Association between maternal coronavirus disease 2019 and transient tachypnea of the newborn: a single-center study
Background Limited clinical reports have investigated the effects of maternal coronavirus disease 2019 (COVID-19) on fetuses and neonates. Purpose This retrospective study aimed to assess the impact of maternal COVID-19 on neonates during the perinatal period, including neonatal clinical outcomes, v...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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The Korean Pediatric Society
2023-11-01
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| Series: | Clinical and Experimental Pediatrics |
| Subjects: | |
| Online Access: | http://www.e-cep.org/upload/pdf/cep-2023-00563.pdf |
| _version_ | 1827769672328544256 |
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| author | Sung Hee Lee Ju Hyun Jin Jong Ha Yoo Shin Won Yoon |
| author_facet | Sung Hee Lee Ju Hyun Jin Jong Ha Yoo Shin Won Yoon |
| author_sort | Sung Hee Lee |
| collection | DOAJ |
| description | Background Limited clinical reports have investigated the effects of maternal coronavirus disease 2019 (COVID-19) on fetuses and neonates. Purpose This retrospective study aimed to assess the impact of maternal COVID-19 on neonates during the perinatal period, including neonatal clinical outcomes, versus the outcomes of neonates of mothers without COVID-19. Methods Neonates born to COVID-19-infected mothers at the National Health Insurance Service Ilsan Hospital between February 2021 and March 2022 were included. Those with gestational age (GA) ≥35+0 weeks who were born within 2 weeks of the maternal infection were matched 1:2 with a control group based on GA. The main outcomes were respiratory diseases, including transient tachypnea of the newborn (TTN), respiratory distress syndrome, meconium aspiration syndrome, the need for respiratory support, and length of hospital stay. Uni- and multivariate logistic regression analyses were performed and adjusted for relevant covariates, including maternal age, obstetric complications (hypertension and gestational diabetes), delivery mode, birth weight, sex, and small-for-gestational-age status. Results The case group comprised 103 neonates (mean GA, 38.5±1.3 weeks; mean birth weight, 3,121±397 g), while the control group included 206 neonates (mean GA, 38.4±1.2 weeks; mean birth weight, 3088±428 g). In the case and control groups, the proportion of cesarean sections was 91% and 40%, respectively, while the proportion of male infants was 56% and 47%, respectively. After adjusting for covariates, the case group had a higher risk of TTN (adjusted odd ratio [AOR], 3.69; 95% confidence interval [CI], 1.69–8.07), noninvasive respiratory ventilator use (AOR, 2.28; 95% CI, 1.05–4.97), and oxygen support (AOR, 4.83; 95% CI, 1.46–15.95). Conclusion Newborns born to COVID-19-infected mothers are at increased risk of TTN and may require respiratory support. Close monitoring of respiratory symptoms is crucial in neonates. |
| first_indexed | 2024-03-11T12:28:46Z |
| format | Article |
| id | doaj.art-8d3fbf1316ba43ecbd4654bb81ca6f47 |
| institution | Directory Open Access Journal |
| issn | 2713-4148 |
| language | English |
| last_indexed | 2024-03-11T12:28:46Z |
| publishDate | 2023-11-01 |
| publisher | The Korean Pediatric Society |
| record_format | Article |
| series | Clinical and Experimental Pediatrics |
| spelling | doaj.art-8d3fbf1316ba43ecbd4654bb81ca6f472023-11-06T04:38:05ZengThe Korean Pediatric SocietyClinical and Experimental Pediatrics2713-41482023-11-01661149350010.3345/cep.2023.0056320125555658Association between maternal coronavirus disease 2019 and transient tachypnea of the newborn: a single-center studySung Hee Lee0Ju Hyun Jin1Jong Ha Yoo2Shin Won Yoon3 Department of Pediatrics, National Health Insurance Service Ilsan Hospital, Goyang, Korea Department of Pediatrics, National Health Insurance Service Ilsan Hospital, Goyang, Korea Department of Laboratory Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea Department of Pediatrics, National Health Insurance Service Ilsan Hospital, Goyang, KoreaBackground Limited clinical reports have investigated the effects of maternal coronavirus disease 2019 (COVID-19) on fetuses and neonates. Purpose This retrospective study aimed to assess the impact of maternal COVID-19 on neonates during the perinatal period, including neonatal clinical outcomes, versus the outcomes of neonates of mothers without COVID-19. Methods Neonates born to COVID-19-infected mothers at the National Health Insurance Service Ilsan Hospital between February 2021 and March 2022 were included. Those with gestational age (GA) ≥35+0 weeks who were born within 2 weeks of the maternal infection were matched 1:2 with a control group based on GA. The main outcomes were respiratory diseases, including transient tachypnea of the newborn (TTN), respiratory distress syndrome, meconium aspiration syndrome, the need for respiratory support, and length of hospital stay. Uni- and multivariate logistic regression analyses were performed and adjusted for relevant covariates, including maternal age, obstetric complications (hypertension and gestational diabetes), delivery mode, birth weight, sex, and small-for-gestational-age status. Results The case group comprised 103 neonates (mean GA, 38.5±1.3 weeks; mean birth weight, 3,121±397 g), while the control group included 206 neonates (mean GA, 38.4±1.2 weeks; mean birth weight, 3088±428 g). In the case and control groups, the proportion of cesarean sections was 91% and 40%, respectively, while the proportion of male infants was 56% and 47%, respectively. After adjusting for covariates, the case group had a higher risk of TTN (adjusted odd ratio [AOR], 3.69; 95% confidence interval [CI], 1.69–8.07), noninvasive respiratory ventilator use (AOR, 2.28; 95% CI, 1.05–4.97), and oxygen support (AOR, 4.83; 95% CI, 1.46–15.95). Conclusion Newborns born to COVID-19-infected mothers are at increased risk of TTN and may require respiratory support. Close monitoring of respiratory symptoms is crucial in neonates.http://www.e-cep.org/upload/pdf/cep-2023-00563.pdfnewborncovid-19 mothersars-cov-2outcomes |
| spellingShingle | Sung Hee Lee Ju Hyun Jin Jong Ha Yoo Shin Won Yoon Association between maternal coronavirus disease 2019 and transient tachypnea of the newborn: a single-center study Clinical and Experimental Pediatrics newborn covid-19 mother sars-cov-2 outcomes |
| title | Association between maternal coronavirus disease 2019 and transient tachypnea of the newborn: a single-center study |
| title_full | Association between maternal coronavirus disease 2019 and transient tachypnea of the newborn: a single-center study |
| title_fullStr | Association between maternal coronavirus disease 2019 and transient tachypnea of the newborn: a single-center study |
| title_full_unstemmed | Association between maternal coronavirus disease 2019 and transient tachypnea of the newborn: a single-center study |
| title_short | Association between maternal coronavirus disease 2019 and transient tachypnea of the newborn: a single-center study |
| title_sort | association between maternal coronavirus disease 2019 and transient tachypnea of the newborn a single center study |
| topic | newborn covid-19 mother sars-cov-2 outcomes |
| url | http://www.e-cep.org/upload/pdf/cep-2023-00563.pdf |
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