Differential expression of PSMC4, SKP1, and HSPA8 in Parkinson’s disease: insights from a Mexican mestizo population

Differential expression of PSMC4, SKP1, and HSPA8 in Parkinson’s disease: insights from a Mexican mestizo population

Parkinson’s disease (PD) is a complex neurodegenerative condition characterized by alpha-synuclein aggregation and dysfunctional protein degradation pathways. This study investigates the differential gene expression of pivotal components (UBE2K, PSMC4, SKP1, and HSPA8) within these pathways in a Mex...

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Bibliographic Details
Main Authors: Alma C. Salas-Leal, Sergio M. Salas-Pacheco, Erik I. Hernández-Cosaín, Lilia M. Vélez-Vélez, Elizabeth I. Antuna-Salcido, Francisco X. Castellanos-Juárez, Edna M. Méndez-Hernández, Osmel La Llave-León, Gerardo Quiñones-Canales, Oscar Arias-Carrión, Ada A. Sandoval-Carrillo, José M. Salas-Pacheco
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Parkinson’s disease
UBE2K
PSMC4
SKP1
HSPA8
protein degradation systems
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1298560/full

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