Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus
Human cytomegalovirus (HCMV), a clinically important β-herpesvirus, is a master of evasion and modulation of the host immune system, including inhibition of a number of dendritic cell (DC) functions. DCs play a central role in co-ordination of the immune response against pathogens and any disturbanc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-07-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00337/full |
| _version_ | 1819103106023030784 |
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| author | Selmir eAvdic Brian eMcSharry Barry eSlobedman Barry eSlobedman |
| author_facet | Selmir eAvdic Brian eMcSharry Barry eSlobedman Barry eSlobedman |
| author_sort | Selmir eAvdic |
| collection | DOAJ |
| description | Human cytomegalovirus (HCMV), a clinically important β-herpesvirus, is a master of evasion and modulation of the host immune system, including inhibition of a number of dendritic cell (DC) functions. DCs play a central role in co-ordination of the immune response against pathogens and any disturbance of DC functions can result in a cascade effect on a range of immune cells. Recently, the HCMV gene UL111A, which encodes viral homologs of human interleukin 10, has been identified as a strong suppressor of a number of DC functions. In this mini review, we focus on HCMV encoded viral IL-10 mediated inhibitory effects on DCs and implications for the development of an effective HCMV vaccine. |
| first_indexed | 2024-12-22T01:45:11Z |
| format | Article |
| id | doaj.art-8d4decc18f3647e0b716d4b918732ff9 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-22T01:45:11Z |
| publishDate | 2014-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-8d4decc18f3647e0b716d4b918732ff92022-12-21T18:43:05ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2014-07-01510.3389/fmicb.2014.0033799020Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirusSelmir eAvdic0Brian eMcSharry1Barry eSlobedman2Barry eSlobedman3University of SydneyUniversity of SydneyUniversity of SydneyWestmead Millennium InstituteHuman cytomegalovirus (HCMV), a clinically important β-herpesvirus, is a master of evasion and modulation of the host immune system, including inhibition of a number of dendritic cell (DC) functions. DCs play a central role in co-ordination of the immune response against pathogens and any disturbance of DC functions can result in a cascade effect on a range of immune cells. Recently, the HCMV gene UL111A, which encodes viral homologs of human interleukin 10, has been identified as a strong suppressor of a number of DC functions. In this mini review, we focus on HCMV encoded viral IL-10 mediated inhibitory effects on DCs and implications for the development of an effective HCMV vaccine.http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00337/fullCytomegalovirusDendritic CellsImmunomodulationinterleukin 10virus replication and latency |
| spellingShingle | Selmir eAvdic Brian eMcSharry Barry eSlobedman Barry eSlobedman Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus Frontiers in Microbiology Cytomegalovirus Dendritic Cells Immunomodulation interleukin 10 virus replication and latency |
| title | Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus |
| title_full | Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus |
| title_fullStr | Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus |
| title_full_unstemmed | Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus |
| title_short | Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus |
| title_sort | modulation of dendritic cell functions by viral il 10 encoded by human cytomegalovirus |
| topic | Cytomegalovirus Dendritic Cells Immunomodulation interleukin 10 virus replication and latency |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00337/full |
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