Bimanual motor skill learning and robotic assistance for chronic hemiparetic stroke: a randomized controlled trial
Using robotic devices might improve recovery post-stroke, but the optimal way to apply robotic assistance has yet to be determined. The current study aimed to investigate whether training under the robotic active-assisted mode improves bimanual motor skill learning (biMSkL) more than training under...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=8;spage=1566;epage=1573;aulast=Yeganeh |
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| author | Maral Yeganeh Doost Benoît Herman Adrien Denis Julien Sapin Daniel Galinski Audrey Riga Patrice Laloux Benoît Bihin Yves Vandermeeren |
| author_facet | Maral Yeganeh Doost Benoît Herman Adrien Denis Julien Sapin Daniel Galinski Audrey Riga Patrice Laloux Benoît Bihin Yves Vandermeeren |
| author_sort | Maral Yeganeh Doost |
| collection | DOAJ |
| description | Using robotic devices might improve recovery post-stroke, but the optimal way to apply robotic assistance has yet to be determined. The current study aimed to investigate whether training under the robotic active-assisted mode improves bimanual motor skill learning (biMSkL) more than training under the active mode in stroke patients. Twenty-six healthy individuals (HI) and 23 chronic hemiparetic stroke patients with a detectable lesion on MRI or CT scan, who demonstrated motor deficits in the upper limb, were randomly allocated to two parallel groups. The protocol included a two-day training on a new bimanual cooperative task, LIFT-THE-TRAY, under either the active or active-assisted modes (where assistance decreased in a pre-determined stepwise fashion) with the bimanual version of the REAplan® robotic device. The hypothesis was that the active-assisted mode would result in greater biMSkL than the active mode. The biMSkL was quantified by a speed-accuracy trade-off (SAT) before (T1) and immediately after (T2) training on days 1 and 2 (T3 and T4). The change in SAT after 2 days of training (T4/T1) indicated that both HI and stroke patients learned and retained the bimanual cooperative task. After 2 days of training, the active-assisted mode did not improve biMSkL more than the active mode (T4/T1) in HI nor stroke patients. Whereas HI generalized the learned bimanual skill to different execution speeds in both the active and active-assisted subgroups, the stroke patients generalized the learned skill only in the active subgroup. Taken together, the active-assisted mode, applied in a pre-determined stepwise decreasing fashion, did not improve biMSkL more than the active mode in HI and stroke subjects. Stroke subjects might benefit more from robotic assistance when applied “as-needed.” This study was approved by the local ethical committee (Comité d’éthique médicale, CHU UCL Namur, Mont-Godinne, Yvoir, Belgium; Internal number: 54/2010, EudraCT number: NUB B039201317382) on July 14, 2016 and was registered with ClinicalTrials.gov (Identifier: NCT03974750) on June 5, 2019. |
| first_indexed | 2024-12-14T19:40:32Z |
| format | Article |
| id | doaj.art-8d234f80cf0d4fec96b8011ed498dc42 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-14T19:40:32Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-8d234f80cf0d4fec96b8011ed498dc422022-12-21T22:49:42ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742021-01-011681566157310.4103/1673-5374.301030Bimanual motor skill learning and robotic assistance for chronic hemiparetic stroke: a randomized controlled trialMaral Yeganeh DoostBenoît HermanAdrien DenisJulien SapinDaniel GalinskiAudrey RigaPatrice LalouxBenoît BihinYves VandermeerenUsing robotic devices might improve recovery post-stroke, but the optimal way to apply robotic assistance has yet to be determined. The current study aimed to investigate whether training under the robotic active-assisted mode improves bimanual motor skill learning (biMSkL) more than training under the active mode in stroke patients. Twenty-six healthy individuals (HI) and 23 chronic hemiparetic stroke patients with a detectable lesion on MRI or CT scan, who demonstrated motor deficits in the upper limb, were randomly allocated to two parallel groups. The protocol included a two-day training on a new bimanual cooperative task, LIFT-THE-TRAY, under either the active or active-assisted modes (where assistance decreased in a pre-determined stepwise fashion) with the bimanual version of the REAplan® robotic device. The hypothesis was that the active-assisted mode would result in greater biMSkL than the active mode. The biMSkL was quantified by a speed-accuracy trade-off (SAT) before (T1) and immediately after (T2) training on days 1 and 2 (T3 and T4). The change in SAT after 2 days of training (T4/T1) indicated that both HI and stroke patients learned and retained the bimanual cooperative task. After 2 days of training, the active-assisted mode did not improve biMSkL more than the active mode (T4/T1) in HI nor stroke patients. Whereas HI generalized the learned bimanual skill to different execution speeds in both the active and active-assisted subgroups, the stroke patients generalized the learned skill only in the active subgroup. Taken together, the active-assisted mode, applied in a pre-determined stepwise decreasing fashion, did not improve biMSkL more than the active mode in HI and stroke subjects. Stroke subjects might benefit more from robotic assistance when applied “as-needed.” This study was approved by the local ethical committee (Comité d’éthique médicale, CHU UCL Namur, Mont-Godinne, Yvoir, Belgium; Internal number: 54/2010, EudraCT number: NUB B039201317382) on July 14, 2016 and was registered with ClinicalTrials.gov (Identifier: NCT03974750) on June 5, 2019.http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=8;spage=1566;epage=1573;aulast=Yeganehbimanual; hemiparesis; motor learning; rehabilitation; robotic; robotic assistance; slacking; stroke retention |
| spellingShingle | Maral Yeganeh Doost Benoît Herman Adrien Denis Julien Sapin Daniel Galinski Audrey Riga Patrice Laloux Benoît Bihin Yves Vandermeeren Bimanual motor skill learning and robotic assistance for chronic hemiparetic stroke: a randomized controlled trial Neural Regeneration Research bimanual; hemiparesis; motor learning; rehabilitation; robotic; robotic assistance; slacking; stroke retention |
| title | Bimanual motor skill learning and robotic assistance for chronic hemiparetic stroke: a randomized controlled trial |
| title_full | Bimanual motor skill learning and robotic assistance for chronic hemiparetic stroke: a randomized controlled trial |
| title_fullStr | Bimanual motor skill learning and robotic assistance for chronic hemiparetic stroke: a randomized controlled trial |
| title_full_unstemmed | Bimanual motor skill learning and robotic assistance for chronic hemiparetic stroke: a randomized controlled trial |
| title_short | Bimanual motor skill learning and robotic assistance for chronic hemiparetic stroke: a randomized controlled trial |
| title_sort | bimanual motor skill learning and robotic assistance for chronic hemiparetic stroke a randomized controlled trial |
| topic | bimanual; hemiparesis; motor learning; rehabilitation; robotic; robotic assistance; slacking; stroke retention |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=8;spage=1566;epage=1573;aulast=Yeganeh |
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