Lactiplantibacillus plantarum APsulloc 331261 (GTB1TM) attenuates depressive-like behavior and physiology via association with gut microbiota in BALB/c mice
As it has become clear that the gut microbiota play a critical role in brain function, probiotics have recently been spotlighted as therapeutic agents for various psychiatric disorders including major depressive disorder. Despite much interest, however, our understanding of the efficacy of probiotic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646462300292X |
| _version_ | 1797749118162960384 |
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| author | Yuri Lee Subin Yeo Bobae Kim Wilhelm H. Holzapfel Hye-Ji Kang |
| author_facet | Yuri Lee Subin Yeo Bobae Kim Wilhelm H. Holzapfel Hye-Ji Kang |
| author_sort | Yuri Lee |
| collection | DOAJ |
| description | As it has become clear that the gut microbiota play a critical role in brain function, probiotics have recently been spotlighted as therapeutic agents for various psychiatric disorders including major depressive disorder. Despite much interest, however, our understanding of the efficacy of probiotics for treating depression is still limited due to the complexity of the gut-brain axis. The present study aimed to evaluate the anti-depressive effect of Lactiplantibacillus plantarum APsulloc 331,261 in vivo and to elucidate the possible mechanism of action of this strain. The consumption of the strain APsulloc 331,261 could significantly reduce depressive-like behaviors and downregulate hippocampal inflammation. Interestingly, administration of the strain shifted the gut microbial community towards increasing acetate and propionate production. This modulation might stimulate increased serotonin synthesis in the colon and increase the serotonin level and neurogenesis in the brain. These results may serve to support the proposal of a new probiotic candidate strain for ameliorating depression. |
| first_indexed | 2024-03-12T16:15:38Z |
| format | Article |
| id | doaj.art-8d2346fd46d844f7a56b09ada038d68a |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-12T16:15:38Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-8d2346fd46d844f7a56b09ada038d68a2023-08-09T04:32:37ZengElsevierJournal of Functional Foods1756-46462023-08-01107105692Lactiplantibacillus plantarum APsulloc 331261 (GTB1TM) attenuates depressive-like behavior and physiology via association with gut microbiota in BALB/c miceYuri Lee0Subin Yeo1Bobae Kim2Wilhelm H. Holzapfel3Hye-Ji Kang4Graduate School of Advanced Convergence, Handong Global University, Pohang, Republic of KoreaHEM Pharma, Pohang, Republic of KoreaHEM Pharma, Pohang, Republic of KoreaGraduate School of Advanced Convergence, Handong Global University, Pohang, Republic of Korea; Corresponding authors at: Graduate School of Advanced Convergence, Handong Global University, Pohang, Republic of Korea (H.-J. Kang).Graduate School of Advanced Convergence, Handong Global University, Pohang, Republic of Korea; HEM Pharma, Pohang, Republic of Korea; Corresponding authors at: Graduate School of Advanced Convergence, Handong Global University, Pohang, Republic of Korea (H.-J. Kang).As it has become clear that the gut microbiota play a critical role in brain function, probiotics have recently been spotlighted as therapeutic agents for various psychiatric disorders including major depressive disorder. Despite much interest, however, our understanding of the efficacy of probiotics for treating depression is still limited due to the complexity of the gut-brain axis. The present study aimed to evaluate the anti-depressive effect of Lactiplantibacillus plantarum APsulloc 331,261 in vivo and to elucidate the possible mechanism of action of this strain. The consumption of the strain APsulloc 331,261 could significantly reduce depressive-like behaviors and downregulate hippocampal inflammation. Interestingly, administration of the strain shifted the gut microbial community towards increasing acetate and propionate production. This modulation might stimulate increased serotonin synthesis in the colon and increase the serotonin level and neurogenesis in the brain. These results may serve to support the proposal of a new probiotic candidate strain for ameliorating depression.http://www.sciencedirect.com/science/article/pii/S175646462300292XMajor depressive disorderProbioticsGut microbiotaShort-chain fatty acidsSerotoninMicrobiota-gut-brain axis |
| spellingShingle | Yuri Lee Subin Yeo Bobae Kim Wilhelm H. Holzapfel Hye-Ji Kang Lactiplantibacillus plantarum APsulloc 331261 (GTB1TM) attenuates depressive-like behavior and physiology via association with gut microbiota in BALB/c mice Journal of Functional Foods Major depressive disorder Probiotics Gut microbiota Short-chain fatty acids Serotonin Microbiota-gut-brain axis |
| title | Lactiplantibacillus plantarum APsulloc 331261 (GTB1TM) attenuates depressive-like behavior and physiology via association with gut microbiota in BALB/c mice |
| title_full | Lactiplantibacillus plantarum APsulloc 331261 (GTB1TM) attenuates depressive-like behavior and physiology via association with gut microbiota in BALB/c mice |
| title_fullStr | Lactiplantibacillus plantarum APsulloc 331261 (GTB1TM) attenuates depressive-like behavior and physiology via association with gut microbiota in BALB/c mice |
| title_full_unstemmed | Lactiplantibacillus plantarum APsulloc 331261 (GTB1TM) attenuates depressive-like behavior and physiology via association with gut microbiota in BALB/c mice |
| title_short | Lactiplantibacillus plantarum APsulloc 331261 (GTB1TM) attenuates depressive-like behavior and physiology via association with gut microbiota in BALB/c mice |
| title_sort | lactiplantibacillus plantarum apsulloc 331261 gtb1tm attenuates depressive like behavior and physiology via association with gut microbiota in balb c mice |
| topic | Major depressive disorder Probiotics Gut microbiota Short-chain fatty acids Serotonin Microbiota-gut-brain axis |
| url | http://www.sciencedirect.com/science/article/pii/S175646462300292X |
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