Targeting FGFR3 signaling and drug repurposing for the treatment of SLC26A2-related chondrodysplasia in mouse model

Targeting FGFR3 signaling and drug repurposing for the treatment of SLC26A2-related chondrodysplasia in mouse model

Background: Mutations in Slc26a2 cause a spectrum of autosomal-recessive chondrodysplasia with a significant and negligible influence on the quality of life. It has been reported that Slc26a2 deficiency triggers the ATF6 branch of the UPR, which may, in turn, activate the negative regulator of the F...

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Bibliographic Details
Main Authors: Pan Li, Dong Wang, Weiguang Lu, Xin He, Jingyan Hu, Haitao Yun, Chengxiang Zhao, Liu Yang, Qiang Jie, Zhuojing Luo
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Journal of Orthopaedic Translation
Subjects:
SLC26A2
Chondrodysplasia
FGFR3 signaling
NVP-BGJ398
Drug repurposing
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X23000645

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http://www.sciencedirect.com/science/article/pii/S2214031X23000645

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