Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane
An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL)...
| Autores principales: | , , , |
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| Formato: | Artículo |
| Lenguaje: | English |
| Publicado: |
Serbian Chemical Society
2002-01-01
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| Colección: | Journal of the Serbian Chemical Society |
| Materias: | |
| Acceso en línea: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2002/0352-51390207465O.pdf |
| Sumario: | An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL). |
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| ISSN: | 0352-5139 1820-7421 |