Synthesis of bi- and bis-1,2,3-triazoles by copper-catalyzed Huisgen cycloaddition: A family of valuable products by click chemistry
The Cu(I)-catalyzed azide-alkyne cycloaddition reaction, also known as click chemistry, has become a useful tool for the facile formation of 1,2,3-triazoles. Specifically, the utility of this reaction has been demonstrated by the synthesis of structurally diverse bi- and bis-1,2,3-triazoles. The pre...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2015-12-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.11.276 |
| _version_ | 1818641842119376896 |
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| author | Zhan-Jiang Zheng Ding Wang Zheng Xu Li-Wen Xu |
| author_facet | Zhan-Jiang Zheng Ding Wang Zheng Xu Li-Wen Xu |
| author_sort | Zhan-Jiang Zheng |
| collection | DOAJ |
| description | The Cu(I)-catalyzed azide-alkyne cycloaddition reaction, also known as click chemistry, has become a useful tool for the facile formation of 1,2,3-triazoles. Specifically, the utility of this reaction has been demonstrated by the synthesis of structurally diverse bi- and bis-1,2,3-triazoles. The present review focuses on the synthesis of such bi- and bistriazoles and the importance of using copper-promoted click chemistry (CuAAC) for such transformations. In addition, the application of bitriazoles and the related CuAAAC reaction in different fields, including medicinal chemistry, coordination chemistry, biochemistry, and supramolecular chemistry, have been highlighted. |
| first_indexed | 2024-12-16T23:33:35Z |
| format | Article |
| id | doaj.art-8d2ece5a55f84843a3280b3799572703 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-16T23:33:35Z |
| publishDate | 2015-12-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-8d2ece5a55f84843a3280b37995727032022-12-21T22:11:48ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972015-12-011112557257610.3762/bjoc.11.2761860-5397-11-276Synthesis of bi- and bis-1,2,3-triazoles by copper-catalyzed Huisgen cycloaddition: A family of valuable products by click chemistryZhan-Jiang Zheng0Ding Wang1Zheng Xu2Li-Wen Xu3Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, and College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310012, P. R. ChinaKey Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, and College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310012, P. R. ChinaKey Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, and College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310012, P. R. ChinaKey Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, and College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310012, P. R. ChinaThe Cu(I)-catalyzed azide-alkyne cycloaddition reaction, also known as click chemistry, has become a useful tool for the facile formation of 1,2,3-triazoles. Specifically, the utility of this reaction has been demonstrated by the synthesis of structurally diverse bi- and bis-1,2,3-triazoles. The present review focuses on the synthesis of such bi- and bistriazoles and the importance of using copper-promoted click chemistry (CuAAC) for such transformations. In addition, the application of bitriazoles and the related CuAAAC reaction in different fields, including medicinal chemistry, coordination chemistry, biochemistry, and supramolecular chemistry, have been highlighted.https://doi.org/10.3762/bjoc.11.276bistriazolesclick chemistrycycloadditionhomogeneous catalysisoxidative coupling |
| spellingShingle | Zhan-Jiang Zheng Ding Wang Zheng Xu Li-Wen Xu Synthesis of bi- and bis-1,2,3-triazoles by copper-catalyzed Huisgen cycloaddition: A family of valuable products by click chemistry Beilstein Journal of Organic Chemistry bistriazoles click chemistry cycloaddition homogeneous catalysis oxidative coupling |
| title | Synthesis of bi- and bis-1,2,3-triazoles by copper-catalyzed Huisgen cycloaddition: A family of valuable products by click chemistry |
| title_full | Synthesis of bi- and bis-1,2,3-triazoles by copper-catalyzed Huisgen cycloaddition: A family of valuable products by click chemistry |
| title_fullStr | Synthesis of bi- and bis-1,2,3-triazoles by copper-catalyzed Huisgen cycloaddition: A family of valuable products by click chemistry |
| title_full_unstemmed | Synthesis of bi- and bis-1,2,3-triazoles by copper-catalyzed Huisgen cycloaddition: A family of valuable products by click chemistry |
| title_short | Synthesis of bi- and bis-1,2,3-triazoles by copper-catalyzed Huisgen cycloaddition: A family of valuable products by click chemistry |
| title_sort | synthesis of bi and bis 1 2 3 triazoles by copper catalyzed huisgen cycloaddition a family of valuable products by click chemistry |
| topic | bistriazoles click chemistry cycloaddition homogeneous catalysis oxidative coupling |
| url | https://doi.org/10.3762/bjoc.11.276 |
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