Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild traumatic brain injury

Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild traumatic brain injury

IntroductionTraumatic brain injury (TBI) is a leading cause of disability in the US. Angiotensin 1-7 (Ang-1-7), an endogenous peptide, acts at the G protein coupled MAS1 receptors (MASR) to inhibit inflammatory mediators and decrease reactive oxygen species within the CNS. Few studies have identifie...

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Bibliographic Details
Main Authors: Ryan P. Bruhns, Maha Ibrahim Sulaiman, Michael Gaub, Esther H. Bae, Rachel B. Davidson Knapp, Anna R. Larson, Angela Smith, Deziree L. Coleman, William D. Staatz, Alexander J. Sandweiss, Bellal Joseph, Meredith Hay, Tally M. Largent-Milnes, Todd W. Vanderah
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
traumatic brain injury
angiotensin 1-7
Mas receptor
cognitive impairment
pTau
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2022.903980/full

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