Non-Pathogenic Aspergillus oryzae Acute Exogenous Endophthalmitis after Penetrating Keratoplasty: The First Case Report in the Literature
The authors report a singular case of post-operative exogenous fungal endophthalmitis caused by a non-pathogenic fungal agent: Aspergillus oryzae. A 75-year-old Caucasian woman with post-penetrating keratoplasty fungal endophthalmitis due to a nonpathogenic A. oryzae, resistant to the current azoles...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2023-11-01
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| Series: | Case Reports in Ophthalmology |
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| Online Access: | https://beta.karger.com/Article/FullText/531801 |
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| author | Luigi Mosca Laura Guccione Maria Emanuela Toro Luca Scartozzi Romina Fasciani Riccardo Torelli Maurizio Sanguinetti Stanislao Rizzo |
| author_facet | Luigi Mosca Laura Guccione Maria Emanuela Toro Luca Scartozzi Romina Fasciani Riccardo Torelli Maurizio Sanguinetti Stanislao Rizzo |
| author_sort | Luigi Mosca |
| collection | DOAJ |
| description | The authors report a singular case of post-operative exogenous fungal endophthalmitis caused by a non-pathogenic fungal agent: Aspergillus oryzae. A 75-year-old Caucasian woman with post-penetrating keratoplasty fungal endophthalmitis due to a nonpathogenic A. oryzae, resistant to the current azoles anti-fungal agents, was treated with subtotal vitrectomy, intravitreal injection, and systemic voriconazole therapy. Complete resolution of the endophthalmitis occurred after two subsequent intravitreal injections and a 2-month-long systemic delivery of voriconazole. The quick identification of the fungal agent allowed immediate and targeted therapy. In the article, the safety and efficacy of both systemic and intravitreal voriconazole treatments are discussed. |
| first_indexed | 2024-03-08T21:21:25Z |
| format | Article |
| id | doaj.art-8d50429fd4ec470181943a56a1588c52 |
| institution | Directory Open Access Journal |
| issn | 1663-2699 |
| language | English |
| last_indexed | 2024-03-08T21:21:25Z |
| publishDate | 2023-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Ophthalmology |
| spelling | doaj.art-8d50429fd4ec470181943a56a1588c522023-12-21T10:09:26ZengKarger PublishersCase Reports in Ophthalmology1663-26992023-11-0114165465910.1159/000531801531801Non-Pathogenic Aspergillus oryzae Acute Exogenous Endophthalmitis after Penetrating Keratoplasty: The First Case Report in the LiteratureLuigi Mosca0https://orcid.org/0000-0003-4641-0841Laura Guccione1Maria Emanuela Toro2Luca Scartozzi3https://orcid.org/0000-0003-3571-7717Romina Fasciani4https://orcid.org/0000-0002-0435-1612Riccardo Torelli5Maurizio Sanguinetti6Stanislao Rizzo7Institute of Ophthalmology, Catholic University of Sacred Heart – "Agostino Gemelli" University Polyclinic Foundation – IRCCS, Rome, ItalyInstitute of Ophthalmology, Catholic University of Sacred Heart – "Agostino Gemelli" University Polyclinic Foundation – IRCCS, Rome, ItalyInstitute of Ophthalmology, Catholic University of Sacred Heart – "Agostino Gemelli" University Polyclinic Foundation – IRCCS, Rome, ItalyInstitute of Ophthalmology, Catholic University of Sacred Heart – "Agostino Gemelli" University Polyclinic Foundation – IRCCS, Rome, ItalyInstitute of Ophthalmology, Catholic University of Sacred Heart – "Agostino Gemelli" University Polyclinic Foundation – IRCCS, Rome, ItalyDepartment of Microbiology, Catholic University of Sacred Heart – "Agostino Gemelli" University Polyclinic Foundation – IRCCS, Rome, ItalyDepartment of Microbiology, Catholic University of Sacred Heart – "Agostino Gemelli" University Polyclinic Foundation – IRCCS, Rome, ItalyInstitute of Ophthalmology, Catholic University of Sacred Heart – "Agostino Gemelli" University Polyclinic Foundation – IRCCS, Rome, ItalyThe authors report a singular case of post-operative exogenous fungal endophthalmitis caused by a non-pathogenic fungal agent: Aspergillus oryzae. A 75-year-old Caucasian woman with post-penetrating keratoplasty fungal endophthalmitis due to a nonpathogenic A. oryzae, resistant to the current azoles anti-fungal agents, was treated with subtotal vitrectomy, intravitreal injection, and systemic voriconazole therapy. Complete resolution of the endophthalmitis occurred after two subsequent intravitreal injections and a 2-month-long systemic delivery of voriconazole. The quick identification of the fungal agent allowed immediate and targeted therapy. In the article, the safety and efficacy of both systemic and intravitreal voriconazole treatments are discussed.https://beta.karger.com/Article/FullText/531801anti-fungal agentcase reportaspergillus oryzaefungal endophthalmitispenetrating keratoplasty complicationsvoriconazole |
| spellingShingle | Luigi Mosca Laura Guccione Maria Emanuela Toro Luca Scartozzi Romina Fasciani Riccardo Torelli Maurizio Sanguinetti Stanislao Rizzo Non-Pathogenic Aspergillus oryzae Acute Exogenous Endophthalmitis after Penetrating Keratoplasty: The First Case Report in the Literature Case Reports in Ophthalmology anti-fungal agent case report aspergillus oryzae fungal endophthalmitis penetrating keratoplasty complications voriconazole |
| title | Non-Pathogenic Aspergillus oryzae Acute Exogenous Endophthalmitis after Penetrating Keratoplasty: The First Case Report in the Literature |
| title_full | Non-Pathogenic Aspergillus oryzae Acute Exogenous Endophthalmitis after Penetrating Keratoplasty: The First Case Report in the Literature |
| title_fullStr | Non-Pathogenic Aspergillus oryzae Acute Exogenous Endophthalmitis after Penetrating Keratoplasty: The First Case Report in the Literature |
| title_full_unstemmed | Non-Pathogenic Aspergillus oryzae Acute Exogenous Endophthalmitis after Penetrating Keratoplasty: The First Case Report in the Literature |
| title_short | Non-Pathogenic Aspergillus oryzae Acute Exogenous Endophthalmitis after Penetrating Keratoplasty: The First Case Report in the Literature |
| title_sort | non pathogenic aspergillus oryzae acute exogenous endophthalmitis after penetrating keratoplasty the first case report in the literature |
| topic | anti-fungal agent case report aspergillus oryzae fungal endophthalmitis penetrating keratoplasty complications voriconazole |
| url | https://beta.karger.com/Article/FullText/531801 |
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