Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma
The airway epithelium is the primary site where inhaled and resident microbiota interacts between themselves and the host, potentially playing an important role on allergic asthma development and pathophysiology. With the advent of culture independent molecular techniques and high throughput technol...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Allergy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/falgy.2020.617240/full |
| _version_ | 1811328278334537728 |
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| author | Panagiota Tzani-Tzanopoulou Dimitrios Skliros Spyridon Megremis Paraskevi Xepapadaki Evangelos Andreakos Nina Chanishvili Emmanouil Flemetakis Grigoris Kaltsas Styliani Taka Evangelia Lebessi Anastassios Doudoulakakis Nikolaos G. Papadopoulos Nikolaos G. Papadopoulos |
| author_facet | Panagiota Tzani-Tzanopoulou Dimitrios Skliros Spyridon Megremis Paraskevi Xepapadaki Evangelos Andreakos Nina Chanishvili Emmanouil Flemetakis Grigoris Kaltsas Styliani Taka Evangelia Lebessi Anastassios Doudoulakakis Nikolaos G. Papadopoulos Nikolaos G. Papadopoulos |
| author_sort | Panagiota Tzani-Tzanopoulou |
| collection | DOAJ |
| description | The airway epithelium is the primary site where inhaled and resident microbiota interacts between themselves and the host, potentially playing an important role on allergic asthma development and pathophysiology. With the advent of culture independent molecular techniques and high throughput technologies, the complex composition and diversity of bacterial communities of the airways has been well-documented and the notion of the lungs' sterility definitively rejected. Recent studies indicate that the microbial composition of the asthmatic airways across the spectrum of disease severity, differ significantly compared with healthy individuals. In parallel, a growing body of evidence suggests that bacterial viruses (bacteriophages or simply phages), regulating bacterial populations, are present in almost every niche of the human body and can also interact directly with the eukaryotic cells. The triptych of airway epithelial cells, bacterial symbionts and resident phages should be considered as a functional and interdependent unit with direct implications on the respiratory and overall homeostasis. While the role of epithelial cells in asthma pathophysiology is well-established, the tripartite interactions between epithelial cells, bacteria and phages should be scrutinized, both to better understand asthma as a system disorder and to explore potential interventions. |
| first_indexed | 2024-04-13T15:23:29Z |
| format | Article |
| id | doaj.art-8d37e1dfe8af4bfd8600b74a939e2b59 |
| institution | Directory Open Access Journal |
| issn | 2673-6101 |
| language | English |
| last_indexed | 2024-04-13T15:23:29Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Allergy |
| spelling | doaj.art-8d37e1dfe8af4bfd8600b74a939e2b592022-12-22T02:41:35ZengFrontiers Media S.A.Frontiers in Allergy2673-61012021-01-01110.3389/falgy.2020.617240617240Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of AsthmaPanagiota Tzani-Tzanopoulou0Dimitrios Skliros1Spyridon Megremis2Paraskevi Xepapadaki3Evangelos Andreakos4Nina Chanishvili5Emmanouil Flemetakis6Grigoris Kaltsas7Styliani Taka8Evangelia Lebessi9Anastassios Doudoulakakis10Nikolaos G. Papadopoulos11Nikolaos G. Papadopoulos12Allergy and Clinical Immunology Unit, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, GreeceLaboratory of Molecular Biology, Department of Biotechnology, School of Food, Biotechnology and Development, Agricultural University of Athens, Athens, GreeceDivision of Evolution and Genomic Sciences, University of Manchester, Manchester, United KingdomAllergy and Clinical Immunology Unit, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, GreeceCenter for Clinical, Experimental Surgery and Translational Research of the Biomedical Research Foundation of the Academy of Athens, Athens, GreeceLaboratory for Genetics of Microorganisms and Bacteriophages, Eliava Institute of Bacteriophage, Microbiology & Virology, Tbilisi, GeorgiaLaboratory of Molecular Biology, Department of Biotechnology, School of Food, Biotechnology and Development, Agricultural University of Athens, Athens, GreeceDepartment of Electrical and Electronic Engineering, University of West Attica, Athens, GreeceAllergy and Clinical Immunology Unit, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, GreeceDepartment of Microbiology, P. & A. Kyriakou Children's Hospital, Athens, GreeceDepartment of Microbiology, P. & A. Kyriakou Children's Hospital, Athens, GreeceAllergy and Clinical Immunology Unit, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, GreeceDivision of Evolution and Genomic Sciences, University of Manchester, Manchester, United KingdomThe airway epithelium is the primary site where inhaled and resident microbiota interacts between themselves and the host, potentially playing an important role on allergic asthma development and pathophysiology. With the advent of culture independent molecular techniques and high throughput technologies, the complex composition and diversity of bacterial communities of the airways has been well-documented and the notion of the lungs' sterility definitively rejected. Recent studies indicate that the microbial composition of the asthmatic airways across the spectrum of disease severity, differ significantly compared with healthy individuals. In parallel, a growing body of evidence suggests that bacterial viruses (bacteriophages or simply phages), regulating bacterial populations, are present in almost every niche of the human body and can also interact directly with the eukaryotic cells. The triptych of airway epithelial cells, bacterial symbionts and resident phages should be considered as a functional and interdependent unit with direct implications on the respiratory and overall homeostasis. While the role of epithelial cells in asthma pathophysiology is well-established, the tripartite interactions between epithelial cells, bacteria and phages should be scrutinized, both to better understand asthma as a system disorder and to explore potential interventions.https://www.frontiersin.org/articles/10.3389/falgy.2020.617240/fullbacteriaasthmabacteriophagesairway mucosatripartite symbiosis |
| spellingShingle | Panagiota Tzani-Tzanopoulou Dimitrios Skliros Spyridon Megremis Paraskevi Xepapadaki Evangelos Andreakos Nina Chanishvili Emmanouil Flemetakis Grigoris Kaltsas Styliani Taka Evangelia Lebessi Anastassios Doudoulakakis Nikolaos G. Papadopoulos Nikolaos G. Papadopoulos Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma Frontiers in Allergy bacteria asthma bacteriophages airway mucosa tripartite symbiosis |
| title | Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma |
| title_full | Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma |
| title_fullStr | Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma |
| title_full_unstemmed | Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma |
| title_short | Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma |
| title_sort | interactions of bacteriophages and bacteria at the airway mucosa new insights into the pathophysiology of asthma |
| topic | bacteria asthma bacteriophages airway mucosa tripartite symbiosis |
| url | https://www.frontiersin.org/articles/10.3389/falgy.2020.617240/full |
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