Impacts of eosinophil percentage on prognosis acute type A aortic dissection patients
Abstract Background Eosinophils are pro-inflammatory cells involved in thrombosis and have been proposed as a prognosis marker in acute ischemic stroke and ST-elevation myocardial Infarction. Here, we sought to clarify the prognostic value of eosinophil percentage (EOS%) in patients with acute type...
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BMC
2022-04-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-022-02592-y |
| _version_ | 1818644943530360832 |
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| author | Yue Shao Liu Ye Hao-ming Shi Xin-mei Wang Jun Luo Lu Liu Qing-chen Wu |
| author_facet | Yue Shao Liu Ye Hao-ming Shi Xin-mei Wang Jun Luo Lu Liu Qing-chen Wu |
| author_sort | Yue Shao |
| collection | DOAJ |
| description | Abstract Background Eosinophils are pro-inflammatory cells involved in thrombosis and have been proposed as a prognosis marker in acute ischemic stroke and ST-elevation myocardial Infarction. Here, we sought to clarify the prognostic value of eosinophil percentage (EOS%) in patients with acute type A aortic dissection (AAAD). Methods We examined 183 consecutive AAAD patients. Based on the optimum cut-off value of EOS% determined by X-tile software, patients were classified into the low EOS% (EOS% ≤ 0.1) and high EOS% groups (EOS% > 0.1). We performed multivariate regression analysis and Kaplan–Meier (KM) survival curves to assess the association between EOS% and mortality. Eosinophil accumulation in aortic dissection intraluminal thrombus was confirmed using hematoxylin–eosin (H&E) staining. An external cohort from Medical Information Mart for Intensive Care IV was performed to validate the results. Results Relative to surviving patients, those who died during hospitalization had significantly lower EOS% (p = 0.001) but significantly higher WBC (p = 0.002) and neutrophil (p = 0.001) counts. Multivariate regression analysis identified EOS% as an independent predictor of in-hospital and 1-year mortality. KM curves revealed that 1-year cumulative mortality was significantly higher in the low EOS% group, although it was mainly attributed to the higher 30-day mortality. H&E staining revealed massive infiltration of eosinophils in all 20 thrombus specimens. The external validation confirmed that relative to survivors, patients with in-hospital mortality (p = 0.010) had significantly lower EOS%. Moreover, multivariate regression analyses identified that decreased EOS% was independently significantly associated with in-hospital mortality. Conclusions Low EOS% is significantly related to increased mortality rates in AAAD patients. |
| first_indexed | 2024-12-17T00:22:53Z |
| format | Article |
| id | doaj.art-8d2ca4f1630f47aa916cf03725110082 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-17T00:22:53Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-8d2ca4f1630f47aa916cf037251100822022-12-21T22:10:31ZengBMCBMC Cardiovascular Disorders1471-22612022-04-012211810.1186/s12872-022-02592-yImpacts of eosinophil percentage on prognosis acute type A aortic dissection patientsYue Shao0Liu Ye1Hao-ming Shi2Xin-mei Wang3Jun Luo4Lu Liu5Qing-chen Wu6Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical UniversityThe First Branch, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Pathology, Chongqing Medical UniversityDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical UniversityAbstract Background Eosinophils are pro-inflammatory cells involved in thrombosis and have been proposed as a prognosis marker in acute ischemic stroke and ST-elevation myocardial Infarction. Here, we sought to clarify the prognostic value of eosinophil percentage (EOS%) in patients with acute type A aortic dissection (AAAD). Methods We examined 183 consecutive AAAD patients. Based on the optimum cut-off value of EOS% determined by X-tile software, patients were classified into the low EOS% (EOS% ≤ 0.1) and high EOS% groups (EOS% > 0.1). We performed multivariate regression analysis and Kaplan–Meier (KM) survival curves to assess the association between EOS% and mortality. Eosinophil accumulation in aortic dissection intraluminal thrombus was confirmed using hematoxylin–eosin (H&E) staining. An external cohort from Medical Information Mart for Intensive Care IV was performed to validate the results. Results Relative to surviving patients, those who died during hospitalization had significantly lower EOS% (p = 0.001) but significantly higher WBC (p = 0.002) and neutrophil (p = 0.001) counts. Multivariate regression analysis identified EOS% as an independent predictor of in-hospital and 1-year mortality. KM curves revealed that 1-year cumulative mortality was significantly higher in the low EOS% group, although it was mainly attributed to the higher 30-day mortality. H&E staining revealed massive infiltration of eosinophils in all 20 thrombus specimens. The external validation confirmed that relative to survivors, patients with in-hospital mortality (p = 0.010) had significantly lower EOS%. Moreover, multivariate regression analyses identified that decreased EOS% was independently significantly associated with in-hospital mortality. Conclusions Low EOS% is significantly related to increased mortality rates in AAAD patients.https://doi.org/10.1186/s12872-022-02592-yEosinophilAcute type A aortic dissectionMortalityInflammatory cellsThrombusMedical Information Mart for Intensive Care |
| spellingShingle | Yue Shao Liu Ye Hao-ming Shi Xin-mei Wang Jun Luo Lu Liu Qing-chen Wu Impacts of eosinophil percentage on prognosis acute type A aortic dissection patients BMC Cardiovascular Disorders Eosinophil Acute type A aortic dissection Mortality Inflammatory cells Thrombus Medical Information Mart for Intensive Care |
| title | Impacts of eosinophil percentage on prognosis acute type A aortic dissection patients |
| title_full | Impacts of eosinophil percentage on prognosis acute type A aortic dissection patients |
| title_fullStr | Impacts of eosinophil percentage on prognosis acute type A aortic dissection patients |
| title_full_unstemmed | Impacts of eosinophil percentage on prognosis acute type A aortic dissection patients |
| title_short | Impacts of eosinophil percentage on prognosis acute type A aortic dissection patients |
| title_sort | impacts of eosinophil percentage on prognosis acute type a aortic dissection patients |
| topic | Eosinophil Acute type A aortic dissection Mortality Inflammatory cells Thrombus Medical Information Mart for Intensive Care |
| url | https://doi.org/10.1186/s12872-022-02592-y |
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