Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways

Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways

Summary: Background: Cataracts are the main cause of reversible blindness worldwide. The ageing of the lens caused by ultraviolet B (UVB) radiation is mostly related to oxidative stress (OS). Little is known about whether OS induced by UVB enhances the sensitivity of lens epithelial cells to ferrop...

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Bibliographic Details
Main Authors: Yu Mi, Chaoqun Wei, Liyao Sun, Huirui Liu, Jiayue Zhang, Jialin Luo, Xiaohan Yu, Jie He, Hongyan Ge, Ping Liu
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Ultraviolet B
Ferroptosis
Cataract
Melatonin
SIRT6
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222014378

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