Cardiac Remodeling and Its Determinants in Anorexia Nervosa Adolescents: Impact of Weight Recovery
Cardiovascular alterations in anorexia nervosa (AN) adolescents include bradycardia and decreased systolic blood pressure and left ventricular mass. However, their determinants remain poorly understood. We assessed the associations between morphological and functional left ventricular (LV) remodelin...
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MDPI AG
2022-03-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/4/458 |
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| author | Justine Paysal Jérôme Thireau Daniel Terral Emmanuelle Rochette Philippe Obert Etienne Merlin Stéphane Nottin |
| author_facet | Justine Paysal Jérôme Thireau Daniel Terral Emmanuelle Rochette Philippe Obert Etienne Merlin Stéphane Nottin |
| author_sort | Justine Paysal |
| collection | DOAJ |
| description | Cardiovascular alterations in anorexia nervosa (AN) adolescents include bradycardia and decreased systolic blood pressure and left ventricular mass. However, their determinants remain poorly understood. We assessed the associations between morphological and functional left ventricular (LV) remodeling, autonomic control by heart rate variability (HRV) analysis, thyroid hormones and brain natriuretic peptide (BNP) levels in AN female adolescents without or with weight recovery (WR). Fifty-nine female adolescents including 16 AN patients without WR (mean age 13.9 years (10–16)), 10 AN patients with WR (15.7 years (12–18)) and 33 controls (14.1 years (10–18)) underwent night heart rate (HR) recording to measure HRV (and especially SD1/SD2, the ratio between instantaneous (SD1) and long-term (SD2) standard deviation of R-R intervals, reflecting sympatho-vagal balance), speckle tracking echocardiography to assess LV global longitudinal strain (GLS) and blood test for dosage of tri-iodothyronine (T3) hormone and NT-proBNP. Compared to controls, AN patients without WR presented with lower HR (55 ± 7 vs. 68 ± 6 bpm; <i>p</i> < 0.001), parasympathetic hyperactivity, and higher GLS (−19.2 ± 1.8 vs. −16.9 ± 2.8%; <i>p</i> = 0.009). These alterations were partly abolished in AN patients with WR. In a multivariate regression analysis, T3 was the main factor explaining the variance of SD1/SD2, a sympatho-vagal balance marker. NT-proBNP levels were not correlated with cardiac alterations. AN patients had parasympathetic hyperactivity linked with their rate of T3, and a higher GLS. These alterations were partly restored in AN patients with WR. |
| first_indexed | 2024-03-09T11:01:19Z |
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| language | English |
| last_indexed | 2024-03-09T11:01:19Z |
| publishDate | 2022-03-01 |
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| series | Children |
| spelling | doaj.art-8d205cf6a5fa41a89b1b5d6fcb3673452023-12-01T01:17:20ZengMDPI AGChildren2227-90672022-03-019445810.3390/children9040458Cardiac Remodeling and Its Determinants in Anorexia Nervosa Adolescents: Impact of Weight RecoveryJustine Paysal0Jérôme Thireau1Daniel Terral2Emmanuelle Rochette3Philippe Obert4Etienne Merlin5Stéphane Nottin6LAPEC UPR 4278, Avignon University, 84000 Avignon, FranceCNRS, INSERM, PhyMedExp, University of Montpellier, 34000 Montpellier, FrancePédiatrie, CHU Clermont-Ferrand, 63000 Clermont-Ferrand, FrancePédiatrie, CHU Clermont-Ferrand, 63000 Clermont-Ferrand, FranceLAPEC UPR 4278, Avignon University, 84000 Avignon, FrancePédiatrie, CHU Clermont-Ferrand, 63000 Clermont-Ferrand, FranceLAPEC UPR 4278, Avignon University, 84000 Avignon, FranceCardiovascular alterations in anorexia nervosa (AN) adolescents include bradycardia and decreased systolic blood pressure and left ventricular mass. However, their determinants remain poorly understood. We assessed the associations between morphological and functional left ventricular (LV) remodeling, autonomic control by heart rate variability (HRV) analysis, thyroid hormones and brain natriuretic peptide (BNP) levels in AN female adolescents without or with weight recovery (WR). Fifty-nine female adolescents including 16 AN patients without WR (mean age 13.9 years (10–16)), 10 AN patients with WR (15.7 years (12–18)) and 33 controls (14.1 years (10–18)) underwent night heart rate (HR) recording to measure HRV (and especially SD1/SD2, the ratio between instantaneous (SD1) and long-term (SD2) standard deviation of R-R intervals, reflecting sympatho-vagal balance), speckle tracking echocardiography to assess LV global longitudinal strain (GLS) and blood test for dosage of tri-iodothyronine (T3) hormone and NT-proBNP. Compared to controls, AN patients without WR presented with lower HR (55 ± 7 vs. 68 ± 6 bpm; <i>p</i> < 0.001), parasympathetic hyperactivity, and higher GLS (−19.2 ± 1.8 vs. −16.9 ± 2.8%; <i>p</i> = 0.009). These alterations were partly abolished in AN patients with WR. In a multivariate regression analysis, T3 was the main factor explaining the variance of SD1/SD2, a sympatho-vagal balance marker. NT-proBNP levels were not correlated with cardiac alterations. AN patients had parasympathetic hyperactivity linked with their rate of T3, and a higher GLS. These alterations were partly restored in AN patients with WR.https://www.mdpi.com/2227-9067/9/4/458speckle tracking echocardiographyheart rate variabilitythyroid hormonesanorexia nervosa |
| spellingShingle | Justine Paysal Jérôme Thireau Daniel Terral Emmanuelle Rochette Philippe Obert Etienne Merlin Stéphane Nottin Cardiac Remodeling and Its Determinants in Anorexia Nervosa Adolescents: Impact of Weight Recovery Children speckle tracking echocardiography heart rate variability thyroid hormones anorexia nervosa |
| title | Cardiac Remodeling and Its Determinants in Anorexia Nervosa Adolescents: Impact of Weight Recovery |
| title_full | Cardiac Remodeling and Its Determinants in Anorexia Nervosa Adolescents: Impact of Weight Recovery |
| title_fullStr | Cardiac Remodeling and Its Determinants in Anorexia Nervosa Adolescents: Impact of Weight Recovery |
| title_full_unstemmed | Cardiac Remodeling and Its Determinants in Anorexia Nervosa Adolescents: Impact of Weight Recovery |
| title_short | Cardiac Remodeling and Its Determinants in Anorexia Nervosa Adolescents: Impact of Weight Recovery |
| title_sort | cardiac remodeling and its determinants in anorexia nervosa adolescents impact of weight recovery |
| topic | speckle tracking echocardiography heart rate variability thyroid hormones anorexia nervosa |
| url | https://www.mdpi.com/2227-9067/9/4/458 |
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