Therapeutic Potential of Gut Microbiota and Its Metabolite Short-Chain Fatty Acids in Neonatal Necrotizing Enterocolitis
Short chain fatty acids (SCFAs), the principle end-products produced by the anaerobic gut microbial fermentation of complex carbohydrates (CHO) in the colon perform beneficial roles in metabolic health. Butyrate, acetate and propionate are the main SCFA metabolites, which maintain gut homeostasis an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/2/561 |
| _version_ | 1797619775947407360 |
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| author | Naser A. Alsharairi |
| author_facet | Naser A. Alsharairi |
| author_sort | Naser A. Alsharairi |
| collection | DOAJ |
| description | Short chain fatty acids (SCFAs), the principle end-products produced by the anaerobic gut microbial fermentation of complex carbohydrates (CHO) in the colon perform beneficial roles in metabolic health. Butyrate, acetate and propionate are the main SCFA metabolites, which maintain gut homeostasis and host immune responses, enhance gut barrier integrity and reduce gut inflammation via a range of epigenetic modifications in DNA/histone methylation underlying these effects. The infant gut microbiota composition is characterized by higher abundances of SCFA-producing bacteria. A large number of in vitro/vivo studies have demonstrated the therapeutic implications of SCFA-producing bacteria in infant inflammatory diseases, such as obesity and asthma, but the application of gut microbiota and its metabolite SCFAs to necrotizing enterocolitis (NEC), an acute inflammatory necrosis of the distal small intestine/colon affecting premature newborns, is scarce. Indeed, the beneficial health effects attributed to SCFAs and SCFA-producing bacteria in neonatal NEC are still to be understood. Thus, this literature review aims to summarize the available evidence on the therapeutic potential of gut microbiota and its metabolite SCFAs in neonatal NEC using the PubMed/MEDLINE database. |
| first_indexed | 2024-03-11T08:32:37Z |
| format | Article |
| id | doaj.art-8d37239c0a994302ab6ecd6aded83c46 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T08:32:37Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-8d37239c0a994302ab6ecd6aded83c462023-11-16T21:42:57ZengMDPI AGLife2075-17292023-02-0113256110.3390/life13020561Therapeutic Potential of Gut Microbiota and Its Metabolite Short-Chain Fatty Acids in Neonatal Necrotizing EnterocolitisNaser A. Alsharairi0Heart, Mind and Body Research Group, Griffith University, Gold Coast, QLD 4222, AustraliaShort chain fatty acids (SCFAs), the principle end-products produced by the anaerobic gut microbial fermentation of complex carbohydrates (CHO) in the colon perform beneficial roles in metabolic health. Butyrate, acetate and propionate are the main SCFA metabolites, which maintain gut homeostasis and host immune responses, enhance gut barrier integrity and reduce gut inflammation via a range of epigenetic modifications in DNA/histone methylation underlying these effects. The infant gut microbiota composition is characterized by higher abundances of SCFA-producing bacteria. A large number of in vitro/vivo studies have demonstrated the therapeutic implications of SCFA-producing bacteria in infant inflammatory diseases, such as obesity and asthma, but the application of gut microbiota and its metabolite SCFAs to necrotizing enterocolitis (NEC), an acute inflammatory necrosis of the distal small intestine/colon affecting premature newborns, is scarce. Indeed, the beneficial health effects attributed to SCFAs and SCFA-producing bacteria in neonatal NEC are still to be understood. Thus, this literature review aims to summarize the available evidence on the therapeutic potential of gut microbiota and its metabolite SCFAs in neonatal NEC using the PubMed/MEDLINE database.https://www.mdpi.com/2075-1729/13/2/561necrotizing enterocolitispremature infantshort-chain fatty acidsmetabolitesgut microbiota |
| spellingShingle | Naser A. Alsharairi Therapeutic Potential of Gut Microbiota and Its Metabolite Short-Chain Fatty Acids in Neonatal Necrotizing Enterocolitis Life necrotizing enterocolitis premature infant short-chain fatty acids metabolites gut microbiota |
| title | Therapeutic Potential of Gut Microbiota and Its Metabolite Short-Chain Fatty Acids in Neonatal Necrotizing Enterocolitis |
| title_full | Therapeutic Potential of Gut Microbiota and Its Metabolite Short-Chain Fatty Acids in Neonatal Necrotizing Enterocolitis |
| title_fullStr | Therapeutic Potential of Gut Microbiota and Its Metabolite Short-Chain Fatty Acids in Neonatal Necrotizing Enterocolitis |
| title_full_unstemmed | Therapeutic Potential of Gut Microbiota and Its Metabolite Short-Chain Fatty Acids in Neonatal Necrotizing Enterocolitis |
| title_short | Therapeutic Potential of Gut Microbiota and Its Metabolite Short-Chain Fatty Acids in Neonatal Necrotizing Enterocolitis |
| title_sort | therapeutic potential of gut microbiota and its metabolite short chain fatty acids in neonatal necrotizing enterocolitis |
| topic | necrotizing enterocolitis premature infant short-chain fatty acids metabolites gut microbiota |
| url | https://www.mdpi.com/2075-1729/13/2/561 |
| work_keys_str_mv | AT naseraalsharairi therapeuticpotentialofgutmicrobiotaanditsmetaboliteshortchainfattyacidsinneonatalnecrotizingenterocolitis |