Particle Therapy: Clinical Applications and Biological Effects
Particle therapy is a developing area of radiotherapy, mostly involving the use of protons, neutrons and carbon ions for cancer treatment. The reduction of side effects on healthy tissues in the peritumoral area is an important advantage of particle therapy. In this review, we analyze state-of-the-a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/12/2071 |
| _version_ | 1797456667601797120 |
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| author | Viktoriia Kiseleva Konstantin Gordon Polina Vishnyakova Elena Gantsova Andrey Elchaninov Timur Fatkhudinov |
| author_facet | Viktoriia Kiseleva Konstantin Gordon Polina Vishnyakova Elena Gantsova Andrey Elchaninov Timur Fatkhudinov |
| author_sort | Viktoriia Kiseleva |
| collection | DOAJ |
| description | Particle therapy is a developing area of radiotherapy, mostly involving the use of protons, neutrons and carbon ions for cancer treatment. The reduction of side effects on healthy tissues in the peritumoral area is an important advantage of particle therapy. In this review, we analyze state-of-the-art particle therapy, as compared to conventional photon therapy, to identify clinical benefits and specify the mechanisms of action on tumor cells. Systematization of published data on particle therapy confirms its successful application in a wide range of cancers and reveals a variety of biological effects which manifest at the molecular level and produce the particle therapy-specific molecular signatures. Given the rapid progress in the field, the use of particle therapy holds great promise for the near future. |
| first_indexed | 2024-03-09T16:11:07Z |
| format | Article |
| id | doaj.art-8d4c3be002a54718924cfb5685675129 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T16:11:07Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-8d4c3be002a54718924cfb56856751292023-11-24T16:13:03ZengMDPI AGLife2075-17292022-12-011212207110.3390/life12122071Particle Therapy: Clinical Applications and Biological EffectsViktoriia Kiseleva0Konstantin Gordon1Polina Vishnyakova2Elena Gantsova3Andrey Elchaninov4Timur Fatkhudinov5National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 117198 Moscow, RussiaResearch Institute of Molecular and Cellular Medicine, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, RussiaNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 117198 Moscow, RussiaResearch Institute of Molecular and Cellular Medicine, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, RussiaNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 117198 Moscow, RussiaResearch Institute of Molecular and Cellular Medicine, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, RussiaParticle therapy is a developing area of radiotherapy, mostly involving the use of protons, neutrons and carbon ions for cancer treatment. The reduction of side effects on healthy tissues in the peritumoral area is an important advantage of particle therapy. In this review, we analyze state-of-the-art particle therapy, as compared to conventional photon therapy, to identify clinical benefits and specify the mechanisms of action on tumor cells. Systematization of published data on particle therapy confirms its successful application in a wide range of cancers and reveals a variety of biological effects which manifest at the molecular level and produce the particle therapy-specific molecular signatures. Given the rapid progress in the field, the use of particle therapy holds great promise for the near future.https://www.mdpi.com/2075-1729/12/12/2071particle therapyhadron therapyprotonscarbonsneutronsgenes |
| spellingShingle | Viktoriia Kiseleva Konstantin Gordon Polina Vishnyakova Elena Gantsova Andrey Elchaninov Timur Fatkhudinov Particle Therapy: Clinical Applications and Biological Effects Life particle therapy hadron therapy protons carbons neutrons genes |
| title | Particle Therapy: Clinical Applications and Biological Effects |
| title_full | Particle Therapy: Clinical Applications and Biological Effects |
| title_fullStr | Particle Therapy: Clinical Applications and Biological Effects |
| title_full_unstemmed | Particle Therapy: Clinical Applications and Biological Effects |
| title_short | Particle Therapy: Clinical Applications and Biological Effects |
| title_sort | particle therapy clinical applications and biological effects |
| topic | particle therapy hadron therapy protons carbons neutrons genes |
| url | https://www.mdpi.com/2075-1729/12/12/2071 |
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