Immature Platelet Fraction and Thrombin Generation: Preeclampsia Biomarkers
Abstract Preeclampsia, a human pregnancy syndrome, is characterized by elevated blood pressure and proteinuria after the 20th week of gestation. Its etiology remains unknown, and its pathophysiological mechanisms are related to placental hypoperfusion, endothelial dysfunction, inflammation, and coag...
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| Format: | Article |
| Language: | English |
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2022-10-01
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| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032022000800771&tlng=en |
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| author | Daniela Moraes Camila Milioni Carolina Friske Vieira Eveline Avila Parera Bárbara Dewes Silva Miriam Viviane Baron Bartira Ercília Pinheiro da Costa Carlos Eduardo Poli-de-Figueiredo |
| author_facet | Daniela Moraes Camila Milioni Carolina Friske Vieira Eveline Avila Parera Bárbara Dewes Silva Miriam Viviane Baron Bartira Ercília Pinheiro da Costa Carlos Eduardo Poli-de-Figueiredo |
| author_sort | Daniela Moraes |
| collection | DOAJ |
| description | Abstract Preeclampsia, a human pregnancy syndrome, is characterized by elevated blood pressure and proteinuria after the 20th week of gestation. Its etiology remains unknown, and its pathophysiological mechanisms are related to placental hypoperfusion, endothelial dysfunction, inflammation, and coagulation cascade activation. Recently, the role of the complement system has been considered. This syndrome is one of the main causes of maternal and fetal mortality and morbidity. This article discusses the hypothesis of preeclampsia being triggered by the occurrence of inadequate implantation of the syncytiotrophoblast, associated with bleeding during the first stage of pregnancy and with augmented thrombin generation. Thrombin activates platelets, increasing the release of antiangiogenic factors and activating the complement system, inducing the membrane attack complex (C5b9). Immature platelet fraction and thrombin generation may be possible blood biomarkers to help the early diagnosis of preeclampsia. |
| first_indexed | 2024-04-12T13:45:50Z |
| format | Article |
| id | doaj.art-8d35420cab1446b08240fb34009f47df |
| institution | Directory Open Access Journal |
| issn | 0100-7203 |
| language | English |
| last_indexed | 2024-04-12T13:45:50Z |
| publishDate | 2022-10-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj.art-8d35420cab1446b08240fb34009f47df2022-12-22T03:30:42ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032022-10-0144877177510.1055/s-0042-1743100Immature Platelet Fraction and Thrombin Generation: Preeclampsia BiomarkersDaniela Moraeshttps://orcid.org/0000-0001-7835-3269Camila Milionihttps://orcid.org/0000-0002-7576-3016Carolina Friske Vieirahttps://orcid.org/0000-0002-8892-9994Eveline Avila Parerahttps://orcid.org/0000-0003-4325-3895Bárbara Dewes Silvahttps://orcid.org/0000-0002-9657-3879Miriam Viviane Baronhttps://orcid.org/0000-0002-3673-9750Bartira Ercília Pinheiro da Costahttps://orcid.org/0000-0001-8015-3952Carlos Eduardo Poli-de-Figueiredohttps://orcid.org/0000-0002-7333-8884Abstract Preeclampsia, a human pregnancy syndrome, is characterized by elevated blood pressure and proteinuria after the 20th week of gestation. Its etiology remains unknown, and its pathophysiological mechanisms are related to placental hypoperfusion, endothelial dysfunction, inflammation, and coagulation cascade activation. Recently, the role of the complement system has been considered. This syndrome is one of the main causes of maternal and fetal mortality and morbidity. This article discusses the hypothesis of preeclampsia being triggered by the occurrence of inadequate implantation of the syncytiotrophoblast, associated with bleeding during the first stage of pregnancy and with augmented thrombin generation. Thrombin activates platelets, increasing the release of antiangiogenic factors and activating the complement system, inducing the membrane attack complex (C5b9). Immature platelet fraction and thrombin generation may be possible blood biomarkers to help the early diagnosis of preeclampsia.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032022000800771&tlng=enplateletsplatelet activationhypertension pregnancy-inducedblood coagulationcomplement system proteins |
| spellingShingle | Daniela Moraes Camila Milioni Carolina Friske Vieira Eveline Avila Parera Bárbara Dewes Silva Miriam Viviane Baron Bartira Ercília Pinheiro da Costa Carlos Eduardo Poli-de-Figueiredo Immature Platelet Fraction and Thrombin Generation: Preeclampsia Biomarkers Revista Brasileira de Ginecologia e Obstetrícia platelets platelet activation hypertension pregnancy-induced blood coagulation complement system proteins |
| title | Immature Platelet Fraction and Thrombin Generation: Preeclampsia Biomarkers |
| title_full | Immature Platelet Fraction and Thrombin Generation: Preeclampsia Biomarkers |
| title_fullStr | Immature Platelet Fraction and Thrombin Generation: Preeclampsia Biomarkers |
| title_full_unstemmed | Immature Platelet Fraction and Thrombin Generation: Preeclampsia Biomarkers |
| title_short | Immature Platelet Fraction and Thrombin Generation: Preeclampsia Biomarkers |
| title_sort | immature platelet fraction and thrombin generation preeclampsia biomarkers |
| topic | platelets platelet activation hypertension pregnancy-induced blood coagulation complement system proteins |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032022000800771&tlng=en |
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