An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor
Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate au...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2016-01-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/10856 |
| _version_ | 1828195371840438272 |
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| author | Yasin F Dagdas Khaoula Belhaj Abbas Maqbool Angela Chaparro-Garcia Pooja Pandey Benjamin Petre Nadra Tabassum Neftaly Cruz-Mireles Richard K Hughes Jan Sklenar Joe Win Frank Menke Kim Findlay Mark J Banfield Sophien Kamoun Tolga O Bozkurt |
| author_facet | Yasin F Dagdas Khaoula Belhaj Abbas Maqbool Angela Chaparro-Garcia Pooja Pandey Benjamin Petre Nadra Tabassum Neftaly Cruz-Mireles Richard K Hughes Jan Sklenar Joe Win Frank Menke Kim Findlay Mark J Banfield Sophien Kamoun Tolga O Bozkurt |
| author_sort | Yasin F Dagdas |
| collection | DOAJ |
| description | Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses. |
| first_indexed | 2024-04-12T09:41:07Z |
| format | Article |
| id | doaj.art-8d24812844294c499db8f4bb6d9650e3 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T09:41:07Z |
| publishDate | 2016-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-8d24812844294c499db8f4bb6d9650e32022-12-22T03:38:03ZengeLife Sciences Publications LtdeLife2050-084X2016-01-01510.7554/eLife.10856An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptorYasin F Dagdas0https://orcid.org/0000-0002-9502-355XKhaoula Belhaj1Abbas Maqbool2Angela Chaparro-Garcia3Pooja Pandey4Benjamin Petre5Nadra Tabassum6https://orcid.org/0000-0002-2722-9441Neftaly Cruz-Mireles7Richard K Hughes8Jan Sklenar9Joe Win10Frank Menke11Kim Findlay12Mark J Banfield13https://orcid.org/0000-0001-8921-3835Sophien Kamoun14https://orcid.org/0000-0002-0290-0315Tolga O Bozkurt15The Sainsbury Laboratory, Norwich, United KingdomThe Sainsbury Laboratory, Norwich, United KingdomDepartment of Biological Chemistry, John Innes Centre, Norwich, United KingdomThe Sainsbury Laboratory, Norwich, United KingdomDepartment of Life Sciences, Imperial College London, London, United KingdomThe Sainsbury Laboratory, Norwich, United KingdomDepartment of Life Sciences, Imperial College London, London, United KingdomThe Sainsbury Laboratory, Norwich, United KingdomDepartment of Biological Chemistry, John Innes Centre, Norwich, United KingdomThe Sainsbury Laboratory, Norwich, United KingdomThe Sainsbury Laboratory, Norwich, United KingdomThe Sainsbury Laboratory, Norwich, United KingdomDepartment of Cell and Developmental Biology, John Innes Centre, Norwich, United KingdomDepartment of Biological Chemistry, John Innes Centre, Norwich, United KingdomThe Sainsbury Laboratory, Norwich, United KingdomThe Sainsbury Laboratory, Norwich, United Kingdom; Department of Life Sciences, Imperial College London, London, United KingdomPlants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses.https://elifesciences.org/articles/10856Nicotiana benthamianaPhytophthora infestansautophagyeffectorsIrish potato faminelate blight disease |
| spellingShingle | Yasin F Dagdas Khaoula Belhaj Abbas Maqbool Angela Chaparro-Garcia Pooja Pandey Benjamin Petre Nadra Tabassum Neftaly Cruz-Mireles Richard K Hughes Jan Sklenar Joe Win Frank Menke Kim Findlay Mark J Banfield Sophien Kamoun Tolga O Bozkurt An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor eLife Nicotiana benthamiana Phytophthora infestans autophagy effectors Irish potato famine late blight disease |
| title | An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor |
| title_full | An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor |
| title_fullStr | An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor |
| title_full_unstemmed | An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor |
| title_short | An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor |
| title_sort | effector of the irish potato famine pathogen antagonizes a host autophagy cargo receptor |
| topic | Nicotiana benthamiana Phytophthora infestans autophagy effectors Irish potato famine late blight disease |
| url | https://elifesciences.org/articles/10856 |
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