Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time?
Chronic low-grade inflammation affects health and is associated with aging and age-related diseases. Dysregulation of the gut flora is an important trigger for chronic low-grade inflammation. Changes in the composition of the gut flora and exposure to related metabolites have an effect on the inflam...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1178596/full |
| _version_ | 1797814286400094208 |
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| author | Jing Ren Jing Ren Huimin Li Guixing Zeng Boxian Pang Boxian Pang Qiuhong Wang Junping Wei |
| author_facet | Jing Ren Jing Ren Huimin Li Guixing Zeng Boxian Pang Boxian Pang Qiuhong Wang Junping Wei |
| author_sort | Jing Ren |
| collection | DOAJ |
| description | Chronic low-grade inflammation affects health and is associated with aging and age-related diseases. Dysregulation of the gut flora is an important trigger for chronic low-grade inflammation. Changes in the composition of the gut flora and exposure to related metabolites have an effect on the inflammatory system of the host. This results in the development of crosstalk between the gut barrier and immune system, contributing to chronic low-grade inflammation and impairment of health. Probiotics can increase the diversity of gut microbiota, protect the gut barrier, and regulate gut immunity, thereby reducing inflammation. Therefore, the use of probiotics is a promising strategy for the beneficial immunomodulation and protection of the gut barrier through gut microbiota. These processes might positively influence inflammatory diseases, which are common in the elderly. |
| first_indexed | 2024-03-13T08:05:22Z |
| format | Article |
| id | doaj.art-8d4bdd5ec9ce46608cbbeef064f7c42a |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-13T08:05:22Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-8d4bdd5ec9ce46608cbbeef064f7c42a2023-06-01T05:17:48ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-06-011410.3389/fphar.2023.11785961178596Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time?Jing Ren0Jing Ren1Huimin Li2Guixing Zeng3Boxian Pang4Boxian Pang5Qiuhong Wang6Junping Wei7Department of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGraduate School of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGraduate School of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaChronic low-grade inflammation affects health and is associated with aging and age-related diseases. Dysregulation of the gut flora is an important trigger for chronic low-grade inflammation. Changes in the composition of the gut flora and exposure to related metabolites have an effect on the inflammatory system of the host. This results in the development of crosstalk between the gut barrier and immune system, contributing to chronic low-grade inflammation and impairment of health. Probiotics can increase the diversity of gut microbiota, protect the gut barrier, and regulate gut immunity, thereby reducing inflammation. Therefore, the use of probiotics is a promising strategy for the beneficial immunomodulation and protection of the gut barrier through gut microbiota. These processes might positively influence inflammatory diseases, which are common in the elderly.https://www.frontiersin.org/articles/10.3389/fphar.2023.1178596/fullprobioticsinflammationgut microbiotaintestinal barrierdysbiosiselderly |
| spellingShingle | Jing Ren Jing Ren Huimin Li Guixing Zeng Boxian Pang Boxian Pang Qiuhong Wang Junping Wei Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time? Frontiers in Pharmacology probiotics inflammation gut microbiota intestinal barrier dysbiosis elderly |
| title | Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time? |
| title_full | Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time? |
| title_fullStr | Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time? |
| title_full_unstemmed | Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time? |
| title_short | Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time? |
| title_sort | gut microbiome mediated mechanisms in aging related diseases are probiotics ready for prime time |
| topic | probiotics inflammation gut microbiota intestinal barrier dysbiosis elderly |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1178596/full |
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