2型糖尿病终末期肾病和死亡危险因素的性别差异:一项回顾性队列研究
Abstract Background This study investigated the sex differences in the risk of end‐stage kidney disease (ESKD) and mortality, as well as the effect modification of sex on associated factors in patients with type 2 diabetes. Methods This multicenter observational cohort study included 4328 patients w...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Journal of Diabetes |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1753-0407.13367 |
| _version_ | 1797861157059428352 |
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| author | Megumi Oshima Yasunori Iwata Tadashi Toyama Shinji Kitajima Akinori Hara Norihiko Sakai Miho Shimizu Kengo Furuichi Masakazu Haneda Tetsuya Babazono Hiroki Yokoyama Kunitoshi Iseki Shinichi Araki Toshiharu Ninomiya Shigeko Hara Yoshiki Suzuki Masayuki Iwano Eiji Kusano Tatsumi Moriya Hiroaki Satoh Hiroyuki Nakamura Hirofumi Makino Takashi Wada |
| author_facet | Megumi Oshima Yasunori Iwata Tadashi Toyama Shinji Kitajima Akinori Hara Norihiko Sakai Miho Shimizu Kengo Furuichi Masakazu Haneda Tetsuya Babazono Hiroki Yokoyama Kunitoshi Iseki Shinichi Araki Toshiharu Ninomiya Shigeko Hara Yoshiki Suzuki Masayuki Iwano Eiji Kusano Tatsumi Moriya Hiroaki Satoh Hiroyuki Nakamura Hirofumi Makino Takashi Wada |
| author_sort | Megumi Oshima |
| collection | DOAJ |
| description | Abstract Background This study investigated the sex differences in the risk of end‐stage kidney disease (ESKD) and mortality, as well as the effect modification of sex on associated factors in patients with type 2 diabetes. Methods This multicenter observational cohort study included 4328 patients with type 2 diabetes. Hazard ratios (HRs) with 95% confidence intervals (CIs) of sex for ESKD and death were estimated using Cox proportional regression with adjustment for baseline covariates. For assessing risk modification, HRs and incidence rates for ESKD and death were compared between sexes across patient characteristics using Cox proportional and Poisson regression models. Results During a median follow‐up of 7 years, 276 patients (70% men) developed ESKD, and 241 patients (68% men) died. Men had higher risks of ESKD (HR 1.34; 95% CI 1.02–1.75; p = .034) and death (HR 1.64; 95% CI 1.24–2.16; p = .001) versus women after adjusting for multiple covariates. Among patients with microalbuminuria, men had a substantially higher risk of ESKD versus women, compared to those with normo‐ and macroalbuminuria (p for interaction .04). Incidence rates were also increased in men versus women with albuminuria of around 300 mg/g. No differences were detected in the association of sex and death across baseline patient subgroups. Conclusions In type 2 diabetes, men had an increased risk of ESKD and death versus women. Moderately increased albuminuria was strongly associated with sex difference in developing ESKD. |
| first_indexed | 2024-04-09T21:58:45Z |
| format | Article |
| id | doaj.art-8d44beca152a467188bf2c623f65f140 |
| institution | Directory Open Access Journal |
| issn | 1753-0393 1753-0407 |
| language | English |
| last_indexed | 2024-04-09T21:58:45Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj.art-8d44beca152a467188bf2c623f65f1402023-03-24T03:20:06ZengWileyJournal of Diabetes1753-03931753-04072023-03-0115324625410.1111/1753-0407.133672型糖尿病终末期肾病和死亡危险因素的性别差异:一项回顾性队列研究Megumi Oshima0Yasunori Iwata1Tadashi Toyama2Shinji Kitajima3Akinori Hara4Norihiko Sakai5Miho Shimizu6Kengo Furuichi7Masakazu Haneda8Tetsuya Babazono9Hiroki Yokoyama10Kunitoshi Iseki11Shinichi Araki12Toshiharu Ninomiya13Shigeko Hara14Yoshiki Suzuki15Masayuki Iwano16Eiji Kusano17Tatsumi Moriya18Hiroaki Satoh19Hiroyuki Nakamura20Hirofumi Makino21Takashi Wada22Department of Nephrology and Laboratory Medicine Kanazawa University Kanazawa JapanDepartment of Nephrology and Laboratory Medicine Kanazawa University Kanazawa JapanDepartment of Nephrology and Laboratory Medicine Kanazawa University Kanazawa JapanDepartment of Nephrology