function, including the respiratory impedance evaluated by using the forced oscillation technique (FOT) and the reversibility of airway obstruction in response to inhaled short-acting β2-agonists, was then compared among the four phenotypes. Results: The respiratory system resistance at 5 and 20 Hz (R5 and R20) was significantly higher, and the respiratory system reactance at 5 Hz (X5) was significantly more negative in the airway-dominant and mixed phenotypes than in the other phenotypes. The within-breath changes of X5 (ΔX5) were significantly greater in the mixed phenotype than in the “normal by CT” and emphysema-dominant phenotypes. The FOT parameters (R5, R20, and X5) were significantly correlated with indices of the degree of airway wall thickness and significantly but weakly correlated with the reversibility of airway obstruction. There was no significant correlation between the FOT parameters (R5, R20, and X5) and the degree of emphysema. Conclusion: There is a diversity of respiratory physiology, including the respiratory impedance and reversibility of airway obstruction, based on quantitative CT in patients with COPD. The FOT measurements may reflect the degree of airway disease and aid in detecting airway remodeling in patients with COPD. Keywords: FOT, respiratory impedance, MostGraph, AWT-Pi10https://www.dovepress.com/diversity-of-respiratory-impedance-based-on-quantitative-computed-tomo-peer-reviewed-article-COPDFOTrespiratory impedanceMostGraphAWT-Pi10 |
| spellingShingle | Wada Y Kitaguchi Y Yasuo M Ueno F Kawakami S Fukushima K Fujimoto K Hanaoka M Diversity of respiratory impedance based on quantitative computed tomography in patients with COPD International Journal of COPD FOT respiratory impedance MostGraph AWT-Pi10 |
| title | Diversity of respiratory impedance based on quantitative computed tomography in patients with COPD |
| title_full | Diversity of respiratory impedance based on quantitative computed tomography in patients with COPD |
| title_fullStr | Diversity of respiratory impedance based on quantitative computed tomography in patients with COPD |
| title_full_unstemmed | Diversity of respiratory impedance based on quantitative computed tomography in patients with COPD |
| title_short | Diversity of respiratory impedance based on quantitative computed tomography in patients with COPD |
| title_sort | diversity of respiratory impedance based on quantitative computed tomography in patients with copd |
| topic | FOT respiratory impedance MostGraph AWT-Pi10 |
| url | https://www.dovepress.com/diversity-of-respiratory-impedance-based-on-quantitative-computed-tomo-peer-reviewed-article-COPD |
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