Carbogen Breathing Differentially Enhances Blood Plasma Volume and 5-Fluorouracil Uptake in Two Murine Colon Tumor Models with a Distinct Vascular Structure

Carbogen Breathing Differentially Enhances Blood Plasma Volume and 5-Fluorouracil Uptake in Two Murine Colon Tumor Models with a Distinct Vascular Structure

For the systemic treatment of colorectal cancer, 5-fluorouracil (FU)-based chemotherapy is the standard. However, only a subset of patients responds to chemotherapy. Breathing of carbogen (95% O2 and 5% CO2) may increase the uptake of FU through changes in tumor physiology. This study aims to monito...

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Bibliographic Details
Main Authors: Hanneke W.M. van Laarhoven, Giulio Gambarota, Jasper Lok, Martin Lammens, Yvonne L.M. Kamm, Theo Wagener, Cornelis J.A. Punt, Albert J. van der Kogel, Arend Heerschap
Format: Article
Language:English
Published: Elsevier 2006-06-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Carbogen
colon carcinoma
5-fluorouracil
19F MRS
31P MRS
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800308

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