Designing Gold Nanoparticles for Precise Glioma Treatment: Challenges and Alternatives
Glioblastoma multiforme (GBM) is a glioma and the most aggressive type of brain tumor with a dismal average survival time, despite the standard of care. One promising alternative therapy is boron neutron capture therapy (BNCT), which is a noninvasive therapy for treating locally invasive malignant t...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-03-01
|
| Series: | Materials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1996-1944/17/5/1153 |
| _version_ | 1797264233387261952 |
|---|---|
| author | Cedric Lansangan Menka Khoobchandani Ruchit Jain Serge Rudensky Christopher C. Perry Rameshwar Patil |
| author_facet | Cedric Lansangan Menka Khoobchandani Ruchit Jain Serge Rudensky Christopher C. Perry Rameshwar Patil |
| author_sort | Cedric Lansangan |
| collection | DOAJ |
| description | Glioblastoma multiforme (GBM) is a glioma and the most aggressive type of brain tumor with a dismal average survival time, despite the standard of care. One promising alternative therapy is boron neutron capture therapy (BNCT), which is a noninvasive therapy for treating locally invasive malignant tumors, such as glioma. BNCT involves boron-10 isotope capturing neutrons to form boron-11, which then releases radiation directly into tumor cells with minimal damage to healthy tissues. This therapy lacks clinically approved targeted blood–brain-barrier-permeating delivery vehicles for the central nervous system (CNS) entry of therapeutic boron-10. Gold nanoparticles (GNPs) are selective and effective drug-delivery vehicles because of their desirable properties, facile synthesis, and biocompatibility. This review discusses biomedical/therapeutic applications of GNPs as a drug delivery vehicle, with an emphasis on their potential for carrying therapeutic drugs, imaging agents, and GBM-targeting antibodies/peptides for treating glioma. The constraints of GNP therapeutic efficacy and biosafety are discussed. |
| first_indexed | 2024-04-25T00:25:39Z |
| format | Article |
| id | doaj.art-8d3b41b6d77b4384af9aa25b272608de |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-04-25T00:25:39Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-8d3b41b6d77b4384af9aa25b272608de2024-03-12T16:49:27ZengMDPI AGMaterials1996-19442024-03-01175115310.3390/ma17051153Designing Gold Nanoparticles for Precise Glioma Treatment: Challenges and AlternativesCedric Lansangan0Menka Khoobchandani1Ruchit Jain2Serge Rudensky3Christopher C. Perry4Rameshwar Patil5Division of Cancer Science, Departments of Basic Sciences and Neurosurgery, School of Medicine, Loma Linda University (LLU), 11175 Campus St., Loma Linda, CA 92350, USADivision of Cancer Science, Departments of Basic Sciences and Neurosurgery, School of Medicine, Loma Linda University (LLU), 11175 Campus St., Loma Linda, CA 92350, USADepartment of Surgery, Government Medical College, Miraj 416410, IndiaDivision of Cancer Science, Departments of Basic Sciences and Neurosurgery, School of Medicine, Loma Linda University (LLU), 11175 Campus St., Loma Linda, CA 92350, USADivision of Biochemistry, Department of Basic Sciences, School of Medicine, Loma Linda University (LLU), 11175 Campus St., Loma Linda, CA 92350, USADivision of Cancer Science, Departments of Basic Sciences and Neurosurgery, School of Medicine, Loma Linda University (LLU), 11175 Campus St., Loma Linda, CA 92350, USAGlioblastoma multiforme (GBM) is a glioma and the most aggressive type of brain tumor with a dismal average survival time, despite the standard of care. One promising alternative therapy is boron neutron capture therapy (BNCT), which is a noninvasive therapy for treating locally invasive malignant tumors, such as glioma. BNCT involves boron-10 isotope capturing neutrons to form boron-11, which then releases radiation directly into tumor cells with minimal damage to healthy tissues. This therapy lacks clinically approved targeted blood–brain-barrier-permeating delivery vehicles for the central nervous system (CNS) entry of therapeutic boron-10. Gold nanoparticles (GNPs) are selective and effective drug-delivery vehicles because of their desirable properties, facile synthesis, and biocompatibility. This review discusses biomedical/therapeutic applications of GNPs as a drug delivery vehicle, with an emphasis on their potential for carrying therapeutic drugs, imaging agents, and GBM-targeting antibodies/peptides for treating glioma. The constraints of GNP therapeutic efficacy and biosafety are discussed.https://www.mdpi.com/1996-1944/17/5/1153gold nanoparticlenanomedicineglioblastoma multiformeblood–brain barrierbrain tumor treatmenttargeted drug delivery |
| spellingShingle | Cedric Lansangan Menka Khoobchandani Ruchit Jain Serge Rudensky Christopher C. Perry Rameshwar Patil Designing Gold Nanoparticles for Precise Glioma Treatment: Challenges and Alternatives Materials gold nanoparticle nanomedicine glioblastoma multiforme blood–brain barrier brain tumor treatment targeted drug delivery |
| title | Designing Gold Nanoparticles for Precise Glioma Treatment: Challenges and Alternatives |
| title_full | Designing Gold Nanoparticles for Precise Glioma Treatment: Challenges and Alternatives |
| title_fullStr | Designing Gold Nanoparticles for Precise Glioma Treatment: Challenges and Alternatives |
| title_full_unstemmed | Designing Gold Nanoparticles for Precise Glioma Treatment: Challenges and Alternatives |
| title_short | Designing Gold Nanoparticles for Precise Glioma Treatment: Challenges and Alternatives |
| title_sort | designing gold nanoparticles for precise glioma treatment challenges and alternatives |
| topic | gold nanoparticle nanomedicine glioblastoma multiforme blood–brain barrier brain tumor treatment targeted drug delivery |
| url | https://www.mdpi.com/1996-1944/17/5/1153 |
| work_keys_str_mv | AT cedriclansangan designinggoldnanoparticlesforprecisegliomatreatmentchallengesandalternatives AT menkakhoobchandani designinggoldnanoparticlesforprecisegliomatreatmentchallengesandalternatives AT ruchitjain designinggoldnanoparticlesforprecisegliomatreatmentchallengesandalternatives AT sergerudensky designinggoldnanoparticlesforprecisegliomatreatmentchallengesandalternatives AT christophercperry designinggoldnanoparticlesforprecisegliomatreatmentchallengesandalternatives AT rameshwarpatil designinggoldnanoparticlesforprecisegliomatreatmentchallengesandalternatives |