Body Mass Index, Interleukin-6 Signaling and Multiple Sclerosis: A Mendelian Randomization Study

Body Mass Index, Interleukin-6 Signaling and Multiple Sclerosis: A Mendelian Randomization Study

ObjectivesWe explored whether genetically predicted increased body mass index (BMI) modulates multiple sclerosis (MS) risk through interleukin-6 (IL-6) signaling.MethodsWe performed a two-sample Mendelian randomization (MR) study using multiple genome-wide association studies (GWAS) datasets for BMI...

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Bibliographic Details
Main Authors: Marijne Vandebergh, Sara Becelaere, CHARGE Inflammation Working Group, Bénédicte Dubois, An Goris
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
Mendelian randomization
multiple sclerosis
obesity
interleukin-6
c-reactive protein
genetic epidemiology
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.834644/full

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