Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity
Several aliphatic and aromatic lactones and two dimers were synthesized using the sequence: allylation - esterification - metathesis. These compounds were active in vitro against intracellular amastigotes of Leishmania panamensis. The structure-activity relationship showed the importance of the alip...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2009-07-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/14/7/2491/ |
| _version_ | 1828758108445343744 |
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| author | Fernando Echeverri Wilson Cardona Sara Robledo Winston Quiñones Marcela Castaño |
| author_facet | Fernando Echeverri Wilson Cardona Sara Robledo Winston Quiñones Marcela Castaño |
| author_sort | Fernando Echeverri |
| collection | DOAJ |
| description | Several aliphatic and aromatic lactones and two dimers were synthesized using the sequence: allylation - esterification - metathesis. These compounds were active in vitro against intracellular amastigotes of Leishmania panamensis. The structure-activity relationship showed the importance of the aliphatic side chain to enhance the biological activity and to obtain lower cytotoxicity. It was also observed that a decrease in the size of the lactone ring increases the selectivity index. |
| first_indexed | 2024-12-11T00:37:02Z |
| format | Article |
| id | doaj.art-8d28ffbbcfa34d11944356eada6e1bc9 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T00:37:02Z |
| publishDate | 2009-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8d28ffbbcfa34d11944356eada6e1bc92022-12-22T01:27:07ZengMDPI AGMolecules1420-30492009-07-011472491250010.3390/molecules14072491Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-ActivityFernando EcheverriWilson CardonaSara RobledoWinston QuiñonesMarcela CastañoSeveral aliphatic and aromatic lactones and two dimers were synthesized using the sequence: allylation - esterification - metathesis. These compounds were active in vitro against intracellular amastigotes of Leishmania panamensis. The structure-activity relationship showed the importance of the aliphatic side chain to enhance the biological activity and to obtain lower cytotoxicity. It was also observed that a decrease in the size of the lactone ring increases the selectivity index.http://www.mdpi.com/1420-3049/14/7/2491/metathesislactonesantiparasiteleishmania |
| spellingShingle | Fernando Echeverri Wilson Cardona Sara Robledo Winston Quiñones Marcela Castaño Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity Molecules metathesis lactones antiparasite leishmania |
| title | Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity |
| title_full | Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity |
| title_fullStr | Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity |
| title_full_unstemmed | Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity |
| title_short | Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity |
| title_sort | leishmanicidal activity of aliphatic and aromatic lactones correlation structure activity |
| topic | metathesis lactones antiparasite leishmania |
| url | http://www.mdpi.com/1420-3049/14/7/2491/ |
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