The Myocardial Ischemia Reduction with Acute Cholesterol Lowering trial: MIRACuLous or not, it's time to change current practice
<p>Abstract</p> <p>The Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) study was the first trial to assess whether statins might be of clinical benefit in those with recently <it>unstable</it> coronary disease. MIRACL found that high-dose ato...
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| Format: | Article |
| Language: | English |
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BMC
2002-01-01
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| Series: | Current Controlled Trials in Cardiovascular Medicine |
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| Online Access: | http://www.biomedcentral.com/1468-6708/3/3 |
| _version_ | 1811317954835382272 |
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| author | Aronow Herbert D |
| author_facet | Aronow Herbert D |
| author_sort | Aronow Herbert D |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) study was the first trial to assess whether statins might be of clinical benefit in those with recently <it>unstable</it> coronary disease. MIRACL found that high-dose atorvastatin was safe and reduced the incidence of the composite endpoint, death, non-fatal myocardial infarction, resuscitated sudden cardiac death or emergent rehospitalization for recurrent ischemia at 16 weeks when compared with placebo. Despite a number of important study limitations, MIRACL's findings and the prior observation that inpatient initiation of lipid-lowering therapy is associated with higher rates of subsequent utilization, suggest that it is prudent to begin statin therapy when patients present with an acute coronary syndrome.</p> |
| first_indexed | 2024-04-13T12:18:37Z |
| format | Article |
| id | doaj.art-8d4c0c30127d4d2ba3f891ff51edc480 |
| institution | Directory Open Access Journal |
| issn | 1468-6708 |
| language | English |
| last_indexed | 2024-04-13T12:18:37Z |
| publishDate | 2002-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Current Controlled Trials in Cardiovascular Medicine |
| spelling | doaj.art-8d4c0c30127d4d2ba3f891ff51edc4802022-12-22T02:47:18ZengBMCCurrent Controlled Trials in Cardiovascular Medicine1468-67082002-01-0131310.1186/1468-6708-3-3The Myocardial Ischemia Reduction with Acute Cholesterol Lowering trial: MIRACuLous or not, it's time to change current practiceAronow Herbert D<p>Abstract</p> <p>The Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) study was the first trial to assess whether statins might be of clinical benefit in those with recently <it>unstable</it> coronary disease. MIRACL found that high-dose atorvastatin was safe and reduced the incidence of the composite endpoint, death, non-fatal myocardial infarction, resuscitated sudden cardiac death or emergent rehospitalization for recurrent ischemia at 16 weeks when compared with placebo. Despite a number of important study limitations, MIRACL's findings and the prior observation that inpatient initiation of lipid-lowering therapy is associated with higher rates of subsequent utilization, suggest that it is prudent to begin statin therapy when patients present with an acute coronary syndrome.</p>http://www.biomedcentral.com/1468-6708/3/3myocardial infarctionunstable anginaHMG-CoAreductase inhibitorsmyocardial ischemia |
| spellingShingle | Aronow Herbert D The Myocardial Ischemia Reduction with Acute Cholesterol Lowering trial: MIRACuLous or not, it's time to change current practice Current Controlled Trials in Cardiovascular Medicine myocardial infarction unstable angina HMG-CoA reductase inhibitors myocardial ischemia |
| title | The Myocardial Ischemia Reduction with Acute Cholesterol Lowering trial: MIRACuLous or not, it's time to change current practice |
| title_full | The Myocardial Ischemia Reduction with Acute Cholesterol Lowering trial: MIRACuLous or not, it's time to change current practice |
| title_fullStr | The Myocardial Ischemia Reduction with Acute Cholesterol Lowering trial: MIRACuLous or not, it's time to change current practice |
| title_full_unstemmed | The Myocardial Ischemia Reduction with Acute Cholesterol Lowering trial: MIRACuLous or not, it's time to change current practice |
| title_short | The Myocardial Ischemia Reduction with Acute Cholesterol Lowering trial: MIRACuLous or not, it's time to change current practice |
| title_sort | myocardial ischemia reduction with acute cholesterol lowering trial miraculous or not it s time to change current practice |
| topic | myocardial infarction unstable angina HMG-CoA reductase inhibitors myocardial ischemia |
| url | http://www.biomedcentral.com/1468-6708/3/3 |
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