Nailfold Videocapillaroscopy in Patients with Rheumatoid Arthritis and Psoriatic Arthropathy on ANTI-TNF-ALPHA Therapy
Videocapillaroscopy is a simple, non-invasive investigation that allows the “in vivo” study of the nailfold capillaries. This method is inexpensive, easily accepted by patients and the results can be easily interpreted. It is mainly used in patients with Raynaud’s phenomenon and systemic sclerosis,...
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MDPI AG
2023-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/12/2079 |
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| author | Daniela Anghel Carmen Adella Sîrbu Oana-Georgiana Petrache Daniela Opriș-Belinski Maria Magdalena Negru Violeta-Claudia Bojincă Cristina Florentina Pleșa Florentina Ioniță Radu |
| author_facet | Daniela Anghel Carmen Adella Sîrbu Oana-Georgiana Petrache Daniela Opriș-Belinski Maria Magdalena Negru Violeta-Claudia Bojincă Cristina Florentina Pleșa Florentina Ioniță Radu |
| author_sort | Daniela Anghel |
| collection | DOAJ |
| description | Videocapillaroscopy is a simple, non-invasive investigation that allows the “in vivo” study of the nailfold capillaries. This method is inexpensive, easily accepted by patients and the results can be easily interpreted. It is mainly used in patients with Raynaud’s phenomenon and systemic sclerosis, but this examination can also be performed on patients who are suspected of having microcirculation alterations, such as rheumatoid arthritis and psoriatic arthritis. It may aid in the diagnosis, evaluation and prognosis of other rheumatic diseases, besides systemic sclerosis. The aim of this study is to identify the nailfold videocapillaroscopic abnormalities in rheumatoid arthritis and psoriatic arthritis patients and analyze the correlation between their evolution and 12 months of anti-TNF-α therapy. The abnormal capillaroscopic findings comprised widened, dilated or giant capillaries and the distortion of the normal nailfold architecture, avascular areas, hemorrhages and neoangiogenesis. Overall, capillary density, dilated capillaries, giant capillaries, elongated capillaries and angiogenesis significantly improved after 12 months. Moreover, no avascular areas were found after 12 months of anti-TNF treatment. |
| first_indexed | 2024-03-11T02:34:52Z |
| format | Article |
| id | doaj.art-8d2f5d12ffc448f595d3b6d38d1f9241 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T02:34:52Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-8d2f5d12ffc448f595d3b6d38d1f92412023-11-18T10:00:47ZengMDPI AGDiagnostics2075-44182023-06-011312207910.3390/diagnostics13122079Nailfold Videocapillaroscopy in Patients with Rheumatoid Arthritis and Psoriatic Arthropathy on ANTI-TNF-ALPHA TherapyDaniela Anghel0Carmen Adella Sîrbu1Oana-Georgiana Petrache2Daniela Opriș-Belinski3Maria Magdalena Negru4Violeta-Claudia Bojincă5Cristina Florentina Pleșa6Florentina Ioniță Radu7Department of Internal Medicine, ‘Dr. Carol Davila’ Central Military Emergency University Hospital, 010242 Bucharest, RomaniaDepartment of Neurology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurology, ‘Dr. Carol Davila’ Central Military Emergency University Hospital, 010242 Bucharest, RomaniaDepartment of Internal Medicine and Rheumatology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Internal Medicine and Rheumatology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Internal Medicine and Rheumatology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Internal Medicine and Gastroenterology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, RomaniaVideocapillaroscopy is a simple, non-invasive investigation that allows the “in vivo” study of the nailfold capillaries. This method is inexpensive, easily accepted by patients and the results can be easily interpreted. It is mainly used in patients with Raynaud’s phenomenon and systemic sclerosis, but this examination can also be performed on patients who are suspected of having microcirculation alterations, such as rheumatoid arthritis and psoriatic arthritis. It may aid in the diagnosis, evaluation and prognosis of other rheumatic diseases, besides systemic sclerosis. The aim of this study is to identify the nailfold videocapillaroscopic abnormalities in rheumatoid arthritis and psoriatic arthritis patients and analyze the correlation between their evolution and 12 months of anti-TNF-α therapy. The abnormal capillaroscopic findings comprised widened, dilated or giant capillaries and the distortion of the normal nailfold architecture, avascular areas, hemorrhages and neoangiogenesis. Overall, capillary density, dilated capillaries, giant capillaries, elongated capillaries and angiogenesis significantly improved after 12 months. Moreover, no avascular areas were found after 12 months of anti-TNF treatment.https://www.mdpi.com/2075-4418/13/12/2079nailfold capillaroscopyrheumatoid arthritispsoriatic arthritisanti-TNF-alpha therapyangiogenesis |
| spellingShingle | Daniela Anghel Carmen Adella Sîrbu Oana-Georgiana Petrache Daniela Opriș-Belinski Maria Magdalena Negru Violeta-Claudia Bojincă Cristina Florentina Pleșa Florentina Ioniță Radu Nailfold Videocapillaroscopy in Patients with Rheumatoid Arthritis and Psoriatic Arthropathy on ANTI-TNF-ALPHA Therapy Diagnostics nailfold capillaroscopy rheumatoid arthritis psoriatic arthritis anti-TNF-alpha therapy angiogenesis |
| title | Nailfold Videocapillaroscopy in Patients with Rheumatoid Arthritis and Psoriatic Arthropathy on ANTI-TNF-ALPHA Therapy |
| title_full | Nailfold Videocapillaroscopy in Patients with Rheumatoid Arthritis and Psoriatic Arthropathy on ANTI-TNF-ALPHA Therapy |
| title_fullStr | Nailfold Videocapillaroscopy in Patients with Rheumatoid Arthritis and Psoriatic Arthropathy on ANTI-TNF-ALPHA Therapy |
| title_full_unstemmed | Nailfold Videocapillaroscopy in Patients with Rheumatoid Arthritis and Psoriatic Arthropathy on ANTI-TNF-ALPHA Therapy |
| title_short | Nailfold Videocapillaroscopy in Patients with Rheumatoid Arthritis and Psoriatic Arthropathy on ANTI-TNF-ALPHA Therapy |
| title_sort | nailfold videocapillaroscopy in patients with rheumatoid arthritis and psoriatic arthropathy on anti tnf alpha therapy |
| topic | nailfold capillaroscopy rheumatoid arthritis psoriatic arthritis anti-TNF-alpha therapy angiogenesis |
| url | https://www.mdpi.com/2075-4418/13/12/2079 |
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