The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function
Zebrafish have great potential to contribute to our understanding of behavioural genetics and thus to contribute to our understanding of the aetiology of psychiatric disease. However, progress is dependent upon the rate at which behavioural assays addressing complex behavioural phenotypes are desig...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-04-01
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| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00063/full |
| _version_ | 1798046055399424000 |
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| author | Matthew O Parker Alistair J Brock Robert T Walton Caroline Helen Brennan |
| author_facet | Matthew O Parker Alistair J Brock Robert T Walton Caroline Helen Brennan |
| author_sort | Matthew O Parker |
| collection | DOAJ |
| description | Zebrafish have great potential to contribute to our understanding of behavioural genetics and thus to contribute to our understanding of the aetiology of psychiatric disease. However, progress is dependent upon the rate at which behavioural assays addressing complex behavioural phenotypes are designed, reported and validated. Here we critically review existing behavioural assays with particular focus on the use of adult zebrafish to explore executive processes and phenotypes associated with human psychiatric disease. We outline the case for using zebrafish as models to study impulse control and attention, discussing the validity of applying extant rodent assays to zebrafish and evidence for the conservation of relevant neural circuits. |
| first_indexed | 2024-04-11T23:31:19Z |
| format | Article |
| id | doaj.art-8d2cf2316be94a758737ab56b3458011 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-04-11T23:31:19Z |
| publishDate | 2013-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-8d2cf2316be94a758737ab56b34580112022-12-22T03:57:07ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102013-04-01710.3389/fncir.2013.0006344102The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive functionMatthew O Parker0Alistair J Brock1Robert T Walton2Caroline Helen Brennan3Queen Mary University of LondonQueen Mary University of LondonQueen Mary University of LondonQueen Mary University of LondonZebrafish have great potential to contribute to our understanding of behavioural genetics and thus to contribute to our understanding of the aetiology of psychiatric disease. However, progress is dependent upon the rate at which behavioural assays addressing complex behavioural phenotypes are designed, reported and validated. Here we critically review existing behavioural assays with particular focus on the use of adult zebrafish to explore executive processes and phenotypes associated with human psychiatric disease. We outline the case for using zebrafish as models to study impulse control and attention, discussing the validity of applying extant rodent assays to zebrafish and evidence for the conservation of relevant neural circuits.http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00063/fullAttentionZebrafishimpulsivityneural circuitsPsychiatric disorderbehavioural flexibility |
| spellingShingle | Matthew O Parker Alistair J Brock Robert T Walton Caroline Helen Brennan The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function Frontiers in Neural Circuits Attention Zebrafish impulsivity neural circuits Psychiatric disorder behavioural flexibility |
| title | The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function |
| title_full | The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function |
| title_fullStr | The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function |
| title_full_unstemmed | The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function |
| title_short | The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function |
| title_sort | role of zebrafish danio rerio in dissecting the genetics and neural circuits of executive function |
| topic | Attention Zebrafish impulsivity neural circuits Psychiatric disorder behavioural flexibility |
| url | http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00063/full |
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