Regulation of stress signaling pathways by protein lipoxidation
Enzymatic and non-enzymatic oxidation of unsaturated fatty acids gives rise to reactive species that covalently modify nucleophilic residues within redox sensitive protein sensors in a process called lipoxidation. This triggers adaptive signaling pathways that ultimately lead to increased resistance...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-05-01
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| Series: | Redox Biology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221323171831067X |
| _version_ | 1818172008869920768 |
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| author | Tommi Patinen Simone Adinolfi Carlos Cruz Cortés Jouni Härkönen Ashik Jawahar Deen Anna-Liisa Levonen |
| author_facet | Tommi Patinen Simone Adinolfi Carlos Cruz Cortés Jouni Härkönen Ashik Jawahar Deen Anna-Liisa Levonen |
| author_sort | Tommi Patinen |
| collection | DOAJ |
| description | Enzymatic and non-enzymatic oxidation of unsaturated fatty acids gives rise to reactive species that covalently modify nucleophilic residues within redox sensitive protein sensors in a process called lipoxidation. This triggers adaptive signaling pathways that ultimately lead to increased resistance to stress. In this graphical review, we will provide an overview of pathways affected by protein lipoxidation and the key signaling proteins being altered, focusing on the KEAP1-NRF2 and heat shock response pathways. We review the mechanisms by which lipid peroxidation products can serve as second messengers and evoke cellular responses via covalent modification of key sensors of altered cellular environment, ultimately leading to adaptation to stress. Keywords: Redox regulation, Protein lipoxidation, Stress response, NRF2, KEAP1, HSF1, Heat shock proteins, Cysteine modification |
| first_indexed | 2024-12-11T19:05:47Z |
| format | Article |
| id | doaj.art-8d33041e0f964b5d8217790667fc8742 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-12-11T19:05:47Z |
| publishDate | 2019-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-8d33041e0f964b5d8217790667fc87422022-12-22T00:53:54ZengElsevierRedox Biology2213-23172019-05-0123Regulation of stress signaling pathways by protein lipoxidationTommi Patinen0Simone Adinolfi1Carlos Cruz Cortés2Jouni Härkönen3Ashik Jawahar Deen4Anna-Liisa Levonen5A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Neulaniementie 2, Kuopio FIN-70211, FinlandA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Neulaniementie 2, Kuopio FIN-70211, FinlandA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Neulaniementie 2, Kuopio FIN-70211, Finland; Department of Biochemistry, Center for Research and Advanced Studies of the National Polytechnic Institute, CINVESTAV-IPN, Mexico City MX-07360, MexicoA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Neulaniementie 2, Kuopio FIN-70211, FinlandA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Neulaniementie 2, Kuopio FIN-70211, FinlandA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Neulaniementie 2, Kuopio FIN-70211, Finland; Corresponding author.Enzymatic and non-enzymatic oxidation of unsaturated fatty acids gives rise to reactive species that covalently modify nucleophilic residues within redox sensitive protein sensors in a process called lipoxidation. This triggers adaptive signaling pathways that ultimately lead to increased resistance to stress. In this graphical review, we will provide an overview of pathways affected by protein lipoxidation and the key signaling proteins being altered, focusing on the KEAP1-NRF2 and heat shock response pathways. We review the mechanisms by which lipid peroxidation products can serve as second messengers and evoke cellular responses via covalent modification of key sensors of altered cellular environment, ultimately leading to adaptation to stress. Keywords: Redox regulation, Protein lipoxidation, Stress response, NRF2, KEAP1, HSF1, Heat shock proteins, Cysteine modificationhttp://www.sciencedirect.com/science/article/pii/S221323171831067X |
| spellingShingle | Tommi Patinen Simone Adinolfi Carlos Cruz Cortés Jouni Härkönen Ashik Jawahar Deen Anna-Liisa Levonen Regulation of stress signaling pathways by protein lipoxidation Redox Biology |
| title | Regulation of stress signaling pathways by protein lipoxidation |
| title_full | Regulation of stress signaling pathways by protein lipoxidation |
| title_fullStr | Regulation of stress signaling pathways by protein lipoxidation |
| title_full_unstemmed | Regulation of stress signaling pathways by protein lipoxidation |
| title_short | Regulation of stress signaling pathways by protein lipoxidation |
| title_sort | regulation of stress signaling pathways by protein lipoxidation |
| url | http://www.sciencedirect.com/science/article/pii/S221323171831067X |
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