Effects of carbon nanofiber on physiology of Drosophila
Shin-Hae Lee,1,* Hye-Yeon Lee,1,* Eun-Ji Lee,1,* Dongwoo Khang,2 Kyung-Jin Min11Department of Biological Sciences, Inha University, Incheon, Republic of Korea; 2Department of Molecular Medicine, Graduate School of Medicine, Gachon University, Incheon, Republic of Korea*These authors contributed equa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2015-05-01
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| Series: | International Journal of Nanomedicine |
| Online Access: | http://www.dovepress.com/effects-of-carbon-nanofiber-on-physiology-of-drosophila-peer-reviewed-article-IJN |
| _version_ | 1823962667241439232 |
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| author | Lee SH Lee HY Lee EJ Khang D Min KJ |
| author_facet | Lee SH Lee HY Lee EJ Khang D Min KJ |
| author_sort | Lee SH |
| collection | DOAJ |
| description | Shin-Hae Lee,1,* Hye-Yeon Lee,1,* Eun-Ji Lee,1,* Dongwoo Khang,2 Kyung-Jin Min11Department of Biological Sciences, Inha University, Incheon, Republic of Korea; 2Department of Molecular Medicine, Graduate School of Medicine, Gachon University, Incheon, Republic of Korea*These authors contributed equally to this workAbstract: As nanomaterials are now widely utilized in a wide range of fields for both medical and industrial applications, concerns over their potential toxicity to human health and the environment have increased. To evaluate the toxicity of long-term exposure to carbon nanofibers (CNFs) in an in vivo system, we selected Drosophila melanogaster as a model organism. Oral administration of CNFs at a concentration of 1,000 µg/mL had adverse effects on fly physiology. Long-term administration of a high dose of CNFs (1,000 µg/mL) reduced larval viability based on the pupa:egg ratio, adult fly lifespan, reproductive activity, climbing activity, and survival rate in response to starvation stress. However, CNFs at a low concentration (100 µg/mL) did not show any significant deleterious effect on developmental rate or fecundity. Furthermore, long-term administration of a low dose of CNFs (100 µg/mL) increased lifespan and climbing ability, coincident with mild reactive oxygen species generation and stimulation of the antioxidant system. Taken together, our data suggest that a high dose of CNFs has obvious physiological toxicity, whereas low-dose chronic exposure to CNFs can actually have beneficial effects via stimulation of the antioxidant defense system.Keywords: toxicity, Drosophila melanogaster, lifespan, reactive oxygen species |
| first_indexed | 2024-12-17T17:19:34Z |
| format | Article |
| id | doaj.art-8d4cd29bdb214348bcc5357a15817fa9 |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-17T17:19:34Z |
| publishDate | 2015-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-8d4cd29bdb214348bcc5357a15817fa92022-12-21T21:39:49ZengDove Medical PressInternational Journal of Nanomedicine1178-20132015-05-012015default3687369721849Effects of carbon nanofiber on physiology of DrosophilaLee SHLee HYLee EJKhang DMin KJShin-Hae Lee,1,* Hye-Yeon Lee,1,* Eun-Ji Lee,1,* Dongwoo Khang,2 Kyung-Jin Min11Department of Biological Sciences, Inha University, Incheon, Republic of Korea; 2Department of Molecular Medicine, Graduate School of Medicine, Gachon University, Incheon, Republic of Korea*These authors contributed equally to this workAbstract: As nanomaterials are now widely utilized in a wide range of fields for both medical and industrial applications, concerns over their potential toxicity to human health and the environment have increased. To evaluate the toxicity of long-term exposure to carbon nanofibers (CNFs) in an in vivo system, we selected Drosophila melanogaster as a model organism. Oral administration of CNFs at a concentration of 1,000 µg/mL had adverse effects on fly physiology. Long-term administration of a high dose of CNFs (1,000 µg/mL) reduced larval viability based on the pupa:egg ratio, adult fly lifespan, reproductive activity, climbing activity, and survival rate in response to starvation stress. However, CNFs at a low concentration (100 µg/mL) did not show any significant deleterious effect on developmental rate or fecundity. Furthermore, long-term administration of a low dose of CNFs (100 µg/mL) increased lifespan and climbing ability, coincident with mild reactive oxygen species generation and stimulation of the antioxidant system. Taken together, our data suggest that a high dose of CNFs has obvious physiological toxicity, whereas low-dose chronic exposure to CNFs can actually have beneficial effects via stimulation of the antioxidant defense system.Keywords: toxicity, Drosophila melanogaster, lifespan, reactive oxygen specieshttp://www.dovepress.com/effects-of-carbon-nanofiber-on-physiology-of-drosophila-peer-reviewed-article-IJN |
| spellingShingle | Lee SH Lee HY Lee EJ Khang D Min KJ Effects of carbon nanofiber on physiology of Drosophila International Journal of Nanomedicine |
| title | Effects of carbon nanofiber on physiology of Drosophila |
| title_full | Effects of carbon nanofiber on physiology of Drosophila |
| title_fullStr | Effects of carbon nanofiber on physiology of Drosophila |
| title_full_unstemmed | Effects of carbon nanofiber on physiology of Drosophila |
| title_short | Effects of carbon nanofiber on physiology of Drosophila |
| title_sort | effects of carbon nanofiber on physiology of drosophila |
| url | http://www.dovepress.com/effects-of-carbon-nanofiber-on-physiology-of-drosophila-peer-reviewed-article-IJN |
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