Apolipoprotein E (ApoE) orchestrates adipose tissue inflammation and metabolic disorders through NLRP3 inflammasome

Apolipoprotein E (ApoE) orchestrates adipose tissue inflammation and metabolic disorders through NLRP3 inflammasome

Abstract Obesity is a metabolic disorder characterized by the hypertrophy expansion of adipose tissue, resulting in dysregulated energy metabolism, and accompanied by chronic low-grade inflammation. Adipose tissue macrophages (ATMs), a principal component of inflammation, respond to microenvironment...

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Bibliographic Details
Main Authors: Yulin Zhang, Ziwei Cheng, Liyu Hong, Jia Liu, Xinyue Ma, Wenjing Wang, Ran Pan, Wenjie Lu, Qichao Luo, Shan Gao, Qin Kong
Format: Article
Language:English
Published: Springer 2023-12-01
Series:Molecular Biomedicine
Subjects:
Apolipoprotein E (ApoE)
Adipose tissue
Metabolic inflammation
Macrophage
NOD-, LRR- and Pyrin Domain-Containing Protein 3 (NLRP3)
Online Access:https://doi.org/10.1186/s43556-023-00158-8

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