Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study
Objective:This study aimed to describe and compare the nutritional status of adult patients submitted to allogeneic hematopoietic stem cell transplantation at two different time points (admission and discharge).Methods:A retrospective, descriptive and quantitative study was performed based on clinic...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-12-01
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| Series: | Revista Brasileira de Hematologia e Hemoterapia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000600414&lng=en&tlng=en |
| _version_ | 1818008812390449152 |
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| author | Érika Elias Ferreira Daiane Cristina Guerra Kátia Baluz Wander de Resende Furtado Luis Fernando da Silva Bouzas |
| author_facet | Érika Elias Ferreira Daiane Cristina Guerra Kátia Baluz Wander de Resende Furtado Luis Fernando da Silva Bouzas |
| author_sort | Érika Elias Ferreira |
| collection | DOAJ |
| description | Objective:This study aimed to describe and compare the nutritional status of adult patients submitted to allogeneic hematopoietic stem cell transplantation at two different time points (admission and discharge).Methods:A retrospective, descriptive and quantitative study was performed based on clinical, laboratory and nutritional data obtained from medical records of adult patients of both genders submitted to allogeneic hematopoietic stem cell transplantation in a bone marrow transplantation reference center in Rio de Janeiro in the period from 2010 to 2013. Statistical analysis was performed using the SPSS software (version 22.0).Results:Sixty-four patients were evaluated. The mean age was 42.1 ± 3.2 years and the most prevalent disease was acute myeloid leukemia (39%). There was a high prevalence of gastrointestinal symptoms including nausea (100%), vomiting (97%) and mucositis (93%). Between admission and discharge there was a significant decrease in the median weight (−2.5 kg; 71.5 vs. 68.75 kg; p-value < 0.001), body mass index (−0.9kg/m2; 24.8 vs. 24.4kg/m2; p-value < 0.001), and serum albumin levels (−0.2g/dL; 3.7 vs. 3.6g/dL; p-value = 0.024). The survival time after hematopoietic stem cell transplantation correlated negatively with C-reactive protein at discharge (CC = −0.72; p-value < 0.001) and positively with serum albumin levels (CC = 0.56; p-value = 0.004) and with high total protein level at discharge (CC = 0.53; p-value = 0.006).Conclusion:Our results suggest that patients submitted to allogeneic hematopoietic stem cell transplantation have compromised nutritional status during the hospital stay for transplantation. |
| first_indexed | 2024-04-14T05:33:55Z |
| format | Article |
| id | doaj.art-8d53924ebe02488fb22cfa21359437c0 |
| institution | Directory Open Access Journal |
| issn | 1806-0870 |
| language | English |
| last_indexed | 2024-04-14T05:33:55Z |
| publishDate | 2014-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Revista Brasileira de Hematologia e Hemoterapia |
| spelling | doaj.art-8d53924ebe02488fb22cfa21359437c02022-12-22T02:09:43ZengElsevierRevista Brasileira de Hematologia e Hemoterapia1806-08702014-12-0136641441910.1016/j.bjhh.2014.07.014S1516-84842014000600414Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective studyÉrika Elias FerreiraDaiane Cristina GuerraKátia BaluzWander de Resende FurtadoLuis Fernando da Silva BouzasObjective:This study aimed to describe and compare the nutritional status of adult patients submitted to allogeneic hematopoietic stem cell transplantation at two different time points (admission and discharge).Methods:A retrospective, descriptive and quantitative study was performed based on clinical, laboratory and nutritional data obtained from medical records of adult patients of both genders submitted to allogeneic hematopoietic stem cell transplantation in a bone marrow transplantation reference center in Rio de Janeiro in the period from 2010 to 2013. Statistical analysis was performed using the SPSS software (version 22.0).Results:Sixty-four patients were evaluated. The mean age was 42.1 ± 3.2 years and the most prevalent disease was acute myeloid leukemia (39%). There was a high prevalence of gastrointestinal symptoms including nausea (100%), vomiting (97%) and mucositis (93%). Between admission and discharge there was a significant decrease in the median weight (−2.5 kg; 71.5 vs. 68.75 kg; p-value < 0.001), body mass index (−0.9kg/m2; 24.8 vs. 24.4kg/m2; p-value < 0.001), and serum albumin levels (−0.2g/dL; 3.7 vs. 3.6g/dL; p-value = 0.024). The survival time after hematopoietic stem cell transplantation correlated negatively with C-reactive protein at discharge (CC = −0.72; p-value < 0.001) and positively with serum albumin levels (CC = 0.56; p-value = 0.004) and with high total protein level at discharge (CC = 0.53; p-value = 0.006).Conclusion:Our results suggest that patients submitted to allogeneic hematopoietic stem cell transplantation have compromised nutritional status during the hospital stay for transplantation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000600414&lng=en&tlng=enHematopoietic stem celltransplantationNutritional statusNutritional therapy |
| spellingShingle | Érika Elias Ferreira Daiane Cristina Guerra Kátia Baluz Wander de Resende Furtado Luis Fernando da Silva Bouzas Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study Revista Brasileira de Hematologia e Hemoterapia Hematopoietic stem cell transplantation Nutritional status Nutritional therapy |
| title | Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study |
| title_full | Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study |
| title_fullStr | Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study |
| title_full_unstemmed | Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study |
| title_short | Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study |
| title_sort | nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells a retrospective study |
| topic | Hematopoietic stem cell transplantation Nutritional status Nutritional therapy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000600414&lng=en&tlng=en |
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