Comparative efficacy and safety of JAK inhibitors as monotherapy and in combination with methotrexate in patients with active rheumatoid arthritis: A systematic review and meta-analysis

Comparative efficacy and safety of JAK inhibitors as monotherapy and in combination with methotrexate in patients with active rheumatoid arthritis: A systematic review and meta-analysis

BackgroundWe aim to evaluate the efficacy and tolerability of Janus kinase inhibitors (JAKi) as monotherapy and in combination with methotrexate (MTX) in active rheumatoid arthritis (RA).MethodsMedline, EMBASE, and Cochrane Library were systematically searched to identify relevant randomized control...

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Bibliographic Details
Main Authors: Li Liu, Yi-Dan Yan, Fang-Hong Shi, Hou-Wen Lin, Zhi-Chun Gu, Jia Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
janus kinase inhibitors
monotherapy
combination therapy
methotrexate
rheumatoid arthritis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.977265/full

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