Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane
An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL)...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2002-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2002/0352-51390207465O.pdf |
| _version_ | 1818945267680935936 |
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| author | Opsenica Dejan M. Pocsfalvi Gabriella Milhous Wilburk K. Šolaja Bogdan A. |
| author_facet | Opsenica Dejan M. Pocsfalvi Gabriella Milhous Wilburk K. Šolaja Bogdan A. |
| author_sort | Opsenica Dejan M. |
| collection | DOAJ |
| description | An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL). |
| first_indexed | 2024-12-20T07:56:24Z |
| format | Article |
| id | doaj.art-8d3f7c6121a242d2912f97d80b7d531d |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-12-20T07:56:24Z |
| publishDate | 2002-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-8d3f7c6121a242d2912f97d80b7d531d2022-12-21T19:47:41ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212002-01-0167746547110.2298/JSC0207465O0352-51390207465OAntimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxaneOpsenica Dejan M.0Pocsfalvi Gabriella1Milhous Wilburk K.2Šolaja Bogdan A.3Institute of Chemistry, Technology and Metallurgy, BelgradeIstituto di Scienze dell’Alimentazione - Centro di Spettrometria di Massa Proteomica e Biomoleculare, Consiglio Nazionale delle Ricerche, Avellino, ItalyDivision of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC, USAFaculty of Chemistry, BelgradeAn intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL).http://www.doiserbia.nb.rs/img/doi/0352-5139/2002/0352-51390207465O.pdftetraoxanemalariaperoxidesteroidintramolecular |
| spellingShingle | Opsenica Dejan M. Pocsfalvi Gabriella Milhous Wilburk K. Šolaja Bogdan A. Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane Journal of the Serbian Chemical Society tetraoxane malaria peroxide steroid intramolecular |
| title | Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane |
| title_full | Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane |
| title_fullStr | Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane |
| title_full_unstemmed | Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane |
| title_short | Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane |
| title_sort | antimalarial peroxides the first intramolecular 1 2 4 5 tetraoxane |
| topic | tetraoxane malaria peroxide steroid intramolecular |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2002/0352-51390207465O.pdf |
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