and Laboratory Medicine Kanazawa University Kanazawa JapanDepartment of Nephrology and Laboratory Medicine Kanazawa University Kanazawa JapanDepartment of Nephrology and Laboratory Medicine Kanazawa University Kanazawa JapanDepartment of Nephrology and Laboratory Medicine Kanazawa University Kanazawa JapanDepartment of Nephrology Kanazawa Medical University Uchinada JapanDepartment of Medicine Asahikawa Medical University Asahikawa JapanDivision of Diabetology and Metabolism, Department of Internal Medicine Tokyo Women's Medical University School of Medicine Tokyo JapanJiyugaoka Medical Clinic, Internal Medicine Obihiro JapanOkinawa Heart and Renal Association Naha JapanDivision of Nephrology, Department of Internal Medicine Wakayama Medical University Wakayama JapanDepartment of Epidemiology and Public Health Graduate School of Medical Sciences, Kyushu University Fukuoka JapanCenter of Health Management, Toranomon Hospital Tokyo JapanNiigata University Medical and Dental Hospital Niigata JapanDepartment of Nephrology Faculty of Medical Sciences, University of Fukui Fukui JapanDivision of Nephrology, Department of Internal Medicine Jichi Medical University Tochigi JapanHealth Care Center, Kitasato University Sagamihara JapanDepartment of Diabetes and Endocrinology Juntendo University Urayasu Hospital Chiba JapanInnovative Clinical Research Center Kanazawa University Kanazawa JapanOkayama University Okayama JapanDepartment of Nephrology and Laboratory Medicine Kanazawa University Kanazawa JapanAbstract Background This study investigated the sex differences in the risk of end‐stage kidney disease (ESKD) and mortality, as well as the effect modification of sex on associated factors in patients with type 2 diabetes. Methods This multicenter observational cohort study included 4328 patients with type 2 diabetes. Hazard ratios (HRs) with 95% confidence intervals (CIs) of sex for ESKD and death were estimated using Cox proportional regression with adjustment for baseline covariates. For assessing risk modification, HRs and incidence rates for ESKD and death were compared between sexes across patient characteristics using Cox proportional and Poisson regression models. Results During a median follow‐up of 7 years, 276 patients (70% men) developed ESKD, and 241 patients (68% men) died. Men had higher risks of ESKD (HR 1.34; 95% CI 1.02–1.75; p = .034) and death (HR 1.64; 95% CI 1.24–2.16; p = .001) versus women after adjusting for multiple covariates. Among patients with microalbuminuria, men had a substantially higher risk of ESKD versus women, compared to those with normo‐ and macroalbuminuria (p for interaction .04). Incidence rates were also increased in men versus women with albuminuria of around 300 mg/g. No differences were detected in the association of sex and death across baseline patient subgroups. Conclusions In type 2 diabetes, men had an increased risk of ESKD and death versus women. Moderately increased albuminuria was strongly associated with sex difference in developing ESKD.https://doi.org/10.1111/1753-0407.13367性别差异2型糖尿病终末期肾脏疾病白蛋白尿死亡 |
| spellingShingle | Megumi Oshima Yasunori Iwata Tadashi Toyama Shinji Kitajima Akinori Hara Norihiko Sakai Miho Shimizu Kengo Furuichi Masakazu Haneda Tetsuya Babazono Hiroki Yokoyama Kunitoshi Iseki Shinichi Araki Toshiharu Ninomiya Shigeko Hara Yoshiki Suzuki Masayuki Iwano Eiji Kusano Tatsumi Moriya Hiroaki Satoh Hiroyuki Nakamura Hirofumi Makino Takashi Wada 2型糖尿病终末期肾病和死亡危险因素的性别差异:一项回顾性队列研究 Journal of Diabetes 性别差异 2型糖尿病 终末期肾脏疾病 白蛋白尿 死亡 |
| title | 2型糖尿病终末期肾病和死亡危险因素的性别差异:一项回顾性队列研究 |
| title_full | 2型糖尿病终末期肾病和死亡危险因素的性别差异:一项回顾性队列研究 |
| title_fullStr | 2型糖尿病终末期肾病和死亡危险因素的性别差异:一项回顾性队列研究 |
| title_full_unstemmed | 2型糖尿病终末期肾病和死亡危险因素的性别差异:一项回顾性队列研究 |
| title_short | 2型糖尿病终末期肾病和死亡危险因素的性别差异:一项回顾性队列研究 |
| title_sort | 2型糖尿病终末期肾病和死亡危险因素的性别差异 一项回顾性队列研究 |
| topic | 性别差异 2型糖尿病 终末期肾脏疾病 白蛋白尿 死亡 |
| url | https://doi.org/10.1111/1753-0407.13367 |
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