Leptin, blood pressure, and left ventricular mass in obese adolescents
Background Obesity is characterized by an excessive accumulation of body fat and has become a major health problem in industrialized societies especially with regards to heart disease. Adipose tissue derived hormone (leptin) can cause obesity. Leptin acts to reduce food consumption and enhance energ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2013-12-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/375 |
| _version_ | 1819034809267126272 |
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| author | David Kaunang Handri Widodo Vivekenanda Pateda |
| author_facet | David Kaunang Handri Widodo Vivekenanda Pateda |
| author_sort | David Kaunang |
| collection | DOAJ |
| description | Background Obesity is characterized by an excessive accumulation
of body fat and has become a major health problem in industrialized
societies especially with regards to heart disease. Adipose tissue
derived hormone (leptin) can cause obesity. Leptin acts to reduce
food consumption and enhance energy expenditure.
Objective To assess for a relationship between leptin, blood
pressure, and left ventricular mass in obese adolescents.
Methods This was a cross-sectional study conducted from
November 2011 to April 2012 in Prof. Dr. RD. Kandou Hospital.
This study included obese and healthy adolescents aged 13-18
years who attended school in Tuminting District ofManado. Each
subject underwent measurements of body mass index (BMI), boold
pressure, and plasma leptin level. Correlation regression test was
used for data analysis. Results were considered to be statistically
significant if P values < 0.05.
Results There was a significant relationship between leptin and
left ventricular mass (r=-0.467; P=0.006), as well as leptin and
systolic blood pressure (r=-0.366; P=0.028), but not between
leptin and diastolic blood pressure (r=-0.261; P=0.09). We also
found significant relationships between systolic blood pressure and
left ventricular mass (r=0.724; P<0.001), and between diastolic
blood pressure and left ventricular mass ( r=0.615; P< 0.001) in
obese adolescents.
Conclusion Higher leptin levels are associated with lower left
ventricular mass and lower systolic blood pressure, but are not
associated with diastolic blood pressure. |
| first_indexed | 2024-12-21T07:39:38Z |
| format | Article |
| id | doaj.art-8d4f2ff7b4f449428db7f14bed083e1d |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-21T07:39:38Z |
| publishDate | 2013-12-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-8d4f2ff7b4f449428db7f14bed083e1d2022-12-21T19:11:21ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2013-12-01536346910.14238/pi53.6.2013.346-9267Leptin, blood pressure, and left ventricular mass in obese adolescentsDavid Kaunang0Handri Widodo1Vivekenanda Pateda2Department of Child Health, Sam Ratulangi University Medical School, Prof. Dr. R. D. Kandou HospitalDepartment of Child Health, Sam Ratulangi University Medical School, Prof. Dr. R. D. Kandou HospitalDepartment of Child Health, Sam Ratulangi University Medical School, Prof. Dr. R. D. Kandou HospitalBackground Obesity is characterized by an excessive accumulation of body fat and has become a major health problem in industrialized societies especially with regards to heart disease. Adipose tissue derived hormone (leptin) can cause obesity. Leptin acts to reduce food consumption and enhance energy expenditure. Objective To assess for a relationship between leptin, blood pressure, and left ventricular mass in obese adolescents. Methods This was a cross-sectional study conducted from November 2011 to April 2012 in Prof. Dr. RD. Kandou Hospital. This study included obese and healthy adolescents aged 13-18 years who attended school in Tuminting District ofManado. Each subject underwent measurements of body mass index (BMI), boold pressure, and plasma leptin level. Correlation regression test was used for data analysis. Results were considered to be statistically significant if P values < 0.05. Results There was a significant relationship between leptin and left ventricular mass (r=-0.467; P=0.006), as well as leptin and systolic blood pressure (r=-0.366; P=0.028), but not between leptin and diastolic blood pressure (r=-0.261; P=0.09). We also found significant relationships between systolic blood pressure and left ventricular mass (r=0.724; P<0.001), and between diastolic blood pressure and left ventricular mass ( r=0.615; P< 0.001) in obese adolescents. Conclusion Higher leptin levels are associated with lower left ventricular mass and lower systolic blood pressure, but are not associated with diastolic blood pressure.https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/375Leptin, blood pressure, left ventricular mass, obesity |
| spellingShingle | David Kaunang Handri Widodo Vivekenanda Pateda Leptin, blood pressure, and left ventricular mass in obese adolescents Paediatrica Indonesiana Leptin, blood pressure, left ventricular mass, obesity |
| title | Leptin, blood pressure, and left ventricular mass in obese adolescents |
| title_full | Leptin, blood pressure, and left ventricular mass in obese adolescents |
| title_fullStr | Leptin, blood pressure, and left ventricular mass in obese adolescents |
| title_full_unstemmed | Leptin, blood pressure, and left ventricular mass in obese adolescents |
| title_short | Leptin, blood pressure, and left ventricular mass in obese adolescents |
| title_sort | leptin blood pressure and left ventricular mass in obese adolescents |
| topic | Leptin, blood pressure, left ventricular mass, obesity |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/375 |
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