Stem cell-based therapy for human diseases
Abstract Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated. Stem cell-based therapy, including human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells (MSCs), has recently emerged as a key pl...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2022-08-01
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| Series: | Signal Transduction and Targeted Therapy |
| Online Access: | https://doi.org/10.1038/s41392-022-01134-4 |
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| author | Duc M. Hoang Phuong T. Pham Trung Q. Bach Anh T. L. Ngo Quyen T. Nguyen Trang T. K. Phan Giang H. Nguyen Phuong T. T. Le Van T. Hoang Nicholas R. Forsyth Michael Heke Liem Thanh Nguyen |
| author_facet | Duc M. Hoang Phuong T. Pham Trung Q. Bach Anh T. L. Ngo Quyen T. Nguyen Trang T. K. Phan Giang H. Nguyen Phuong T. T. Le Van T. Hoang Nicholas R. Forsyth Michael Heke Liem Thanh Nguyen |
| author_sort | Duc M. Hoang |
| collection | DOAJ |
| description | Abstract Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated. Stem cell-based therapy, including human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells (MSCs), has recently emerged as a key player in regenerative medicine. hPSCs are defined as self-renewable cell types conferring the ability to differentiate into various cellular phenotypes of the human body, including three germ layers. MSCs are multipotent progenitor cells possessing self-renewal ability (limited in vitro) and differentiation potential into mesenchymal lineages, according to the International Society for Cell and Gene Therapy (ISCT). This review provides an update on recent clinical applications using either hPSCs or MSCs derived from bone marrow (BM), adipose tissue (AT), or the umbilical cord (UC) for the treatment of human diseases, including neurological disorders, pulmonary dysfunctions, metabolic/endocrine-related diseases, reproductive disorders, skin burns, and cardiovascular conditions. Moreover, we discuss our own clinical trial experiences on targeted therapies using MSCs in a clinical setting, and we propose and discuss the MSC tissue origin concept and how MSC origin may contribute to the role of MSCs in downstream applications, with the ultimate objective of facilitating translational research in regenerative medicine into clinical applications. The mechanisms discussed here support the proposed hypothesis that BM-MSCs are potentially good candidates for brain and spinal cord injury treatment, AT-MSCs are potentially good candidates for reproductive disorder treatment and skin regeneration, and UC-MSCs are potentially good candidates for pulmonary disease and acute respiratory distress syndrome treatment. |
| first_indexed | 2024-04-11T21:35:00Z |
| format | Article |
| id | doaj.art-8d3dec7aa7784dfea55abcf9df38ca3e |
| institution | Directory Open Access Journal |
| issn | 2059-3635 |
| language | English |
| last_indexed | 2024-04-11T21:35:00Z |
| publishDate | 2022-08-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Signal Transduction and Targeted Therapy |
| spelling | doaj.art-8d3dec7aa7784dfea55abcf9df38ca3e2022-12-22T04:01:47ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352022-08-017114110.1038/s41392-022-01134-4Stem cell-based therapy for human diseasesDuc M. Hoang0Phuong T. Pham1Trung Q. Bach2Anh T. L. Ngo3Quyen T. Nguyen4Trang T. K. Phan5Giang H. Nguyen6Phuong T. T. Le7Van T. Hoang8Nicholas R. Forsyth9Michael Heke10Liem Thanh Nguyen11Department of Research and Development, Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare SystemDepartment of Cellular Therapy, Vinmec High-Tech Center, Vinmec Healthcare SystemDepartment of Research and Development, Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare SystemDepartment of Cellular Therapy, Vinmec High-Tech Center, Vinmec Healthcare SystemDepartment of Research and Development, Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare SystemDepartment of Research and Development, Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare SystemDepartment of Research and Development, Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare SystemDepartment of Research and Development, Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare SystemDepartment of Research and Development, Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare SystemInstitute for Science & Technology in Medicine, Keele UniversityDepartment of Biology, Stanford UniversityDepartment of Research and Development, Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare SystemAbstract Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated. Stem cell-based therapy, including human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells (MSCs), has recently emerged as a key player in regenerative medicine. hPSCs are defined as self-renewable cell types conferring the ability to differentiate into various cellular phenotypes of the human body, including three germ layers. MSCs are multipotent progenitor cells possessing self-renewal ability (limited in vitro) and differentiation potential into mesenchymal lineages, according to the International Society for Cell and Gene Therapy (ISCT). This review provides an update on recent clinical applications using either hPSCs or MSCs derived from bone marrow (BM), adipose tissue (AT), or the umbilical cord (UC) for the treatment of human diseases, including neurological disorders, pulmonary dysfunctions, metabolic/endocrine-related diseases, reproductive disorders, skin burns, and cardiovascular conditions. Moreover, we discuss our own clinical trial experiences on targeted therapies using MSCs in a clinical setting, and we propose and discuss the MSC tissue origin concept and how MSC origin may contribute to the role of MSCs in downstream applications, with the ultimate objective of facilitating translational research in regenerative medicine into clinical applications. The mechanisms discussed here support the proposed hypothesis that BM-MSCs are potentially good candidates for brain and spinal cord injury treatment, AT-MSCs are potentially good candidates for reproductive disorder treatment and skin regeneration, and UC-MSCs are potentially good candidates for pulmonary disease and acute respiratory distress syndrome treatment.https://doi.org/10.1038/s41392-022-01134-4 |
| spellingShingle | Duc M. Hoang Phuong T. Pham Trung Q. Bach Anh T. L. Ngo Quyen T. Nguyen Trang T. K. Phan Giang H. Nguyen Phuong T. T. Le Van T. Hoang Nicholas R. Forsyth Michael Heke Liem Thanh Nguyen Stem cell-based therapy for human diseases Signal Transduction and Targeted Therapy |
| title | Stem cell-based therapy for human diseases |
| title_full | Stem cell-based therapy for human diseases |
| title_fullStr | Stem cell-based therapy for human diseases |
| title_full_unstemmed | Stem cell-based therapy for human diseases |
| title_short | Stem cell-based therapy for human diseases |
| title_sort | stem cell based therapy for human diseases |
| url | https://doi.org/10.1038/s41392-022-01134-4 |
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