The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis
Abstract Among the DNA tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), account for a considerable percentage of virus-associated cancers. Deregulation of transcription factors signaling pathways is one of the most significant oncogenic characteristics of EBV and KSHV. N...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | Infectious Agents and Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13027-020-00317-4 |
| _version_ | 1818061683150553088 |
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| author | J. Charostad M. Nakhaie A. Dehghani E. Faghihloo |
| author_facet | J. Charostad M. Nakhaie A. Dehghani E. Faghihloo |
| author_sort | J. Charostad |
| collection | DOAJ |
| description | Abstract Among the DNA tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), account for a considerable percentage of virus-associated cancers. Deregulation of transcription factors signaling pathways is one of the most significant oncogenic characteristics of EBV and KSHV. NF-κB is a transcription factor that play a remarkable role in oncogenesis because of its function as a master regulator of a spectrum of genes involved in physiological and pathophysiological process. Constitutive activation of NF-κB is a frequent and well-described event in many human malignancies. Compelling evidence represent EBV and KSHV are capable of targeting different components of NF-κB cascade. Here, we summarized recent findings to clarify the precise relationship between dysregulation of NF-κB and EBV and KSHV-related malignancies. This essay also emphasizes on contribution of various viral products in developing cancer through alteration of NF-κB signaling pathway. |
| first_indexed | 2024-12-10T13:52:12Z |
| format | Article |
| id | doaj.art-8d30c16cbb5944578ab439cedbe19cc7 |
| institution | Directory Open Access Journal |
| issn | 1750-9378 |
| language | English |
| last_indexed | 2024-12-10T13:52:12Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Agents and Cancer |
| spelling | doaj.art-8d30c16cbb5944578ab439cedbe19cc72022-12-22T01:46:07ZengBMCInfectious Agents and Cancer1750-93782020-10-0115111210.1186/s13027-020-00317-4The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesisJ. Charostad0M. Nakhaie1A. Dehghani2E. Faghihloo3Department of Medical Virology, School of Medicine, Ahvaz Jundishapur University of Medical SciencesDepartment of Medical Virology, School of Medicine, Ahvaz Jundishapur University of Medical SciencesDepartment of Medical Virology, School of Medicine, Ahvaz Jundishapur University of Medical SciencesDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical SciencesAbstract Among the DNA tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), account for a considerable percentage of virus-associated cancers. Deregulation of transcription factors signaling pathways is one of the most significant oncogenic characteristics of EBV and KSHV. NF-κB is a transcription factor that play a remarkable role in oncogenesis because of its function as a master regulator of a spectrum of genes involved in physiological and pathophysiological process. Constitutive activation of NF-κB is a frequent and well-described event in many human malignancies. Compelling evidence represent EBV and KSHV are capable of targeting different components of NF-κB cascade. Here, we summarized recent findings to clarify the precise relationship between dysregulation of NF-κB and EBV and KSHV-related malignancies. This essay also emphasizes on contribution of various viral products in developing cancer through alteration of NF-κB signaling pathway.http://link.springer.com/article/10.1186/s13027-020-00317-4NF-κBEBVKSHVNeoplasm |
| spellingShingle | J. Charostad M. Nakhaie A. Dehghani E. Faghihloo The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis Infectious Agents and Cancer NF-κB EBV KSHV Neoplasm |
| title | The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis |
| title_full | The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis |
| title_fullStr | The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis |
| title_full_unstemmed | The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis |
| title_short | The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis |
| title_sort | interplay between ebv and kshv viral products and nf κb pathway in oncogenesis |
| topic | NF-κB EBV KSHV Neoplasm |
| url | http://link.springer.com/article/10.1186/s13027-020-00317-4 |
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