Comet Assay: A Method to Evaluate Genotoxicity of Nano-Drug Delivery System

Comet Assay: A Method to Evaluate Genotoxicity of Nano-Drug Delivery System

Introduction: Drug delivery systems could induce cellular toxicity as side effect of nanomaterials. The mechanism of toxicity usually involves DNA damage. The comet assay or single cell gel electrophoresis (SCGE) is a sensitive method for detecting strand damages in the DNA of a cell with applicatio...

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Bibliographic Details
Main Authors: Morteza Eskandani, Somayeh Vandghanooni
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2011-08-01
Series:BioImpacts
Subjects:
Nanoparticle
Drug Delivery
Genotoxicity
Comet Assay
Single Cell Gel Electrophoresis
DNA
Online Access:http://dx.doi.org/10.5681/bi.2011.012

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