Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure
ABSTRACT INTRODUCTION: This study evaluated the susceptibilities of oral candidiasis-derived Candida albicans, fluconazole-resistant (FR) Candida dubliniensis, and fluconazole-susceptible (FS) C. dubliniensis to synthetic antiseptics [chlorhexidine gluconate (CHX), cetylpyridinium chloride (CPC),...
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Sociedade Brasileira de Medicina Tropical (SBMT)
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100075&lng=en&tlng=en |
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| author | Cássia Franco Reginato Laíssa Arévalo Bandeira Régis Adriel Zanette Janio Morais Santurio Sydney Hartz Alves Cristiane Cademartori Danesi |
| author_facet | Cássia Franco Reginato Laíssa Arévalo Bandeira Régis Adriel Zanette Janio Morais Santurio Sydney Hartz Alves Cristiane Cademartori Danesi |
| author_sort | Cássia Franco Reginato |
| collection | DOAJ |
| description | ABSTRACT INTRODUCTION: This study evaluated the susceptibilities of oral candidiasis-derived Candida albicans, fluconazole-resistant (FR) Candida dubliniensis, and fluconazole-susceptible (FS) C. dubliniensis to synthetic antiseptics [chlorhexidine gluconate (CHX), cetylpyridinium chloride (CPC), and triclosan (TRC)] and natural compounds (carvacrol, eugenol and thymol). METHODS: Susceptibility tests were performed based on the M27-A3 reference method. The fluconazole-resistant C. dubliniensis strains were obtained after prolonged in vitro exposure to increasing fluconazole concentrations. The geometric mean values for minimum inhibitory concentrations and minimum fungicidal concentrations were compared among the groups. RESULTS: Fluconazole-susceptible C. dubliniensis was more sensitive to CPC and TRC than FR C. dubliniensis and C. albicans were. However, eugenol and thymol were more active against FR C. dubliniensis. The fungicidal activities of CHX and TRC were similar for the three groups, and FR C. dubliniensis and C. albicans had similar sensitivities to CPC. CONCLUSIONS: The resistance of C. dubliniensis to fluconazole affects its sensitivity the synthetic antiseptics and natural compounds that were tested. |
| first_indexed | 2024-04-13T22:38:19Z |
| format | Article |
| id | doaj.art-8d4c4b75de82496e939e5bcdaed8acf1 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-13T22:38:19Z |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-8d4c4b75de82496e939e5bcdaed8acf12022-12-22T02:26:43ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-9849501757910.1590/0037-8682-0461-2016S0037-86822017000100075Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposureCássia Franco ReginatoLaíssa Arévalo BandeiraRégis Adriel ZanetteJanio Morais SanturioSydney Hartz AlvesCristiane Cademartori DanesiABSTRACT INTRODUCTION: This study evaluated the susceptibilities of oral candidiasis-derived Candida albicans, fluconazole-resistant (FR) Candida dubliniensis, and fluconazole-susceptible (FS) C. dubliniensis to synthetic antiseptics [chlorhexidine gluconate (CHX), cetylpyridinium chloride (CPC), and triclosan (TRC)] and natural compounds (carvacrol, eugenol and thymol). METHODS: Susceptibility tests were performed based on the M27-A3 reference method. The fluconazole-resistant C. dubliniensis strains were obtained after prolonged in vitro exposure to increasing fluconazole concentrations. The geometric mean values for minimum inhibitory concentrations and minimum fungicidal concentrations were compared among the groups. RESULTS: Fluconazole-susceptible C. dubliniensis was more sensitive to CPC and TRC than FR C. dubliniensis and C. albicans were. However, eugenol and thymol were more active against FR C. dubliniensis. The fungicidal activities of CHX and TRC were similar for the three groups, and FR C. dubliniensis and C. albicans had similar sensitivities to CPC. CONCLUSIONS: The resistance of C. dubliniensis to fluconazole affects its sensitivity the synthetic antiseptics and natural compounds that were tested.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100075&lng=en&tlng=enAntisepticsSusceptibilityCandida dubliniensis |
| spellingShingle | Cássia Franco Reginato Laíssa Arévalo Bandeira Régis Adriel Zanette Janio Morais Santurio Sydney Hartz Alves Cristiane Cademartori Danesi Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure Revista da Sociedade Brasileira de Medicina Tropical Antiseptics Susceptibility Candida dubliniensis |
| title | Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure |
| title_full | Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure |
| title_fullStr | Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure |
| title_full_unstemmed | Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure |
| title_short | Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure |
| title_sort | antifungal activity of synthetic antiseptics and natural compounds against candida dubliniensis before and after in vitro fluconazole exposure |
| topic | Antiseptics Susceptibility Candida dubliniensis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100075&lng=en&tlng=en |
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